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The Arf6 is of particular interest,since it is believed to play a regulatory role in several cellular physiological functions, including cell-cell interactions(adhesiveness), motility, shape maintenance, and responses to environmental stimuli via cytoskeletal adaptations and vesicular trafficking.
computational study suggests that although curcumin to some extent binds with Tp receptor, yet the inhibition of Arf6GDP to Arf6GTP conversion appeared to be an important mechanism by which curcumin inhibits U46619-induced increase in PLD activity in PASMCs.
This study identifies a novel regulatory crosstalk between Ral (zeige rala Proteine) and Arf6 that controls Ral (zeige rala Proteine) function in cells.
ARHGAP24 (zeige ARHGAP24 Proteine) may regulate pseudopod formation downstream of activated ARF6 in MDA-MB-231 human breast carcinoma cells.
ARF6 was a downstream target of Kras/ERK (zeige EPHB2 Proteine) signaling pathway, and the strong correlation of expression between Kras and ARF6 in the TCGA dataset further confirmed this observation.
FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 signaling.
Macrophage tissue factor (zeige F3 Proteine) prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
Here the authors report that EspG interacts specifically with the small GTPases ARF6 and Rab35 (zeige RAB35 Proteine) during infection.
These results identify RalF as the first bacterial effector to directly activate Arf6, a process that initiates alterations in phosphoinositol metabolism critical for a lineage-specific Rickettsia entry mechanism.
Data suggest that activated ARF6 controls GNAQ (zeige GNAQ Proteine) and b-catenin signaling by regulating protein trafficking between intracellular compartments. Blocking ARF6 with a small-molecule inhibitor reduces uveal melanoma cell proliferation and tumorigenesis in a mouse model.
results indicated that Arf6 was involved in mouse oocyte meiosis through its functional roles in actin-mediated spindle movement and spindle organization.
The present study demonstrated that the Arf6-specific GAP ACAP3 plays a crucial role in neuronal migration through regulating morphological changes of neurons at intermediate zone of developing cerebral cortex.
Study demonstrates that Arf6 regulates neuronal migration in the intermediate zone through the FIP3 (zeige IKBKG Proteine)-dependent trafficking of endosomes containing N-cadherin (zeige CDH2 Proteine) during cortical layer formation.
The results show that ARNO (zeige CYTH2 Proteine) interaction with the RLIP76 (zeige RALBP1 Proteine) N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 (zeige RALBP1 Proteine) control of Rac (zeige AKT1 Proteine).
The present study provided evidence that BRAG2a is a novel component of the photoreceptor dystrophin (zeige DMD Proteine)-associated glycoprotein complex (DGC (zeige GGCX Proteine)), suggesting functional involvement of the BRAG2a-Arf6 pathway downstream of the DGC (zeige GGCX Proteine).
cycling between active and inactive forms of Arf6, which is precisely regulated by ACAP3 in concert with a guanine-nucleotide-exchange factor (zeige ARHGEF12 Proteine)(s), seems to be required for neurite outgrowth of hippocampal neurons
ARF6-dependent pathway is the predominant route responsible for the ABCA1 (zeige ABCA1 Proteine) internalization and degradation, whereas ARF6-independent endocytic pathways may contribute to ABCA1 (zeige ABCA1 Proteine) recycling and efflux of intracellular cholesterol.
These findings suggest that SDCCAG3 (zeige SDCCAG3 Proteine) might function in endosomal trafficking downstream of Arf6.
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
ADP-ribosylation factor 6
, ADP-ribosylation factor-like 6
, ADP-ribosylation factor-like protein 6