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PGD2 signaling through the D-prostanoid receptor 1 (DP1) receptor is necessary for optimal microglia/macrophage activation and IFN expression after infection with a neurotropic coronavirus
Polymorphisms of prostaglandin D receptor (PTGDR) gene influence basal promoter activity and gene expression, as well as the cytokine secretory pattern.
An association was found between single nucleotide polymorphisms of the PTGFR and SLCO2A1 genes and the response to latanoprost in Han Chinese patients with glaucoma. These SNPs may be important determinants of differential response to latanoprost.
EP2 receptors seem to be able to distinguish endogenous ligands PGD2, PGE2 or prostaglandin F2alpha better than DP receptors.
PGD2 markedly augments disease activity through its ability to enhance the proinflammatory actions of macrophages and subsequent neutrophil activation.
Non-obligatory role of prostaglandin D2 receptor subtype 1 in rosacea: laropiprant in comparison to a placebo did not alleviate the symptoms of erythematoelangiectaic rosacea
EP2 receptors exhibit more constraints to mutations than DP receptors.
Low DP1 prostanoid receptor is associated with gastric cancer progression.
Lipocalin-type prostaglandin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the G protein-coupled receptor DP1 in an agonist-independent manner.
the PTGDR -549 C/T polymorphism confers susceptibility to asthma in Europeans and adults. However, no association was found between the PTGDR 441 C/T and -197 C/T polymorphisms or the CCC and TCT haplotypes and asthma susceptibility.
Genetic variant may play a role in NSAID induced acute urticaria.
PGD(2)-DP signaling reduces vascular permeability via endothelial cAMP/PKA/Tiam1/Rac1 pathway.
The PTGDR -441C/T polymorphism is not associated with asthma or its phenotypes in the North Indian population.
DP receptors amplify the biological response to CRTH2 activation and the CRTH2/DP heteromer might represent both a functional signaling unit for PGD(2) and a potential target for development of heteromer-directed therapy for allergic diseases
Genetic combinations described have functional implications in the PTGDR promoter activity by changing the transcription factors affinity that will help characterize different risk groups.
PGD(2) can induce MUC5B overproduction via ERK MAPK/RSK1/CREB signaling and that DP1 receptor may have suppressive effects in controlling MUC5B overproduction in the airway.
Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.
DP mediates eosinophils through the elevation of intracellular cAMP production but does not change CRTH2 expression; balance between DP and CRTH2 could influence the degree of PGD2-induced eosinophil migration
during allergen-elicited eosinophilic inflammatory reactions, cysteinyl-leukotriene production is regulated by DP1/DP2-orchestrated eosinophil activation
DP(1) receptors coupled to G(alphas) increase adenylate cyclase activity and cAMP/protein kinase A-dependent formation of lipid bodies, and DP(2) receptors coupled to G(alphai) increase calcium; each of these signals is required for LTC(4) production
A role for PGD2 signals acting through PTGDR in suppression of intestinal tumors.
Data indicate a PLA2G3-lipocalin-type PGD2 synthase (L-PGDS)-PGD2 receptor DP1 loop that drives mast cell maturation.
PGD(2)-DP signaling reduces vascular permeability both in vivo.
platelet DP1 is not present in mice. Despite this, DP1 deletion in mice augmented aneurysm formation and the hypertensive response to Ang II and accelerated atherogenesis and thrombogenesis.
The present study demonstrates that functional roles of PGD2 and its receptors appear to depend on the nature of the inflammation in chronic skin inflammation, chronic contact hypersensitivity and IgE-mediated chronic allergic skin inflammation
amino acid sequence alignment of human, mouse and rat DP receptors
After epicutaneous sensitization with ovalbumin (OVA), DP activation inhibits the migration of Langerhans cells (LC)s and affects the priming of antigen-specific T cells in the draining lymph nodes.
pain sensitivity was increased in prostaglandin D receptor mutant mice
The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.
, prostaglandin D2 receptor
, prostaglandin D receptor
, prostaglandin D2 receptor-like
, PGD receptor
, Prostanoid DP receptor
, prostaglandin D2 receptor (DP)
, prostanoid DP receptor