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SUPT5H Produkte

(Transcription Elongation Factor SPT5 (SUPT5H))
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

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Ausgewählte SUPT5H Kategorien

SUPT5H Antikörper

High quality antibodies with extensive validation data.

SUPT5H ELISA Kits

Reliable ELISA kits for a wide range of species.

SUPT5H Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene SUPT5H Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC, IF
Validierungen
  • (6)
Kat. Nr. ABIN7270878
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF, IHC (p)
Validierungen
  • (4)
Kat. Nr. ABIN520620
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Applikation WB, IHC, IHC (p)
Validierungen
  • (3)
Kat. Nr. ABIN6735860
Menge 100 μL
Datenblatt Datenblatt

Empfohlene SUPT5H ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method
Validierungen
Kat. Nr. ABIN1162213
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1162214
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Chicken
Analytical Method
Validierungen
Kat. Nr. ABIN1162212
Menge 96 tests
Datenblatt Datenblatt

Empfohlene SUPT5H Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1321917
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3095662
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3131899
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren SUPT5H Produkten

Lu, Xue, Xue, Yu, Arias, Lin, Fong, Faure, Weisburd, Ji, Mercier, Sutton, Luo, Gao, Zhou: "Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism." in: eLife, Vol. 4, pp. e06535, (2015) (PubMed).

Arabi, Ullah, Branca, Johansson, Bandarra, Haneklaus, Fu, Ariës, Nilsson, Den Boer, Pokrovskaja, Grandér, Xiao, Rocha, Lehtiö, Sangfelt: "Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway." in: Nature communications, Vol. 3, pp. 976, (2012) (PubMed).

Willmann, Milosevic, Pauklin, Schmitz, Rangam, Simon, Maslen, Skehel, Robert, Heyer, Schiavo, Reina-San-Martin, Petersen-Mahrt: "A role for the RNA pol II-associated PAF complex in AID-induced immune diversification." in: The Journal of experimental medicine, Vol. 209, Issue 11, pp. 2099-111, (2012) (PubMed).

Ueki, Lin, Senoo, Ebihara, Agata, Onji, Saheki, Kawai, Mukherjee, Reichenberger, Olsen: "Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice." in: Cell, Vol. 128, Issue 1, pp. 71-83, (2007) (PubMed).

Amir-Zilberstein, Ainbinder, Toube, Yamaguchi, Handa, Dikstein: "Differential regulation of NF-kappaB by elongation factors is determined by core promoter type." in: Molecular and cellular biology, Vol. 27, Issue 14, pp. 5246-59, (2007) (PubMed).

Synonyme und alternative Namen zu SUPT5H

SPT5 homolog, DSIF elongation factor subunit (SUPT5H), transcription elongation factor SPT5 (LOC413814), Transcription elongation factor Spt5 (AT2G34210), transcription elongation factor Spt5 (spt5), transcription elongation factor spt5 (MGYG_08422), transcription elongation factor spt5 (TERG_05483), hypothetical protein (PGTG_18458), SPT5 homolog, DSIF elongation factor subunit (supt5h), SPT5 homolog, DSIF elongation factor subunit (Supt5h), SPT5 homolog, DSIF elongation factor subunit S homeolog (supt5h.S), CG7626 gene product from transcript CG7626-RA (Spt5), Transcription elongation factor SPT5 (spt-5), transcription elongation factor (SPT5), CaO19.1453, CG7626, dDSIF, Dmel\\CG7626, DSIF, Dspt5, dSpt5, etID10129.15, etID37101.15, F13P17.5, F13P17_5, fb37g01, fb95e05, fog, foggy, SPT5, Spt5, spt5, SPT5H, spt5h, Tat-CT1, tat-ct1, wu:fb37g01, wu:fb95e05, wu:fc10f02

Bezeichner auf Proteinebene für SUPT5H

  • DRB sensitivity-inducing factor 160 kDa subunit
  • DRB sensitivity-inducing factor large subunit
  • DSIF large subunit
  • DSIF p160
  • Tat-cotransactivator 1 protein
  • hSPT5
  • transcription elongation factor SPT5
  • transcription elongation factor Spt5
  • transcription elongation factor spt5
  • protein foggy
  • transcription elongation regulator foggy
  • CG7626-PA
  • Spt5-PA
  • Chromatin elongation factor SPT5
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