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Rat (Rattus) SNCA Protein expressed in Rabbit - ABIN1742284
Jüttner, Moré, Das, Babich, Meier, Henning, Erdmann, Mu Ller, Otto, Grantyn, Rathjen: Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. in Neuron 2005
Human SNCA Protein expressed in Escherichia coli (E. coli) - ABIN2005039
Lee, Choi, Lee: Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form. in The Journal of biological chemistry 2002
Show all 2 Pubmed References
study examined the spatial and temporal expression patterns of three synuclein genes (snca, sncbb, sncg) during embryogenesis
Cardiolipin exposure on the outer mitochondrial membrane modulates alpha-synuclein in Parkinson's disease and cultured cardiomyocyte models.
A53T SNCA missense mutation caused impaired light entrainment of the circadian system in mice.
Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in alpha-Synuclein Aggregation Disorders
In this study, we assessed the spread of pathology following a localized induction of alphaS inclusions in the lumbar spinal cord following a unilateral injection in the sciatic nerve. Using this paradigm, we demonstrated the ability for alphaS inclusion spread and/or induction along neuroanatomical tra (zeige PRNP Proteine)cts within the CNS of two alphaS-overexpressing mouse models.
These results indicated that integrin CD11b (zeige ITGAM Proteine) mediates alpha-synuclein-induced NOX2 (zeige CYBB Proteine) activation through a RhoA (zeige RHOA Proteine)-dependent pathway.
High SNCA expression is associated with Parkinson's disease.
Snca regulates bone network homeostasis and ovariectomy-induced bone loss
These findings provide evidence for a novel mechanism underlying the protective effects of PINK1 (zeige PINK1 Proteine) against alpha-syn-induced neurodegeneration and highlight a novel therapeutic target for Parkinson's disease treatment.
study demonstrates that PLK-2 activity can rapidly change cellular alpha-synuclein levels in cell models and in mice brains, but this process does not require phosphorylation of S129. Instead, it operates via regulation of alpha-synuclein mRNA transcription in an open reading frame-dependent manner
the presented data link the Parkinson's disease-associated gene alpha-synuclein to the neuronal cell fate determinant TRIM32 (zeige TRIM32 Proteine).
We have also demonstrated that UCHL1 (zeige UCHL1 Proteine) S-nitrosylation provides seeding for faster aggregation of a-synuclein. Finally, the in vitro nitrosylation of UCHL1 (zeige UCHL1 Proteine) was corroborated with rotenone induced mouse model of PD
The results of this pilot study suggest that quantitative measurement of immunoreactivity to alpha-synuclein in nerve fibers from minor salivary glands in Parkinson's disease.
PD-1 (zeige PDCD1 Proteine) expression was augmented on CD8 (zeige CD8A Proteine)+ T cells in BALF of a patient with smoldering adult T-cell lymphoma and Pneumocystis jiroveci pneumonia. This suggested that the PD-1 (zeige PDCD1 Proteine)-PD-L1 (zeige CD274 Proteine) system may suppress not only antitumor immunity but also host defense against pathogens and thereby allow establishment of chronic HTLV-1 infection and immunodeficiency.
Extracellular alpha-synuclein induces sphingosine S1P1R uncoupled from inhibitory G-protein leaving beta-arrestin signal intact.
Study concludes that the cortical excitability profile of patients with mutations in the alpha-synuclein gene (SNCA) is akin to patients with the akinetic form of sporadic Parkinson disease.
These results suggest that alpha-syn increases FoxO3a (zeige FOXO3 Proteine) expression as a result of its intrinsic ferrireductase activity. The results also suggest that FoxO3a (zeige FOXO3 Proteine) plays a pivotal role in the toxicity of both Fe(II) and toxic alpha-syn species to neuronal cells
dysregulation of the extended alpha-SYN 3'UTR might contribute to the pathogenesis of Parkinson's disease.
PD-1 (zeige PDCD1 Proteine) knockout combined with hTERT transduction could prolong the lifespan and enhance antitumor efficacy of CIK cells against hepatocellular carcinoma cell line.
We find evidence that the high-frequency peak in the amide-I spectrum of alpha-synuclein (alphaS)fibrils involves a normal mode that differs fundamentally from the canonical high-frequency antiparallel beta-sheet mode. The high sensitivity of the fibril structure to the ionic strength might form the basis of differences in alphaS-related pathologies.
analysis of membrane curvature sensing by amphipathic helices using alpha-synuclein and annexin B12 (zeige TNFAIP1 Proteine) [ANXB12]
Immunocytochemistry shows alpha synuclein localized to the Golgi apparatus and vesicles of bovine adrenal medullary chromaffin cells, consistent with its putative role in vesicular function within synapses.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
, alpha SYN
, non-A beta component of AD amyloid
, non-A4 component of amyloid
, non A-beta component of AD amyloid
, synuclein alpha-140
, alpha synuclein