anti-CBL Antikörper

Protein Überblick

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Alternative names and synonyms associated with CBL

• Casitas B-lineage lymphoma (Cbl) Antikörper
• Cbl proto-oncogene (CBL) Antikörper
• Cbl proto-oncogene (Cbl) Antikörper

• 4732447J05Rik Antikörper
• C-CBL Antikörper
• c-cbl-like Antikörper
• cbl Antikörper
• Cbl-2 Antikörper
• Alle Synonyme
• CBL2 Antikörper
• FRA11B Antikörper
• NSLL Antikörper
• RGD1561386 Antikörper
• RNF55 Antikörper

Bezeichner auf Proteinebene für CBL

E3 ubiquitin-protein ligase CBL , casitas B-lineage lymphoma proto-oncogene , proto-oncogene c-CBL , signal transduction protein CBL , Cas-Br-M (murine) ecotropic retroviral transforming sequence , RING finger protein 55 , fragile site, folic acid type, rare, fra(11)(q23.3) , oncogene CBL2 , proto-oncogene c-Cbl , Casitas B-lineage lymphoma