anti-CBL (CBL) Antikörper

Mouse (Murine) Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Interaktionspartner

1. Cbls were highly expressed in GC light zone (LZ) B cells, where they promoted the ubiquitination and degradation of Irf4, a transcription factor facilitating PC fate choice.

2. Cbl, Cbl-b, and Cbl-c have a role in protecting mammary epithelial cellsfrom proteotoxic stress-induced cell death by promoting turnover of active c-Src

3. The establishment of a new model of concurrent tissue-selective CBL/CBL-B deletion should allow a clear assessment of the tumor-intrinsic roles of CBL/CBL-B in non-myeloid malignancies and help test the potential for CBL/CBL-B inactivation in immunotherapy of tumors.

4. These findings highlight a hitherto unexplored and novel role for Cbl and PI3K in modulating the osteogenic response of periosteal cells during the early stages of fracture repair.

5. c-Cbl negatively regulates IFN-beta signaling and cellular antiviral response by promoting IRF3 ubiquitination and degradation.

6. This study demonstrate an unprecedented role for c-Cbl in microglia-mediated neuroinflammation involving PI3K/Akt/NF-kappaB pathway.

7. c-Cbl's linker helix region mutations are only oncogenic when they disrupt the native state and fail to ubiquitinate protein tyrosine kinases.

8. These studies reveal a novel, cell-autonomous requirement of CBL and CBL-B in epithelial stem cell maintenance during organ development and remodeling through modulation of mTOR signaling.

9. mutant CBL proteins effectively compete with the remaining wild type CBL-B and juxtapose tyrosine kinase-binding domain-associated protein tyrosine kinases with proline-rich region-associated signaling proteins to hyper-activate signaling downstream of hematopoietic growth factor receptors

10. results demonstrate that c-Cbl mediates the ubiquitination/degradation of integrin beta1, which leads to COMP deficiency-induced dilated cardiomyopathy.

11. Gem, a gene encoding a GTPase that is upregulated by Cbl(Q367P) , enhanced hematopoietic stem cell activity and induced myeloid cell proliferation. In addition, Evi1, a gene encoding a transcription factor, was found to cooperate with Cbl(Q367P) and progress CMML to AML.

12. Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.

13. Cbl down-regulation protects mice against high-fat diet-induced obesity and insulin resistance.

14. Cbl-b and c-Cbl regulate the degradation of Osterix through the ubiquitin-proteasome pathway.

15. Overexpression of Smad7 in human HaCaT keratinocyte cells and mouse skin tissues elevated EGF receptor (EGFR) activity by impairing ligand-induced ubiquitination and degradation of activated receptor, which is induced by the E3 ubiquitin ligase c-Cbl.

16. Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor

17. Whereas Cbl-PI3K interaction regulates differentiation and survival, bone resorption is predominantly regulated by Cbl-b in osteoclasts.

18. c-Cbl activation promotes myocyte apoptosis, inhibits angiogenesis, and causes adverse cardiac remodeling after myocardial infarction.

19. Data indicate a Cbl/p85/epsin-1 pathway in erythropoietin receptor (EpoR) endocytosis.

20. These results support the notion that the distal cytoplasmic domain of CD5, including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via c-Cbl.

Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) Interaktionspartner

1. CBL gene status could be a potential target and indicator for MET inhibitors and future RTK regulation investigations, especially in those that will look into whether CBL should be evaluated before RTK inhibitors are considered.

2. The LMP2A of Epstein-Barr Virus was found to interfer with cofilin degradation in nasopharyngeal cancer cells by accelerating the proteasomal degradation of Cbl and Syk.

3. The host-Mycobacterium tuberculosis (Mtb) interaction map revealed two factors involved in Mtb pathogenesis-the secreted Mtb protein, LpqN, and its binding partner, the human ubiquitin ligase CBL.

4. C-CBL is likely to play a tumor suppressive role by antagonizing a robust oncogenic signaling driven by c-Src.

5. Our results suggested that c-Cbl can reverse tamoxifen resistance in HER2-overexpressing breast cancer cells

6. Study provided evidence suggesting that Cbl can positively control GM-CSF-induced JAK2 activation and signaling through JAK2 ubiquitination.

7. Cbl-b and c-Cbl downregulate PD-L1 in EGFR wild-type non-small cell lung cancer

8. Authors observed that delta-catenin plays a key role in EGFR stability and downstream signaling. delta-Catenin competes with c-Cbl for EGFR binding, which results in a reduction of binding between c-Cbl and EGFR and thus decreases the ubiquitination of EGFR.

9. its mutation is genetic predictor of tumor reduction in glucocorticoid-treated patients with chronic myelomonocytic leukemia.

10. c-CBL might play a role in the pathogenesis of inflammatory dermatoses and cutaneous T-cell lymphoma

11. Two germline de novo mutations in CBL were identified in patients with infancy-onset severe Moyamoya angiopathy who also presented subtle signs of RASopathy.

12. Patients harbouring ASXL1 and/or CBL mutations (n = 8, 8 deaths, median OS = 11 months) had a significantly worse OS as compared to those without either mutation (n = 11, 4 deaths, median OS = 84 months) (P = 0.0002) (Fig 1a).

13. the loss of c-Cbl activity significantly enhanced nuclear beta-catenin and colorectal cancer tumor growth in cell culture and a mouse xenograft model.

14. we have shown that c-CBL plays a supportive role in the proliferation, migration and invasion of human melanoma cells.

15. Findings show for this first time that ATG9A loss in trastuzumab resistant cells allowed Her2 to escape from lysosomal targeted degradation through K63 poly-ubiquitination via c-Cbl.

16. c-Cbl negatively regulates IFN-beta signaling and cellular antiviral response by promoting IRF3 ubiquitination and degradation.

17. These results suggest MET overexpression is related to altered c-CBL expression in head and neck squamous cell carcinoma, which may influence tumorigenesis

18. This study identified a new regulatory axis in which miR-124-3p and CBL regulate the proliferation and invasion of breast cancer cells.

19. The viral entry receptor Nectin-1 is also internalized during HSV-1 infection in a Cbl-dependent mechanism, and that increases the opportunity of the virus to spread to uninfected cells.

20. mutant CBL proteins effectively compete with the remaining wild type CBL-B and juxtapose tyrosine kinase-binding domain-associated protein tyrosine kinases with proline-rich region-associated signaling proteins to hyper-activate signaling downstream of hematopoietic growth factor receptors