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anti-Mouse (Murine) Gephyrin Antikörper:
anti-Rat (Rattus) Gephyrin Antikörper:
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Chicken Monoclonal Gephyrin Primary Antibody für IF, IP - ABIN968051
Feng, Tintrup, Kirsch, Nichol, Kuhse, Betz, Sanes: Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. in Science (New York, N.Y.) 1998
Show all 4 Pubmed References
Chicken Monoclonal Gephyrin Primary Antibody für IF, IP - ABIN968050
Meyer, Kirsch, Betz, Langosch: Identification of a gephyrin binding motif on the glycine receptor beta subunit. in Neuron 1995
Show all 4 Pubmed References
Chicken Monoclonal Gephyrin Primary Antibody für IF, IP - ABIN968898
Prior, Schmitt, Grenningloh, Pribilla, Multhaup, Beyreuther, Maulet, Werner, Langosch, Kirsch: Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. in Neuron 1992
Show all 2 Pubmed References
Ablation of gephyrin result in the forebrain-specific loss of postsynaptic gamma2-GABAA (zeige GABRg1 Antikörper) receptors, reduces LTP (zeige SCP2 Antikörper) and network excitability in the dentate gyrus.
adult mice lacking interleukin-1 receptor 1 (zeige IL1RL1 Antikörper) (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95 (zeige DLGAP2 Antikörper)) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus.
The results demonstrate that formation of GABAergic synapses containing a postsynaptic gephyrin scaffold is crucial for morphological differentiation, synaptic integration, and long-term survival of adult-born granule cells/
Data suggest that KIF5 regulates gephyrin sorting by a mechanism that involves GSK3 activity.
Pin1 (zeige PIN1 Antikörper)-dependent signaling represents a mechanism to modulate GABAergic transmission by regulating NL2 (zeige MMEL1 Antikörper)/gephyrin interaction.
These results reveal a homeostatic mechanism through which activity regulates the dynamics and function of perisomatic inhibitory synapses, and they identify a CaMKII (zeige CAMK2G Antikörper)-dependent phosphorylation site on gephyrin.
study reveals that palmitoylation of gephyrin by DHHC-12 contributes to dynamic and functional modulation of GABAergic synapses
Within this network, collybistin (zeige Arhgef9 Antikörper) can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin to plasma membrane phosphoinositides.
these findings suggest that gephyrin may be a key factor in BDNF (zeige BDNF Antikörper)-dependent GABAAR (zeige GABRG2 Antikörper) regulation in the amygdala.
Data suggest that the loss of neurotransmitter receptor (zeige GRIN1 Antikörper) clustering at inhibitory synapses causes the early lethality of gephyrin deficient mice.
This study shown that the SNPs located in the rs723432 (Pallele=0.007; uncorrected) in the GPHN gene showed associated with Japanese individuals affected with schizophrenia.
these data reveal that IQSEC3 (zeige IQSEC3 Antikörper) acts together with gephyrin to regulate inhibitory synapse development.
A missense mutation of gephyrin that was unable to synthesize MoCo and activate MoCo-dependent enzymes was identified.
A yin-yang haplotype pattern encompassing gephyrin consists of 284 divergent nucleotide states and both variants vary drastically from their mutual ancestral haplotype, suggesting rapid evolution.
The N-terminal region of GABRA3 (zeige GABRA3 Antikörper) and the GlyR beta subunit (zeige POLG Antikörper) occupies the same binding site of gephyrin.
Results show that PKC (zeige PRRT2 Antikörper)-dependent phosphorylation of GAP43 (zeige GAP43 Antikörper) plays a critical role in regulating postsynaptic gephyrin aggregation in developing GABAergic synapses.
Structural exonic microdeletions affecting the GPHN gene constitute a rare genetic risk factor for IGE and other neuropsychiatric disorders by an impairment of the GABAergic inhibitory synaptic transmission.
The enhancement of Cb-induced gephyrin clustering by GTP (zeige AK3 Antikörper)-TC10 (zeige RHOQ Antikörper) does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors
abnormal accumulations of gephyrin are highly correlated with the neuropathologic diagnosis of Alzheimer disease in 17 AD versus 14 control cases. Furthermore, gephyrin accumulations were specific for AD.
Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures.
duplicated gephyrin genes mediate Moco biosynthesis and control postsynaptic clustering of glycine receptor (zeige GLRB Antikörper)
This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described\; however, the full-length nature of all transcript variants is not currently known.
, putative glycine receptor-tubulin linker protein
, LOW QUALITY PROTEIN: gephyrin