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Identification of novel prostate cancer drivers, ERF, CREB3L1, and POU2F2, using RegNetDriver, a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network.
These findings indicate that the miR (zeige MLXIP Proteine)-146a-CREB3L1-FGFBP1 (zeige FGFBP1 Proteine) signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells.
Ceramide inverts the membrane orientation of TMS4SF20, creating a form of TM4SF20 that stimulates the cleavage of CREB3L1.
The results suggest that CREB3L1 is required for decidualization in mice and humans and may be linked to the pathogenesis of endometriosis in a progesterone-dependent manner.
Our data further strengthens the role for CREB3L1 as a metastasis suppressor in breast cancer and demonstrates that epigenetic silencing is a major regulator of the loss of CREB3L1 expression
CREB3L1 was expressed in 19% of RCC, which is generally resistant to doxorubicin, but in 70% of diffuse (zeige XRCC1 Proteine) large B-cell lymphoma that is sensitive to doxorubicin.
CREB3L1 mRNA expression is downregulated in human bladder cancer.CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro.
Cleavage of CREB3L1 releases its NH2-terminal domain from membranes, allowing it to enter the nucleus where it binds to Smad4 (zeige SMAD4 Proteine) to activate transcription of genes encoding proteins required for assembly of collagen-containing extracellular matrix.
CREB3L1 expression may be a useful biomarker in identifying cancer cells sensitive to doxorubicin.
Case Reports: genetically confirmed primary renal sclerosing epithelioid fibrosarcoma with EWSR1 (zeige EWSR1 Proteine)-CREB3L1 gene fusion.
OASIS affects the expression of HIF-1alpha (zeige HIF1A Proteine) target genes through the protein interaction with HIF-1alpha (zeige HIF1A Proteine), and that OASIS-HIF-1alpha (zeige HIF1A Proteine) complexes may play essential roles in angiogenesis during bone development.
Higher levels of CREB3L1 protein are correlated with increased doxorubicin sensitivity of xenograft RCC (zeige XRCC1 Proteine) tumors
Increased susceptibility to dextran sulfate sodium-induced colitis in the endoplasmic reticulum stress transducer OASIS deficient mice.
We conclude that OASIS functions as an anti-regenerative transcription factor by establishing a non-permissive microenvironment to regenerating axons
Fbxw7 (zeige FBXW7 Proteine) controls osteogenesis and chondrogenesis by targeting OASIS and BBF2H7 (zeige CREB3L2 Proteine), respectively, for degradation.
Gliosis-specific transcription factor OASIS coincides with proteoglycan core protein (zeige EPYC Proteine) genes in the glial scar and inhibits neurite outgrowth.
Findings demonstrate a novel mechanism by which OASIS and its associated family members are modulated by the unfolded protein response to finely control astrocyte differentiation.
OASIS plays crucial roles in promoting the differentiation of early goblet cells to mature goblet cells in the large intestine.
OASIS may play a role in bone formation through the expression of type I collagen and the secretion of bone matrix proteins in fracture healing.
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system. May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity).
cAMP responsive element binding protein 3-like 1
, cyclic AMP-responsive element-binding protein 3-like protein 1-like
, BBF-2 homolog
, cAMP-responsive element-binding protein 3-like protein 1
, cyclic AMP-responsive element-binding protein 3-like protein 1
, old astrocyte specifically-induced substance
, old astrocyte specifically induced substance