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Mammalian Monoclonal KCNB1 Primary Antibody für ISt, IHC - ABIN1304758
Krasowska, Zabłocki, Górecki, Swinny: Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice: implications for cognitive impairment in duchenne muscular dystrophy. in PLoS ONE 2014
Show all 74 Pubmed References
Mammalian Monoclonal KCNB1 Primary Antibody für ISt, IHC - ABIN1304759
Mohapatra, Siino, Trimmer: Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2.1 channel. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Show all 13 Pubmed References
The results of this study shown the disruption of KV2.1 somato (zeige SSTR5 Antikörper)-dendritic clusters prevents the apoptogenic increase of potassium currents.
KCNB1 oxidation may favor integrin clustering, thereby facilitating the recruitment and activation of FAK (zeige PTK2 Antikörper) and Src (zeige SRC Antikörper)/Fyn (zeige FYN Antikörper) kinases.
Spinal Musculature Atrophy motor neurons showed a lower surface expression of Kv2.1 potassium channels and reduced spiking ability.
This study provides the first experimental evidence that oxidation of a K(+) channel (zeige KCNC4 Antikörper) constitutes a mechanism of neuronal and cognitive impairment in vertebrates. Specifically, the interaction of KCNB1 channels with reactive oxygen species plays a major role in the etiology of mouse model of traumatic brain injury (TBI), a condition associated with extensive oxidative stress. In addition, a Food and Drug Administration-app (zeige APP Antikörper)
The AMIGO1-KCNB1 complex is involved in schizophrenia-related behavioral domains in mice.
major finding from this study is the novel region- and cell-specific relationship between the localization of the plasma membrane Kv2.1 channel and intracellular RyR (zeige RYR1 Antikörper) Ca2 (zeige CA2 Antikörper)+ release channels
study supports the concept that transcriptional suppression of KV2.1 by activation of the AKAP150 (zeige AKAP5 Antikörper)-CaN/NFATc3 (zeige NFATC3 Antikörper) signaling axis contributes to enhanced arterial tone during diabetes
These results showed that a modest suppression of Kv2.1 channels dramatically raises insulinotropic potency of GLP-1 (zeige GCG Antikörper)-based drugs.
Kv2.1 knockout mice are strikingly hyperactive, defective in spatial learning and hypersensitive to convulsants.
the accumulation of KCNB1 oligomers in the membrane disrupts planar lipid raft integrity and causes apoptosis via activating the c-Src (zeige SRC Antikörper)/JNK (zeige MAPK8 Antikörper) signaling pathway.
The results of this study support the conclusion that the KCNB1 variants described here are likely to be pathogenic in patient with Neurodevelopmental Disorders.
Data suggest that NMDAR (zeige GRIN1 Antikörper) plays key role in mediating effect of leptin (zeige LEP Antikörper) to modulate function of insulin (zeige INS Antikörper)-secreting cells by promoting AMPK (zeige PRKAA1 Antikörper)-dependent trafficking of KATP and Kv2.1 channels to plasma membrane. (NMDAR (zeige GRIN1 Antikörper) = N-methyl-D-aspartate receptor (zeige GRIN1 Antikörper); AMPK (zeige PRKAA1 Antikörper) = AMP-activated protein kinase (zeige PRKAA2 Antikörper); KATP = ATP-sensitive potassium channel (zeige KCNAB2 Antikörper); Kv2.1 = delayed-rectifier potassium channel 1)
Kv2.1, but not Kv2.2 (KCNB2 (zeige KCNB2 Antikörper)), forms clusters of 6-12 tetrameric channels at the plasma membrane and facilitates insulin (zeige INS Antikörper) exocytosis. Knockdown of Kv2.1 expression reduces secretory granule targeting to the plasma membrane. KCNB1 appears reduced in T2D islets, and further knockdown of KCNB1 does not inhibit Kv current in T2D beta-cells. Upregulation of Kv2.1-wild-type, but not Kv2.1-DeltaC318, rescues the exocytotic phen...
the first six N-terminal residues including Lys (zeige LYZ Antikörper)-3, Lys (zeige LYZ Antikörper)-4, and Leu-5 (zeige TRIM13 Antikörper) are critical for controlling functional regulation, but not trafficking, of BK channels. This membrane-distal region has features of an amphipathic helix that is predicted to control the orientation of the first transmembrane-spanning domain (TM1 (zeige TPM2 Antikörper)) of the beta1-subunit.
Perifosine modified the Kv2.1 inactivation gating resulting in a decrease of the current amplitude.
KCNB1 is a strong susceptibility gene for schizophrenia spectrum disorders in humans.
inactivation regulation via Ca(2 (zeige CA2 Antikörper)+)/calmodulin does not interfere with the beta subunit's enzymatic activity as an NADPH (zeige NQO1 Antikörper)-dependent oxidoreductase (zeige TXNRD1 Antikörper), thus rendering the Kvb1.1 subunit a multifunctional receptor
Kv2.1 functional aberrations in humans are associated with developmental delay, infantile generalized seizures, hypotonia, and behavioural problems, and also highlight a critical role for Kv2.1 in regulating neuronal firing in neuronal circuits.
Epileptic V378A variant in KCNB1 changes ion selectivity, trafficking and expression of Kv2.1 channel.
KCNE5 (zeige KCNE1L Antikörper) subunits may affect Kv2.1 homotetramers and Kv2.1/Kv6.4 (zeige Kcng4 Antikörper) heterotetramers in vivo, resulting in more tissue-specific fine-tuning mechanisms.
Analysis of the data suggested that Kv2.1 channels contribute significantly to the voltage-gated potassium current in smooth muscle cells from rabbit urethra.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.
Voltage-gated potassium channel subunit Kv2.1
, potassium voltage-gated channel subfamily B member 1
, potassium voltage-gated channel, Shab-related subfamily, member 1
, voltage gated potassium channel subtype 2.1
, potassium voltage-gated channel subfamily B member 1-like
, delayed rectifier potassium channel 1
, voltage-gated potassium channel subunit Kv2.1
, potassium channel Kv2.1
, delayed rectifier potassium channel Kv2.1
, h-DRK1 K(+) channel
, potassium channel protein DRK1
, voltage-gated potassium channel Kv2.1