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anti-Human CD28 Antikörper:
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Mouse (Murine) Monoclonal CD28 Primary Antibody für BR, CyTox - ABIN1176978
Gelfanov, Lai, Gelfanova, Dong, Su, Liao: Differential requirement of CD28 costimulation for activation of murine CD8+ intestinal intraepithelial lymphocyte subsets and lymph node cells. in Journal of immunology (Baltimore, Md. : 1950) 1995
Show all 14 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody für FACS - ABIN2689149
Wells, Gudmundsdottir, Turka et al.: Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative ... in The Journal of clinical investigation 1998
Show all 13 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody für BR, CyTox - ABIN2689144
Bluestone: New perspectives of CD28-B7-mediated T cell costimulation. in Immunity 1995
Show all 13 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody für Func, FACS - ABIN370901
Gross, Callas, Allison: Identification and distribution of the costimulatory receptor CD28 in the mouse. in Journal of immunology (Baltimore, Md. : 1950) 1992
Show all 16 Pubmed References
Rat (Rattus) Monoclonal CD28 Primary Antibody für Func, FACS - ABIN2749055
Guillonneau, Séveno, Dugast, Li, Renaudin, Haspot, Usal, Veziers, Anegon, Vanhove: Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients. in Journal of immunology (Baltimore, Md. : 1950) 2007
Show all 9 Pubmed References
Rat (Rattus) Monoclonal CD28 Primary Antibody für Func, FACS - ABIN2749056
Kerstan, Armbruster, Leverkus, Hünig: Cyclosporin A abolishes CD28-mediated resistance to CD95-induced apoptosis via superinduction of caspase-3. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Rat (Rattus) Monoclonal CD28 Primary Antibody für Func, FACS - ABIN611634
van den Brandt, Wang, Reichardt: Resistance of single-positive thymocytes to glucocorticoid-induced apoptosis is mediated by CD28 signaling. in Molecular endocrinology (Baltimore, Md.) 2004
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Human Monoclonal CD28 Primary Antibody für FACS, Func - ABIN638435
Nunès, Klasen, Ragueneau, Pavon, Couez, Mawas, Bagnasco, Olive: CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events. in International immunology 1993
Show all 7 Pubmed References
Human Monoclonal CD28 Primary Antibody für FACS, Func - ABIN349710
Galea-Lauri, Darling, Gan, Krivochtchapov, Kuiper, Gäken, Souberbielle, Farzaneh: Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells. in Journal of immunology (Baltimore, Md. : 1950) 1999
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Human Monoclonal CD28 Primary Antibody für FACS, Func - ABIN349705
Jeong, Qiao, Nascimbeni, Hu, Rehermann, Murthy, Liang: Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates. in Journal of virology 2004
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Data suggest that a delicate balance between T-cell-specific surface glycoprotein CD28 (CD28) and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) biology plays a significant role in both Treg cell homeostasis and function.
Studied haplotypes of CD28 and cytotoxic T-lymphocyte associated protein 4 (CTLA4) and their association to primary Sjogren's syndrome susceptibility in a Mexican population.
Thereby, our findings demonstrated that CD28(+)CD8(-) and CD4(+)CD25(high) regulatory T cells might exert distinct effect on modulating antiviral immune responses.
The results of this study indicated that the CD28 rs3116496 polymorphism might impact the risk of schizophrenia, especially deficit schizophrenia.
CD28 may be a tumor suppressor gene and rs3116496 polymorphism of CD28 gene showed positively correlation with the increased risk of breast cancer.
percentage of CD4(+) CD28(null) T-cells was significantly higher in type 1 diabetes patients with and without microvascular complications compared with controls
Suggest that genetic polymorphisms of CD28 function as sex-dependent risk factors for development of acute rejection in an Iranian kidney transplant population.
the expression of CD28 was lower in both Sjogren's syndrome and systemic sclerosis patients
The fraction of CD4(+)CD28(null) cells proved to be predictive on outcome in congestive heart failure-patients presenting with atrial fibrillation.
In this study we systematically evaluated a series of CAR constructs targeting glypican-3 (GPC3), which is selectively expressed on several solid tumors. We compared GPC3-specific CARs that encoded CD3zeta (Gz) alone or with costimulatory domains derived from CD28 (G28z), 4-1BB (GBBz), or CD28 and 4-1BB (G28BBz).
These preliminary results suggest that patients undergoing liver or kidney transplant can be stratified at high risk of EAR according to their CD28 molecule expression on peripheral CD4(+) T lymphocytes.
The rs3116496 (T>C), rs3181098 (G>A) and rs3181100 (G>C) of CD28 were, respectively, found to be correlated with incremental susceptibility to recurrent spontaneous abortion under the allelic model.
