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The results indicate that PKC (zeige FYN Proteine) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase by Ang II (zeige AGT Proteine).
Phorbol 12-myristate 13-acetate activation of ERK (zeige MAPK1 Proteine) and JNK (zeige MAPK8 Proteine) signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.
The Pro(168) residue in the C1a domain of full length PKCtheta; plays a critical role in the ligand and membrane binding, while exchanging the residue (Lys (zeige LYZ Proteine)(240)) at the same position in C1b domain of full length PKCtheta; only modestly reduced the membrane interaction.
PKC-theta; is strongly and exclusively expressed in GISTs and interacts with intracellular mutant KIT to promote its stabilization by increased retention in the Golgi complex. PKC-theta; plays critical roles in the sustained activation of MT-KITs. Overexpression of PKC-theta; significantly correlates with several clinicopathological parameters
PCR and transcriptome analysis suggest that the genes CD3D (zeige CD3D Proteine) and PKRCQ together can be used as a model for differentiating between B-cell and T-cell acute lymphoblastic leukemia.
PKC-theta; is a critical factor for type 2 innate lymphoid cells activation that contributes to TH2 cell differentiation, which is associated with IRF4 (zeige IRF4 Proteine) and NFAT1 (zeige NFAT1 Proteine) expression in allergic lung inflammation.
Enhanced PRKCQ/PKCtheta; expression can promote growth-factor-independent growth, anoikis resistance, and migration. PRKCQ critically regulates growth and survival of a subset of TNBC.
Data suggest that, in T-lymphocytes, nitric oxide generated by eNOS (zeige NOS3 Proteine) S-nitrosylates Cys374 on ACTB (zeige ACTB Proteine) and thus regulates activation/recruitment of PRKCQ at immune synapse; S-nitrosylation of beta-actin (zeige ACTB Proteine) impairs actin binding to PFN1 (zeige PFN1 Proteine) and regulates protein transport in lamellipodia. (eNOS (zeige NOS3 Proteine) = nitric oxide synthase 3; ACTB (zeige ACTB Proteine) = beta-actin (zeige ACTB Proteine); PRKCQ = protein kinase C-theta; PFN1 (zeige PFN1 Proteine) = profilin-1 (zeige PFN1 Proteine))
PKCtheta;-induced phosphorylations control the ability of Fra-1 (zeige FOSL1 Proteine) to stimulate gene expression and breast cancer cell migration.
Within the nucleus, PKC-theta; catalytic activity maintains the Ser536 phosphorylation on the p65 subunit of NF-kappaB (also known as RelA) and can directly influence chromatin accessibility at transcriptional memory genes by regulating H2B deposition.
Data show that tonantzitlolone (TZL) was able to induce protein kinase c theta (PKCtheta;)-dependent heat shock transcription factor 1 (HSF1 (zeige HSF1 Proteine))phosphorylation.
The PRKCQ polymorphism is not associated with Behcet's Disease.
PKCtheta; selectively inactivates the negative regulator of F-actin generation, Coronin 1A (zeige CORO1A Proteine), at the center of the T cell interface with the antigen presenting cell (APC (zeige APC Proteine)). This allows for effective generation of the large actin-based lamellum required for recruitment of the Notch (zeige NOTCH1 Proteine)-processing membrane metalloproteinase ADAM10 (zeige ADAM10 Proteine).
Results suggest that while PKCtheta; is involved in Treg cell differentiation in vivo, it is dispensable for Treg-mediated suppression.
Data show that pharmacological inhibition of Protein Kinase C theta (PKCtheta;) in Duchenne Muscular Dystrophy (DMD (zeige DMD Proteine)) can be considered an attractive strategy to modulate immune response and prevent the progression of the disease.
Sumoylation of PKC-theta; was essential for T cell activation. Desumoylation did not affect the catalytic activity of PKC-theta; but inhibited the association of CD28 (zeige CD28 Proteine) with PKC-theta; and filamin A (zeige FLNA Proteine) and impaired the assembly of a mature immunological synapse.
Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A (zeige CORO1A Proteine) on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB (zeige NFKB1 Proteine) transactivation.
Knockdown of PKCtheta suppresses phosphorylation of IKK (zeige CHUK Proteine) and JNK (zeige MAPK8 Proteine) and consequently attenuates the HOCl-impaired insulin (zeige INS Proteine) signaling pathway.
Data indicate that Protein kinase C theta; (PKCtheta;) is critical for stabilizing Th17 cell phenotype.
Data suggest that protein kinase (zeige CDK7 Proteine) Ctheta (PKCtheta;) inhibition alone is insufficient for complete efficacy in rodent arthritis model.
Inhibition of PKC-theta preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
protein kinase C theta type
, PKC theta