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the p (zeige CAPS ELISA Kits)referential binding of CAPS1 to open syntaxin-1 can (zeige STX1A ELISA Kits) contribute to the stabilization of the open state of syntaxi (zeige UNC13A ELISA Kits)n-1 during its transition from "closed" state to the SNA (zeige STX1A ELISA Kits)RE complex formation.
Increased level of CADPS protein, human in Schizophrenic patients
Loss of CADPS is associated with central nervous system primitive neuroectodermal tumor.
Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor (zeige DRD2 ELISA Kits) and calcium-dependent activator protein for secretion (CAPS (zeige CAPS ELISA Kits)).
edited CAPS1 (zeige CAPS ELISA Kits) bound preferentially to the activated form of syntaxin-1A (zeige STX1A ELISA Kits), a component of the exocytotic fusion complex.
CAPS1 (zeige CAPS ELISA Kits) protein plays an important role during protein release from secretory granules in hippocampal neurons. The cytosolic protein CAPS1 (zeige CAPS ELISA Kits) regulates several stages of secretory granule processing.
identified a specific interaction of CAPS1 (zeige CAPS ELISA Kits) with septin (zeige SEPT6 ELISA Kits) family proteins; demonstrated that the C-terminal region of the CAPS1 (zeige CAPS ELISA Kits) protein binds to part of the deduced GTP-binding (zeige RND2 ELISA Kits) domain of septin (zeige SEPT6 ELISA Kits) proteins.
data indicate that CAPS-1 promotes fusion competence of immobile (tethered) DCVs in presynaptic terminals and that CAPS-1 localization to DCVs is probably not essential for this role
Naturally occurring splice variants of CAPS2 (zeige CADPS2 ELISA Kits) in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 (zeige CADPS2 ELISA Kits) primes vesicles independently of its MUN domain.
Loss of CAPS1 (zeige CAPS ELISA Kits) disrupts the trans-Golgi network-dense-core vesicle pathway.
CAPS1 (zeige CAPS ELISA Kits) binds to the full-length of cytoplasmic syntaxin-1 (zeige STX1A ELISA Kits) with preference to its "open" conformation, whereas Munc13-1 (zeige UNC13A ELISA Kits) binds to the first 80 N-terminal residues of syntaxin-1 (zeige STX1A ELISA Kits).
CAPS (zeige CAPS ELISA Kits) family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis
a functional role for CAPS1 (zeige CAPS ELISA Kits) in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4 (zeige ARF4 ELISA Kits)/ARF5 (zeige ARF5 ELISA Kits) in a GDP-dependent manner.
CAPS1 (zeige CAPS ELISA Kits) has a role in constitutive and regulated exocytosis but not in loading of transmitters into dense core vesicles
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.
, Ca2+-dependent activator protein for secretion
, Ca2+-dependent secretion activator
, Ca2+-regulated cytoskeletal protein
, calcium-dependent activator protein for secretion 1
, calcium-dependent secretion activator 1
, Ca2+-dependent activator protein
, Ca<2+-dependent activator protein for secretion
, Ca<2+>dependent activator protein for secretion
, Ca++-dependent secretion activator
, calcium-dependent secretion activator 1-like