Coexpression of CD200R-CD28 enhances function in WT1-specific T-cell receptor - transduced human primary T cells.
the upregulation of others syncytial molecules, including LAG3, CTLA4, CD28 and CD3, assisting the formation of syncytia with APC cells.
our data provide the first evidence of a strict link between the absence of CD28 and the expression of perforin, which is likewise enhanced by the expression of NKG2D, within selected CD4(+) T cells from cervical cancer patients.
Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck complex of protein kinase Ctheta; (PKCtheta;), which serves as a key effector kinase in the CD28 signaling pathway.
The mutant CD28 isoforms could accelerate tumor cell growth.
CD3/28-activated T cells expanded in IL-7 and IL-15 produced greater expansion of memory stem T cells and central memory T cell-derived T cells compared with IL-2. Our strategy provides a powerful tool to elucidate the characteristics of CAR-modified T cells, regardless of the protocol used for expansion, reveals the functional properties of each expanded T cell subset.
identified recurrent mutations in CD28 in peripheral T-cell lymphomas. Molecular modeling studies on each of these mutations suggested how these mutants result in increased affinities.
the scaffolding role of RLTPR predominates during CD28 co-stimulation and underpins the similar function of RLTPR in human and mouse T cells.
the dependency on CD28 for proliferation in each regulatory T cell subset differs depending on the environment.
This study demonstrates that CD28 deficiency results in the generation of germinal-center independent IgM+ experienced B cells and the production of protective IgM during experimental malaria, providing evidence for an additional mechanism by which the immune system controls Plasmodium infection.
CD28 may play a role in LPS nephropathy. Immunofluorescence colocalization analysis revealed a tight association of gammadeltaT cells with B7-1 in the kidney. High B7-1 expression was detected in podocytes treated with LPS.
This work unravels a new regulatory mechanism for CD28 signaling that involves dynamic interplay between acidic phospholipids and Ca2+ to set the local electrostatic environment.
CD28 signaling is required for follicular Treg cell differentiation. Treg-specific deletion of CD28 caused a reduction in TFR cell numbers and function, which resulted in increased germinal center B cells and Ab production. CD28-deficient TFR cells showed a diminished suppressive capacity.
In adoptive therapy of disseminated leukemia, CD200R-CD28-transduced leukemia-specific CD8 T cells eradicated otherwise lethal disease more efficiently than wild-type cells and bypassed the requirement for interleukin-2 administration to sustain in vivo activity.
Study shows that CD28 ligation during priming endows T cells with mitochondrial capacity that is important for future T cell responses. We speculate that CD28 temporarily restricts TXNIP and miR33 expression, and this leads to a transient induction of Cpt1a and fatty acid oxidation, which are marked by characteristic changes in mitochondria shape and structure.
findings revealed a dual mechanism of monocyte and neutrophil recruitment by T cells relying on overlapping and nonoverlapping roles for the noninducible costimulatory receptor CD28 and the inflammatory cytokine TNF
results are consistent with a complex pathway in which CD28 is the primary driver of Treg proliferation and CTLA-4 functions as the main brake but is also dependent on TCR signals and interactions with CD80/CD86.
data suggest that mPEG PV1-Fab' acts mainly on IFN-gamma-producing CD4+ T cells and emphasize that this specific CD28 blockade strategy is a potential specific and alternative tool for the treatment of autoimmune disorders in the eye.
BAFF upregulates CD28/B7 and CD40/CD154 expression, and promotes the interactions between T and B cells in a BAFF-R-dependent manner
Our data show that increasing the number and activation of Treg cells by a superagonistic antibody (CD28SA) is therapeutically effective in experimental arthritis.
we report that cell-intrinsic deletion of CD28 after the peak of the primary response does not affect the establishment, maintenance, or recall of long-term memory. Thus, if given sufficient time, the progeny of primed CD8(+) T cells adapt to the absence of this costimulator.
Deletion of CD28 co-stimulatory signals exacerbates left ventricular remodeling and increases cardiac rupture after MI through prolongation of the inflammatory period and reduction of collagen fiber in the infarct scars.
identified a new plasmacytoid dendritic cells regulatory mechanism by which the same CD28 molecule that promotes stimulation in most cells
Ndrg1 is phosphorylated and degraded by CD28 signalling in a proteasome-dependent manner.
The CD4/CD8 positive lymphocyte count and the expression of CD28 and CD38 antigens in the murine schistosomiasis japonica model are reported.
results suggest a key role for CD28 costimulation in promoting a central Treg to eTreg transition with appropriate upregulation of chemokine receptors such as CCR6 that are required for tissue homing
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, T-cell-specific surface glycoprotein CD28
, CD28 antigen (Tp44)
, T-cell-specific surface glycoprotein CD28 homolog
, T-cell costimulatory molecule CD28
, cell surface protein
, costimulatory molecule B7 receptor CD28
, antigen CD28
, T-cell specific surface glycoprotein CD28
, CD28 precursor protein
, T-cell-specific surface glycoprotein CD28-like protein
, CD28 molecule L homeolog