TDG Produkte
(Thymine-DNA Glycosylase (TDG))
Kategorien
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008].
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Ausgewählte TDG Kategorien
TDG Antikörper
High quality antibodies with extensive validation data.
TDG ELISA Kits
Reliable ELISA kits for a wide range of species.
TDG Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TDG Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7153379
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, FACS
Validierungen
- (2)
Kat. Nr.
ABIN390559
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, FACS
Validierungen
- (2)
Kat. Nr.
ABIN390560
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene TDG ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959949
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1134027
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene TDG Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1322426
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1785499
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
- (1)
Kat. Nr.
ABIN3134519
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TDG Produkten
: "Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability." in: Genome biology, Vol. 19, Issue 1, pp. 37, (2018) (PubMed).: "A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity." in: Biosensors & bioelectronics, Vol. 86, pp. 849-57, (2016) (PubMed).
: "TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1." in: Oncogene, Vol. 36, Issue 16, pp. 2202-2214, (2016) (PubMed).
: "Base excision repair of tandem modifications in a methylated CpG dinucleotide." in: The Journal of biological chemistry, Vol. 289, Issue 20, pp. 13996-4008, (2014) (PubMed).
: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." in: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).
: "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover." in: The EMBO journal, Vol. 21, Issue 6, pp. 1456-64, (2002) (PubMed).
: "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12767-74, (1996) (PubMed).
: "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1642-6, (1994) (PubMed).
Synonyme und alternative Namen zu TDG
thymine DNA glycosylase (TDG), thymine DNA glycosylase, tandem duplicate 1 (tdg.1), putative g/t mismatch-specific thymine DNA glycosylase (Smp_149220), G/T mismatch-specific thymine DNA glycosylase (Tsp_05734), thymine DNA glycosylase S homeolog (tdg.S), thymine DNA glycosylase (tdg), thymine DNA glycosylase (Tdg), thymine-DNA glycosylase (Tdg), 5-MCDG, E130317C12Rik, hTDG, JZA-3, Jza1, MGC82456, MGC89441, wu:fb44b11, zgc:110622Bezeichner auf Proteinebene für TDG
- G/T mismatch-specific thymine DNA glycosylase
- G/T mismatch DNA glycosylase
- G/t mismatch-specific thymine DNA glycosylase
- thymine-DNA glycosylase
- G/T mismatch-specific thymine DNA glycosylase-like
- g/T mismatch-specific thymine DNA glycosylase-like
- C-JUN leucine zipper interactive protein JZA-3
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