TET1 Produkte
(Tet Methylcytosine Dioxygenase 1 (TET1))
Kategorien
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.
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Ausgewählte TET1 Kategorien
TET1 Antikörper
High quality antibodies with extensive validation data.
TET1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TET1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (2)
Kat. Nr.
ABIN1327194
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (1)
Kat. Nr.
ABIN7159633
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB
Validierungen
- (1)
Kat. Nr.
ABIN6244141
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene TET1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1322493
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Baculovirus infected Insect Cells, Insect cells (Sf9)
Validierungen
Kat. Nr.
ABIN6700690
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TET1 Produkten
: "Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs." in: Stem cells international, Vol. 2018, pp. 6013728, (2018) (PubMed).: "TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing." in: The EMBO journal, Vol. 35, Issue 3, pp. 335-55, (2016) (PubMed).
: "Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate." in: The Journal of biological chemistry, Vol. 291, Issue 13, pp. 6754-71, (2016) (PubMed).
: "Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells." in: Oncology letters, Vol. 10, Issue 3, pp. 1287-1292, (2015) (PubMed).
: "Restored expression levels of TET1 decrease the proliferation and migration of renal carcinoma cells." in: Molecular medicine reports, Vol. 12, Issue 4, pp. 4837-42, (2015) (PubMed).
: "Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT)." in: The Journal of biological chemistry, Vol. 290, Issue 8, pp. 4801-12, (2015) (PubMed).
: "TET1-mediated different transcriptional regulation in prostate cancer." in: International journal of clinical and experimental medicine, Vol. 8, Issue 1, pp. 203-11, (2015) (PubMed).
Synonyme und alternative Namen zu TET1
tet methylcytosine dioxygenase 1 (TET1), tet methylcytosine dioxygenase 1 (Tet1), solute carrier family 25 member 16 (SLC25A16), 2510010B09Rik, AA517754, bA119F7.1, BB001228, CXXC6, Cxxc6, D10Ertd17e, LCX, mKIAA1676Bezeichner auf Proteinebene für TET1
- CXXC finger 6
- CXXC zinc finger 6
- CXXC-type zinc finger protein 6
- leukemia-associated protein with a CXXC domain
- methylcytosine dioxygenase TET1
- ten-eleven translocation 1 gene protein
- ten-eleven translocation-1
- tet oncogene 1
- ten-eleven translocation 1 gene protein homolog
- tet methylcytosine dioxygenase 1
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