anti-CBL (CBL) Antikörper

Bezeichnung:: anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence Antikörper (CBL)

Auf www.antikoerper-online.de finden Sie aktuell 285 Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antikörper von 30 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CBL Kits (8) und CBL Proteine (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 322 CBL Produkte verfügbar.

Synonyme:: 4732447J05Rik, C-CBL, c-cbl-like, cbl, Cbl-2, CBL2, FRA11B, NSLL, RGD1561386, RNF55

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	CBL	12402	P22682
	CBL	867	P22681
	CBL	500985
Alle Spezies anzeigen Weitere Synonyme anzeigen

Meistgesuchte Reaktivitäten zu anti-CBL (CBL) Antikörper

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anti-Mouse (Murine) CBL Antikörper:

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Verknüpfte Pathways mit anti-CBL Antikörper

VEGFR1 Specific Signals

Weitere Produktkategorien zu CBL Antikörper

Am meisten referenzierte anti-CBL Antikörper

Chicken Monoclonal CBL Primary Antibody für IF, IP - ABIN967970 : Burke, Schooler, Wiley: Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. in Molecular biology of the cell 2001 (PubMed)
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Chicken Monoclonal CBL Primary Antibody für IF, IP - ABIN967971 : Donovan, Wange, Langdon, Samelson: The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. in The Journal of biological chemistry 1994 (PubMed)
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Human Monoclonal CBL Primary Antibody für ICC, FACS - ABIN968993 : Sproul, Xu, Wilhelm, Gire, Greene: Cbl negatively regulates JNK activation and cell death. in Cell research 2009 (PubMed)
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Human Monoclonal CBL Primary Antibody für ICS - ABIN1176884 : Miura-Shimura, Duan, Rao, Reddi, Shimura, Rottapel, Druker, Tsygankov, Band, Band: Cbl-mediated ubiquitinylation and negative regulation of Vav. in The Journal of biological chemistry 2003 (PubMed)
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Human Monoclonal CBL Primary Antibody für ICS - ABIN1176886 : Thien, Langdon: Cbl: many adaptations to regulate protein tyrosine kinases. in Nature reviews. Molecular cell biology 2001 (PubMed)
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Human Monoclonal CBL Primary Antibody für ICS - ABIN1176885 : Tsygankov, Teckchandani, Feshchenko, Swaminathan: Beyond the RING: CBL proteins as multivalent adapters. in Oncogene 2001 (PubMed)
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Human Monoclonal CBL Primary Antibody für IF, WB - ABIN968810 : Rivero-Lezcano, Sameshima, Marcilla, Robbins: Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. in The Journal of biological chemistry 1994 (PubMed)
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Weitere Antikörper gegen CBL Interaktionspartner

Mouse (Murine) Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Interaktionspartner

Cbl, Cbl-b, and Cbl-c have a role in protecting mammary epithelial cellsfrom proteotoxic stress-induced cell death by promoting turnover of active c-Src
The establishment of a new model of concurrent tissue-selective CBL/CBL-B deletion should allow a clear assessment of the tumor-intrinsic roles of CBL/CBL-B in non-myeloid malignancies and help test the potential for CBL/CBL-B inactivation in immunotherapy of tumors.
These findings highlight a hitherto unexplored and novel role for Cbl and PI3K in modulating the osteogenic response of periosteal cells during the early stages of fracture repair.
c-Cbl negatively regulates IFN-beta (zeige IFNB1 Antikörper) signaling and cellular antiviral response by promoting IRF3 (zeige IRF3 Antikörper) ubiquitination and degradation.
This study demonstrate an unprecedented role for c-Cbl in microglia-mediated neuroinflammation involving PI3K/Akt (zeige AKT1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper) pathway.
These studies reveal a novel, cell-autonomous requirement of CBL and CBL-B in epithelial stem cell maintenance during organ development and remodeling through modulation of mTOR (zeige FRAP1 Antikörper) signaling.
mutant CBL proteins effectively compete with the remaining wild type CBL-B and juxtapose tyrosine kinase (zeige TYRO3 Antikörper)-binding domain-associated protein tyrosine kinases with proline-rich region-associated signaling proteins to hyper-activate signaling downstream of hematopoietic growth factor (zeige IL-3 Antikörper) receptors
results demonstrate that c-Cbl mediates the ubiquitination/degradation of integrin beta1, which leads to COMP (zeige COMP Antikörper) deficiency-induced dilated cardiomyopathy.
Gem (zeige GEM Antikörper), a gene encoding a GTPase (zeige RACGAP1 Antikörper) that is upregulated by Cbl(Q367P) , enhanced hematopoietic stem cell activity and induced myeloid cell proliferation. In addition, Evi1 (zeige MECOM Antikörper), a gene encoding a transcription factor, was found to cooperate with Cbl(Q367P) and progress CMML to AML (zeige RUNX1 Antikörper).
Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.

Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Interaktionspartner

Two germline de novo mutations in CBL were identified in patients with infancy-onset severe Moyamoya angiopathy who also presented subtle signs of RASopathy.
Patients harbouring ASXL1 (zeige ASXL1 Antikörper) and/or CBL mutations (n = 8, 8 deaths, median OS = 11 months) had a significantly worse OS as compared to those without either mutation (n = 11, 4 deaths, median OS = 84 months) (P = 0.0002) (Fig 1a).
the loss of c-Cbl activity significantly enhanced nuclear beta-catenin (zeige CTNNB1 Antikörper) and colorectal cancer tumor growth in cell culture and a mouse xenograft model.
we have shown that c-CBL plays a supportive role in the proliferation, migration and invasion of human melanoma cells.
Findings show for this first time that ATG9A (zeige ATG9A Antikörper) loss in trastuzumab resistant cells allowed Her2 (zeige ERBB2 Antikörper) to escape from lysosomal targeted degradation through K63 poly-ubiquitination via c-Cbl.
c-Cbl negatively regulates IFN-beta (zeige IFNB1 Antikörper) signaling and cellular antiviral response by promoting IRF3 (zeige IRF3 Antikörper) ubiquitination and degradation.
These results suggest MET overexpression is related to altered c-CBL expression in head and neck squamous cell carcinoma, which may influence tumorigenesis
This study identified a new regulatory axis in which miR (zeige MLXIP Antikörper)-124-3p and CBL regulate the proliferation and invasion of breast cancer cells.
The viral entry receptor Nectin-1 (zeige PVRL1 Antikörper) is also internalized during HSV-1 infection in a Cbl-dependent mechanism, and that increases the opportunity of the virus to spread to uninfected cells.
mutant CBL proteins effectively compete with the remaining wild type CBL-B and juxtapose tyrosine kinase (zeige TXK Antikörper)-binding domain-associated protein tyrosine kinases with proline-rich region-associated signaling proteins to hyper-activate signaling downstream of hematopoietic growth factor (zeige IL-3 Antikörper) receptors

CBL Antigen-Profil

Beschreibung des Gens

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Alternative names and synonyms associated with CBL

Casitas B-lineage lymphoma (Cbl) Antikörper
Cbl proto-oncogene (CBL) Antikörper
Cbl proto-oncogene (Cbl) Antikörper

4732447J05Rik Antikörper
C-CBL Antikörper
c-cbl-like Antikörper
cbl Antikörper
Cbl-2 Antikörper
CBL2 Antikörper
FRA11B Antikörper
NSLL Antikörper
RGD1561386 Antikörper
RNF55 Antikörper

Bezeichner auf Proteinebene für CBL

E3 ubiquitin-protein ligase CBL , casitas B-lineage lymphoma proto-oncogene , proto-oncogene c-CBL , signal transduction protein CBL , Cas-Br-M (murine) ecotropic retroviral transforming sequence , RING finger protein 55 , fragile site, folic acid type, rare, fra(11)(q23.3) , oncogene CBL2 , proto-oncogene c-Cbl , Casitas B-lineage lymphoma

GENE ID	SPEZIES
12402	Mus musculus
867	Homo sapiens
489369	Canis lupus familiaris
100518854	Sus scrofa
527418	Bos taurus
500985	Rattus norvegicus

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Show all anti-Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Antikörper with Pubmed References

Mouse (Murine) Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Interaktionspartner

Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with CBL

Bezeichner auf Proteinebene für CBL