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anti-Human Thyroglobulin Antikörper:
anti-Mouse (Murine) Thyroglobulin Antikörper:
anti-Rat (Rattus) Thyroglobulin Antikörper:
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Human Monoclonal Thyroglobulin Primary Antibody für IHC (fro), IHC (p) - ABIN967179
Ossendorp, Bruning, Van den Brink, De Boer: Efficient selection of high-affinity B cell hybridomas using antigen-coated magnetic beads. in Journal of immunological methods 1989
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Human Monoclonal Thyroglobulin Primary Antibody für IHC (p) - ABIN94483
Magro, Perissinotto, Schiappacassi, Goletz, Otto, Müller, Bisceglia, Brown, Ellis, Grasso, Colombatti, Perris: Proteomic and postproteomic characterization of keratan sulfate-glycanated isoforms of thyroglobulin and transferrin uniquely elaborated by papillary thyroid carcinomas. in The American journal of pathology 2003
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Tg appears to be a novel protein elaborated as a single event at the base of vertebrates and virtually unchanged thereafter.
Study shows that TH is downregulated in papillary thyroid carcinoma.
The purpose of the present study was to identify and characterize new mutations in the TG gene.
this study shows that monogenic Hashimoto thyroiditis is associated with a variant in the thyroglobulin gene
A novel rare missense mutation in the TG gene was identified. The ChEL domain is critical for protein folding and patients with congenital hypothyroidism due to misfolded TG may present without low serum TG despite the TG gene mutations.
High thyroglobulin expression is associated with mediastinal lymph node and lung metastases in thyroid cancer.
Thyroglobulin determination in fine needle aspiration biopsy washout of suspicious lymph nodes can be used in the diagnosis of recurrent papillary thyroid carcinoma.
Positive preoperative serum TgAb is associated with worse primary tumour characteristics but rarely showed poor prognosis, probably due to more aggressive treatment of these subjects.
Single nucleotide polymorphisms in the TG gene were associated with the development of Hashimoto's disease and Graves' disease, the intractability of Graves' disease, and the levels of TG mRNA expression, serum TG, and serum anti-thyroglobulin antibody.
Data suggest iodination of TG is involved in regulation of NIS expression in thyroid follicle via TSH/TSHR signaling; NIS expression and PKA activity are up-regulated by lowly iodinated TG; NIS expression is down-regulated and PKC activity up-regulated by highly iodinated TG. (TG, thyroglobulin; NIS, sodium/iodide symporter; PK, protein kinase; TSH, thyroid-stimulating hormone; TSHR, thyroid-stimulating hormone receptor)
Data show that the cutoff value for thyroglobulin measurement with fine-needle aspiration (Tg-FNA) was higher in patients with thyroids than in patients without thyroids.
findings proved that iodinated TG in thyroid follicular lumen regulated TTF-1 and PAX8 expression through thyroid stimulating hormone/thyroid stimulating hormone receptor (TSH/TSHR) mediated cAMP-PKA and PLC-PKC signaling pathways.
Data (including data from studies using knockout mice) suggest that thyrotropin/thyrotropin receptor signal transduction stimulates thyroglobulin phosphorylation and contributes to enhanced de novo triiodothyronine formation in thyrocytes.
Multiple factors should be taken into consideration when evaluating Tg as a marker of ID in adult populations, and the Tg results may depend on the assay used. Still, Tg is a sensitive marker of ID
Biallelic TG mutations most commonly underlie severe congenital hypothyroidism.
Mutations in Thyroglobulin gene is associated with metastasis in Thyroid Cancer.
Mutations in the genes for thyroglobulin and thyroid peroxidase cause thyroid dyshormonogenesis and autosomal-recessive intellectual disability
Patients with low-and intermediate-risk differentiated thyroid carcinoma could be considered cured when their serum thyroglobulin levels were changed 6-12 months after thyroid ablation.
The system is characterized by a very high sensitivity and specificity allowing the ex-vivo detection of sub ng/ml concentrations of human Thyroglobulin from needle washouts of fine-needle aspiration biopsies of thyroid nodule from different patients.
