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Studied the importance of selenium in bovine female reproductive function. Gene expression analysis revealed selenoprotein gene GPX1 was significantly up-regulated in large healthy follicles.
did not find any significant inhibition of bovine GPx-1 by (S)- or (R)-misonidazole.
Data indicate mRNA level and activity of GPx1 are regulated by level of selenium supplied to hepatocytes.
homocysteine decreases GPx1 activity by altering the translational mechanism
glutathione peroxidase-1 activity is decreased by aminoglycosides through interference with selenocysteine incorporation
GPx1 plays a key role in blocking the promotion of porcine circovirus type 2 replication
The developmental expression of GPX1 and thioredoxin reductase during fetal development and the effect of maternal selenium consumption on the expression of these proteins are reported.
Notably, CUEDC2 (zeige CUEDC2 Proteine) promoted E3 ubiquitin ligases tripartite motif-containing 33 (TRIM33 (zeige TRIM33 Proteine))-mediated the antioxidant enzyme, glutathione peroxidase 1 (GPX1) ubiquitination, and proteasome-dependent degradation.
GPx1 does not clearly exacerbate hyperoxia-induced increases in oxidative stress or lung injury but may alter pulmonary immune function.
GPx-1 expression deters the unfolded protein response following exposure to cigarette smoke
Glutathione peroxidase 1 (GPx1) knockdown not only induced oxidative stress characterized by the increased production of reactive oxygen species (ROS (zeige ROS1 Proteine)) but also caused reductive stress indicated by an elevation of glutathione (GSH)/oxidized GSH (GSSG) ratio.
Exposure to far infrared rays significantly protects acute restraint stress oxidative burdens via inhibition of JAK2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine) signaling by induction of GPx-1.
Genetic inhibition of Gpx1 potentiates cocaine-induced renal damage via activation of AT1R (zeige AGTRAP Proteine) by inhibition of PI3K-Akt (zeige AKT1 Proteine) signaling.
Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced liver injury by induction of T-cell hyporesponsiveness through chronic reactive oxygen species exposure.
GPx1 was found to play a critical role in regulating pro-inflammatory pathways in vascular endothelium.
Plasmalogen enrichment via batyl alcohol supplementation attenuated atherosclerosis in ApoE (zeige APOE Proteine)- and ApoE (zeige APOE Proteine)/GPx1-deficient mice.
Gpx1 expression in the mouse skeletal muscle can be altered by both exercise and dyslipidemia through changes in DNA methylation (zeige HELLS Proteine), leading to a fine regulation of free radical metabolism.
GPX1, GPX3 and GPX4 may be upregulated in response to a change in oxidative stress during an acute coronary syndromes
The Pro198Leu polymorphism (rs1050450) to the selenoprotein glutathione peroxidase 1 gene (GPX1), and GSTM1 (zeige GSTM1 Proteine) deletion had no effect on mercury levels in mildly exposed people, suggesting these genetic variants impact mercury levels only in highly exposed populations.
Evaluation of Glutathione Peroxidase and KCNJ11 (zeige KCNJ11 Proteine) Gene Polymorphisms in Patients with New Onset Diabetes Mellitus After Renal Transplantation
G/C (rs8179169; Arg5Pro) and T/C (rs4991448; Leu6Pro) polymorphisms significantly associated with vitiligo (zeige MITF Proteine)
Data show that the inflammation of the gallbladder wall (IGW) correlated significantly with plasma GPX1 and hs-CRP (zeige CRP Proteine) (high-sensitivity C-reactive protein (zeige CRP Proteine)) values suggesting that inflammation and oxidative stress are related.
High GPX1 expression is associated with oral squamous cell carcinoma.
GPX1 is a gatekeeper restraining the oncogenic power of mitochondrial ROS (zeige ROS1 Proteine) generated by SOD2 (zeige SOD2 Proteine) is presented. Review.
Using lens epithelial cells derived from targeted inactivation of Prdx6 (zeige PRDX6 Proteine)(-/-) gene and relative enzymatic and stability assays, we discovered dramatic increases in GSH-peroxidase (30%) and aiPLA2 (zeige PRDX6 Proteine) (37%) activities and stability in the K122/142 R mutant, suggesting Sumo1 (zeige SUMO1 Proteine) destabilized Prdx6 (zeige PRDX6 Proteine) integrity
Coronary angiography findings indicated that individuals possessing Pro198Leu (CT) polymorphism were found to be associated with low erythrocyte GPX-1 activity and increased susceptibility for coronary artery disease.
High GPX1 expression is associated with Thyroid Tumors.
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
glutathione peroxidase Gpx1
, glutathione peroxidase
, cellular glutathione peroxidase
, cytosolic glutathione peroxidase
, putative glutathione peroxidase
, selenium-dependent glutathione peroxidase 1
, glutathione peroxidase 1
, glutathione peroxidase 1 S homeolog