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Human TSH receptor Protein expressed in Wheat germ - ABIN1330596
Nagata, Nakayama, Higaki, Ochi, Kanai, Matsushita, Kuwamoto, Kato, Murakami, Iwasaki, Nanba, Kimura, Hayashi: Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBV-infected B lymphocytes with TRAbs on their surface. in Autoimmunity 2015
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Functional thyroid differentiation in zebrafish was examined and the role of TSHR signaling during thyroid organogenesis, was characterized.
Among the evaluated TSHR gene SNPs, the rs4411444 GG genotype and the rs4903961 C allele in the enhancer regions of the TSHR gene were most strongly associated with the development of Graves disease, especially intractable disease, and that of Hashimoto disease, respectively.
Low expression of TSHR is associated with dilated cardiomyopathy and impaired left ventricular function accompanied by increased risk of death.
Data suggest iodination of TG is involved in regulation of NIS expression in thyroid follicle via TSH/TSHR signaling; NIS expression and PKA activity are up-regulated by lowly iodinated TG; NIS expression is down-regulated and PKC (zeige PRRT2 Proteine) activity up-regulated by highly iodinated TG. (TG, thyroglobulin (zeige TG Proteine); NIS, sodium/iodide symporter; PK, protein kinase (zeige CDK7 Proteine); TSH, thyroid-stimulating hormone; TSHR, thyroid-stimulating hormone receptor)
Monoallelic TSHR mutations are significantly associated with positive newborn screen for congenital hypothyroidism, and the association is further strengthened by the coexistence of monoallelic DUOX2 (zeige DUOX2 Proteine) mutations.
findings proved that iodinated TG in thyroid follicular lumen regulated TTF-1 and PAX8 expression through thyroid stimulating hormone/thyroid stimulating hormone receptor (TSH/TSHR) mediated cAMP-PKA and PLC-PKC signaling pathways.
The role of TSH Receptor cleavage into subunits and shedding of the A-Subunit in Graves' disease pathogenesis is reviewed.
Data (including data from studies using knockout mice) suggest that thyrotropin/thyrotropin receptor signal transduction stimulates thyroglobulin (zeige TG Proteine) phosphorylation and contributes to enhanced de novo triiodothyronine formation in thyrocytes.
a hot-spot mutation in EZH1 (zeige EZH1 Proteine) is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 (zeige EZH1 Proteine) and TSHR mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 (zeige EZH1 Proteine) mutations cooperate to induce the hyperproliferation of thyroid cells
Germline mutation in the thyrotropin receptor gene is associated with non-autoimmune hyperthyroidism.
Congenital Hypothyroidism With Gland-in-Situ 59% attributable to mutations in TSHR.
Data indicate that splenic T cells from thyroid stimulating hormone receptor (TSHR) A-subunit primed animals undergoing Graves' orbitopathy (GO) showed proliferative responses to purified TSHR antigen and secreted proinflammatory cytokines.
Lung fibroblasts of TSHR KO mice have decreased cell surface Igf1r (zeige IGF1R Proteine) expression, and have Igf1r (zeige IGF1R Proteine) protein and protein fragments in both cytoplasm and nucleus. Igf1r (zeige IGF1R Proteine) mRNA levels were similar between TSHR KO and WT mice.
The mechanism, underlying TSH-induced liver triglyceride accumulation, involved that TSH, through its receptor TSHR, triggered hepatic SREBP-1c (zeige SREBF1 Proteine) activity.
These findings suggest that activation of TSHR directly inhibits FASN (zeige FASN Proteine) expression in mature adipocytes, possibly mediated by PKA and ERK (zeige EPHB2 Proteine)
A novel role for TSHR in behavioral and neurological phenotypes of Attention deficit/hyperactivity disorder.
The data indicate functional TSHR is expressed in ventricular myocytes and mediates TSH-induced BNP secretion and HMGCR (zeige HMGCR Proteine) up-regulation through the cAMP/PKA/pCREB signaling pathway.
findings demonstrate TSH-R expression is thymus-specific within the immune system; data support the notion of a novel neuroendocrine-immune interaction in which TSH-R signaling in the thymus, most likely mediated by TSH, enhances thymic T-cell development
The inhibition of hepatic PEPCK (zeige PEPCK Proteine) and G6P and enhanced expression of GK contributed to the development of fasting hypoglycemia in Tshr-ko mice.
UCP-1 (zeige UCP1 Proteine) and TSHR co-localized in retrobulbar adipose tissues in murine models of Graves' disease.
Cloned a thyroid-stimulating hormone receptor (TSHR) cDNA from thyroid glands. The sequence of this cDNA indicated that it encoded a 739 amino acid TSHR splice variant that lacked exon 5 (TSHR739).
Localization of thyrotropin receptor and thyroglobulin (zeige TG Proteine) in the bovine corpus luteum.
analysis of activation switch in the thyrotropin receptor
Rhes (zeige RASD2 Proteine) can interfere with the functional activity of wt and mutated TSHr.
Increased receptor binding by bovine (b) TSH bound to monoclonal antibody to bTSHbeta-subunit.
the hinge region represents an extracellular intermediate connector for both hormone binding and signal transduction of the thyroid stimulating hormone receptor
The equine TSHR is not responsive to equine chorionic gonadotropin but is more sensitive to human CG than the human TSHR
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
, thyroid-stimulating hormone receptor
, thyrotropin receptor
, seven transmembrane helix receptor
, thyrotropin receptor-I, hTSHR-I