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Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN2005039
Lee, Choi, Lee: Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
Rat (Rattus) SNCA Protein expressed in Rabbit - ABIN1742284
Jüttner, Moré, Das, Babich, Meier, Henning, Erdmann, Mu Ller, Otto, Grantyn, Rathjen: Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. in Neuron 2005
study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg) during embryogenesis
These results indicated that integrin CD11b (zeige ITGAM Proteine) mediates alpha-synuclein-induced NOX2 (zeige CYBB Proteine) activation through a RhoA (zeige RHOA Proteine)-dependent pathway.
High SNCA expression is associated with Parkinson's disease.
Snca regulates bone network homeostasis and ovariectomy-induced bone loss
These findings provide evidence for a novel mechanism underlying the protective effects of PINK1 (zeige PINK1 Proteine) against alpha-syn-induced neurodegeneration and highlight a novel therapeutic target for Parkinson's disease treatment.
study demonstrates that PLK-2 activity can rapidly change cellular alpha-synuclein levels in cell models and in mice brains, but this process does not require phosphorylation of S129. Instead, it operates via regulation of alpha-synuclein mRNA transcription in an open reading frame-dependent manner
the presented data link the Parkinson's disease-associated gene alpha-synuclein to the neuronal cell fate determinant TRIM32 (zeige TRIM32 Proteine).
alpha-synuclein levels can be reduced in neurons without impairing (or improving) mitochondrial bioenergetics or distribution
Study shows that the age-dependent alpha-syn accumulation is correlated with an elevation of TRPC3 in the mitochondrial fractions isolated from monkey and mouse brains. In animal and cell models, alpha-syn overexpression was accompanied by an elevation of alpha-syn and TRPC3 in the mitochondrial fractions, and alpha-syn downregulation was associated with a reduction of the mitochondrial alpha-syn and TRPC3.
plasma concentrations of alpha-synuclein were significantly higher in exercising mice compared to control mice. Our results suggest that exercise may slow the progression of Parkinson's disease by preventing abnormal protein aggregation in brain
revealed a prominent modulating effect of alpha-synuclein on the developing DA neurons in substantia nigra (SN) which is the most affected region in PD patients. Yet, alpha-synuclein had no effect on the formation of DA neurons in ventral tegmental area which is much less susceptible to degeneration in PD patients.
This study demonstrated that the plp and alpha-synuclein transgenic mouse model of multiple system atrophy showed the Progressive striatonigral degeneration.
PD-1 (zeige PDCD1 Proteine) rs2227982 C>T and PD-L1 (zeige CD274 Proteine) rs4143815 C>G polymorphisms increased the risk of ovarian cancer, leading to a poor prognosis, associated with low expressions of PD-1 (zeige PDCD1 Proteine) and PD-L1 (zeige CD274 Proteine).
We expected that in vitro PD1 (zeige PDCD1 Proteine)/PD-L1 (zeige CD274 Proteine) signal that has been optimized in this study will serve as a valuable protocol for preclinical studies involving PD1 (zeige PDCD1 Proteine)/PD-L1 (zeige CD274 Proteine) pathway.
Both mutants A18T and A29S are aggregation prone and undergo rapid aggregation compared to wild-type alpha-synuclein. A18T mutant followed faster aggregation kinetics compared to A29S substitution. Substitution of alanine at the 18th position is highly sensitive compared to adjacent positions.
alpha-Syn bound to PP2A (zeige PPP2R4 Proteine) Calpha (zeige PRKACA Proteine) by the hydrophobic interaction and upregulated its activity. Blocking the hydrophobic domain of alpha-Syn or hydrophilic mutation on the residue I123 in PP2A (zeige PPP2R4 Proteine) Calpha (zeige PRKACA Proteine) all reduced PP2A (zeige PPP2R4 Proteine) activity upregulation by alpha-Syn.
This is the first study to investigate the association of rs3910105 in SNCA [SNCA protein, human] with DAT [dopamine transporter] availability. rs3910105 had an effect on DAT availability, and the correlation between DAT availability and SNCA transcripts were significant in CT [computed tomography] genotypes of rs3910105.
pooled analysis showed that there is a significant association between rs2736990 polymorphism of SNCA and Parkinson's disease susceptibility in all genetic models
Tctex1 overexpression promoted autophagy lysosome fusion and effectively degraded alpha-synuclein with increased cell activity
Rapid eye movement sleep behavior disorder was associated with rs3756063 located in the 5' region of SNCA
lipid dyshomeostasis by GBA1 (zeige GBA Proteine) deficiency leads to decreased alpha-synuclein tetramers and increased alpha-synuclein monomers, which may provide the building blocks for phospho-Ser129-positive aggregates in GBA1 (zeige GBA Proteine)-Parkinson's disease induced pluripotent stem cell-derived dopaminergic neurons
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (zeige TNFAIP1 Proteine) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, alpha SYN
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein