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High TERT Expression is associated with breast cancer.
TERT protein expression may be regulated by several mechanisms in addition to its promoter mutation.
Letter: TERT promoter mutation is a genetic cognate of urothelial papilloma, papillary urothelial neoplasm of low malignant potential and urothelial carcinoma, further supporting the hypothesis that TERT mutation is a frequent and early step in the transformation of many urothelial neoplasms.
Here it was found that there was no statistical difference between human TERT rs2736109 G>A, rs2735940 T>C, rs2853669 A>G, rs2736098 G>A, and rs2736100 T>G polymorphisms that can be associated with risk of Breast Cancer in a Turkish population.
the TERT promoter mutation may serve as a biomarker of prognostic stratification in patients with papillary urothelial neoplasm of low malignant potential
TERT promoter mutations are very rare in urachal adenocarcinomas (unlike in urothelial carcinoma).
Binary logistic regression analysis showed significant association of TERT rs2736100C with gallbladder carcinoma risk.
We found that THOR (zeige EIF4EBP1 Proteine) is hypermethylated in pancreatic tumor tissue when compared with normal tissue and that THOR (zeige EIF4EBP1 Proteine) methylation correlates with TERT expression in tumor samples. Our preliminary findings support the diagnostic and prognostic values of THOR (zeige EIF4EBP1 Proteine) in pancreatic cancer.
TERT structural rearrangements are associated with metastatic pheochromocytomas.
occurrence of TERT promoter mutations has a pivotal role in the disease progression as a secondary genetic event at a time when tumor cells face the need for telomere elongation to allow further proliferation.
The results establish that null mutation in trt-1 improves survival and attenuates damage to the DAergic system.
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase-deficient zebrafish show p53 (zeige TP53 Proteine)-dependent premature aging and reduced lifespan in the first generation.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomere shortening is more rapid in fas (zeige FASN Proteine) tert double mutants than in fas1 (zeige FAS Proteine), fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 (zeige POT1 Proteine) protein, POT1A (zeige POT1 Proteine) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (zeige DKC1 Proteine) associates with active telomerase RNP (zeige RNPC3 Proteine) particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
These preclinical data in mouse models and human cells provide a strong rationale for the development of pharmacological approaches to target BMI1 (zeige BMI1 Proteine)-mediated mitochondrial regulation and protection from DNA damage to sustain the regenerative potential of the skeletal muscle in conditions of chronic muscle wasting.
Reactivation of Tert in the hippocampus was sufficient to normalize the depressive but not the aggressive behaviors of Tert(-/-) mice. Conversely, re-expression of Tert in the medial prefrontal cortex (mPFC) reversed the aggressive but not the depressive behavior of Tert(-/-) mice.
Nrf2 (zeige NFE2L2 Proteine)-driven TERT regulates pentose phosphate pathway in glioblastoma.
TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 (zeige E2F1 Proteine) target gene expression in smooth muscle cells.
these findings support a model in which gain of TERT function modulates mTORC1 activity and induces autophagy.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (zeige MYC Proteine), Cyc (zeige CYCS Proteine)-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment
Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress
Wnt10a (zeige WNT10A Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
This study reports the characterisation of two novel mouse TERT splice variants, Ins (zeige INS Proteine)-i1[1-102] (Insi1 for short) and Del-e12 (zeige ELSPBP1 Proteine)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.
TERT may promote gastric cancer metastasis through the TERT-miR (zeige MLXIP Proteine)-29a-ITGB1 (zeige ITGB1 Proteine) regulatory pathway.
TERT serves an essential role in formation of the anterior-posterior axis in Xenopus laevis embryos; role for telomerase as a transcriptional modulator of the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signalling pathway
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
telomerase catalytic subunit
, telomerase-associated protein 2
, Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, telomerase reverse transcriptase beta
, Telomerase catalytic subunit