22 rare non-polymorphic variants including six truncating variants and 16 missense variants of unknown significance in Chinese patients with congenital hypothyroidism.
Data suggest that primary functions of TG include iodide storage and thyroid hormonogenesis; combinations of nonsense mutations, frameshift mutations, splice site mutations, and missense mutations in TG occur spontaneously to cause congenital hypothyroidism and thyroidal endoplasmic reticulum stress. [REVIEW]
antepenultimate residue of TG as a major T3-forming site, but also demonstrate that the side chain of this residue intimately interacts with the same residue in the apposed monomer of the TG dimer.
Findings suggest that coumestrol treatment may have some beneficial actions against thyroid-specific thyroglobulin (Tg) autoantibody production in the development of autoimmune thyroiditis through suppression of Th1 response.
these data identify for the first time a Tg T cell epitope as a spontaneous target in ISAT.
Final acquisition of secretory competence includes conformational maturation in the interval between linker and hinge segments of region I of thyroglobulin.
The results showed that thyroglobulin message or protein is not expressed in placenta, decidua, or ovary in any stages of pregnancy.
Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO.
These results indicate that Runx2 deficiency in mice causes decreased Tg expression and a novel type of hypothyroidism.
Development of iodine-accelerated autoimmune thyroiditis in NOD.H2h4 mice is not associated with enhanced iodine organification or differential B- or T-cell responses to iodinated determinants in Tg.
specific properties of distinct Tg ChEL mutants may result in distinct patterns of Tg monomer folding
Five novel autoimmune thyroiditis-causing T cell epitopes of thyroglobulin (Tgn) have been delineated and mapped with an algorithm that predicts Tgn immunopathogenic peptides containing I-A(k)-binding motifs.
iodotyrosyl formation in normal thyroglobulin confers pathogenic potential to certain peptides that may otherwise remain innocuous and undetectable by conventional mapping methods
Tg could initiate glomerular injury by reproducing the actions of TGF-beta1 in the mesangial cell.
Data indicate that the R19K mutation induces local misfolding in the amino-terminal domain of Tg that has global effects on Tg transport and thyroid hormonogenesis.
Together these results suggest that a unique low molecular weight variant of Tg is expressed in the kidney, where it could serve both physiological and pathological roles, including that of an autoantigen.
Data suggest that flotillin-1 and flotillin-2 function as thyroglobulin-binding proteins in lipid rafts of thyrocytes; these interactions appear to exert negative-feedback effects on gene expression in thyrocytes.
There were no associations between x genotype and fertility related traits in this study.
The results of this study suggest that TG gene-specific SNPs may be a useful marker for growth traits in marker-assisted selection programs in beef cattle.
Solution studies, size exclusion chromatography, dynamic light scattering and analytical ultracentrifugation, demonstrated the size changes of thyroglobulin oligomers after nitric oxide treatment.
The genetic effects of thyroglobulin and casein alpha s1 alpha in the body fat distribution of cattle are reported.
TG gene-specific single nucleotide polymorphism may be a useful marker for meat quality traits.
The results confirm the lack of an association found by many other studies and suggest that these SNPs are not influential on the divergent intramuscular fat levels in the crossbred population tested.
Localization of thyrotropin receptor and thyroglobulin in the bovine corpus luteum.
Atrial natriuretic peptide inhibits iodide uptake and thyroglobulin messenger ribonucleic acid expression in cultured bovine thyroid follicles.
Markers at the thyroglobulin gene may be a useful predictor of marbling performance for producers raising Wagyu-based cattle; the SNP reported in the thyroglobulin gene was associated with marbling score in cattle with Wagyu inheritance
Single nucleotide polymorphism of thyroglobulin gene is associated with fat deposition.
we have demonstrated for the first time that thyroglobulin possesses proliferative effect on thyroid epithelial cells in addition to being the precursor of the thyroid hormones.
Immunization with Tg induces Graves'-like disease in mice and that our methods will provide a new animal model of Graves' disease.
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
, congenital goiter
, hereditary goitre