GPX3 Proteine (GPX3)

Mouse (Murine) Glutathione Peroxidase 3 (Plasma) (GPX3) Interaktionspartner

1. the antioxidant enzyme GPX3 localizes to lung extracellular matrix and is variably upregulated in interstitial lung diseases.

2. These results suggest that GPx3 is an important factor for inhibition of Acetaminopheninduced hepatotoxicity both in vivo and in vitro.

3. GPX3 promoter methylation predicts colorectal carcinoma sensitivity to platinum.

4. Results indicate that selenoprotein P (Sepp1) is important for this transport in selenium-replete mice but that glutathione peroxidase-3 (Gpx3) is not.

5. GPx3 may have a possible role in modulating prostate carcinogenesis.

6. Sepp1(UF) and small selenium-containing proteins are filtered by the glomerulus and taken up by PCT cells via megalin-mediated endocytosis, preventing loss of selenium in the urine and providing selenium for the synthesis of glutathione peroxidase-3

7. GPX3 may play a major role in reducing hydrogen peroxide during decidualization.

8. Data indicate that uptake of Sepp1 and Gpx3 by d-13 visceral yolk sac was independent of apoER2 and megalin.

9. an immunomodulatory role for GPX3 that limits the development of colitis-associated carcinoma.

10. We applied X-ray fluorescence microscopy to image selenium in mammalian tissues and identified a highly localized pool of this trace element at the basement membrane of kidneys that was associated with GPx3

11. These results show that glutathione peroxidase 3 from the blood binds to basement membranes of specific epithelial cells and indicate that the cells modify their basement membranes to cause the binding.

12. GPx-3 deficiency results in a prothrombotic state and vascular dysfunction that promotes platelet-dependent arterial thrombosis

13. Gpx3 and ERalpha gene expression are sensitive to circulating estrogens in skeletal muscle

14. Inflammatory injury in the intestine elicits an increase in E-GPx in the plasma that is associated with an increase in E-GPx mRNA in the kidney. This implies that renal production of E-GPx may be sensitive to insults distal to the kidney.

15. The increases in mRNA levels for CatS and GPX3 found in the aging C57BL/6 RPE/choroid appear to represent an increase in both the numbers of cells expressing these messages and an increase in the level of expression in individual cells.

16. The expression of Gpx3 decreased at the aortic sinus in a murine model of high-fat diet-induced atherogenesis.

17. GPX-3 may play a significant role in protecting cardiomyocytes from oxidative stress caused by hyperglycemia

18. This is the first report that a particular isotype of the glutathione peroxidase family is regulated by TCDD at both mRNA and protein levels

19. c-maf may be transcriptional regulator of GPx3 expression and modulate the antioxidative pathway in the kidney

20. estrogen has large effects on gene expression in white adipose tissue and GPX3 and CIDEA could be important mediators of the effects of estrogen on fat mass

Human Glutathione Peroxidase 3 (Plasma) (GPX3) Interaktionspartner

1. GPX3 rs736775 TC/CC were associated with intestinal type of gastric adenocarcinoma and was associated with improved Overall survival.

2. the antioxidant enzyme GPX3 localizes to lung extracellular matrix and is variably upregulated in interstitial lung diseases.

3. GPX1, GPX3 and GPX4 may be upregulated in response to a change in oxidative stress during an acute coronary syndromes

4. An association of the GPX3-TNIP1 locus with ALS is identified using cross-ethnic meta-analyses. [Meta-Analysis]

5. Study provides evidence that GPX3 methylation in bone marrow is associated with adverse prognosis and leukemia transformation in myelodysplastic syndrome.

6. this paper shows that GPx3 expression can be regulated independently via epigenetic or glucocorticoid receptor-mediated mechanisms in lung cancer cells

7. negative expression of GPX3 was related to poor prognosis in melanoma patients. These results suggest that methylation-mediated GPX3 repression may have critical implications for melanoma pathogenesis

8. The detection of the demethylated allele could be time and phe concentration dependent. The demethylated allele is suggested as an early epigenetic marker for an extracellular monitoring of an increased ROS production in newborns with PKU.

9. GPX1*Pro198Leu AND GPX3 rs2070593 as genetic risk markers for Italian asthmatic patients

10. A three-way interaction among maternal and fetal variants in BHMT2, GSTP1 and GPX3 contribute to congenital heart defects

11. GPX3 hypermethylation is frequent in chronic myeloid leukemia and is negatively associated with its expression.

12. Reduced GPX3 expression is associated with favorable/intermediate karyotypes but not with survival in de novo acute myeloid leukemia patients.

13. GPX1, GPX3, and GPX4 genes may play a role in clear cell renal cell carcinoma cancerogenesis.

14. GPX3 is frequently methylated in human papillary thyroid cancer and the expression of GPX3 was regulated by promoter region methylation

15. Our results suggest that promoter methylation may be a mechanism for inactivation of GPX3, possibly leading to subsequent carcinogenesis and progression of HCC

16. The T allele of -861A/T in GPX3 gene is a risk allele for the ischemic stroke phenotype.

17. GPx3 is a tumor suppressor gene in HCC.

18. Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants.

19. GPx3 may have a possible role in modulating prostate carcinogenesis.

20. Our results indicate that promoter methylation is one of the major causes of GPX3 downregulation in cervical cancer and GPX3 could serve as a predictive biomarker for lymph node metastasis and prognosis of cervical cancer.

Cow (Bovine) Glutathione Peroxidase 3 (Plasma) (GPX3) Interaktionspartner

1. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2, and decreased the expression of SOD2, GPX3, DAB2, and NR3C1. TNF and IL6 levels were also decreased while those of NAMPT were unaffected.