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We show that Arf6 functions in the adult nervous system to control ethanol-induced behavior.
Cindr-mediated regulation of Arf6 is a widely used mechanism in emerging epithelia.
ARF6 promotes rapid recycling of endosomal membrane stores during spermatocyte cytokinesis, which is critical for rapid cleavage furrow ingression.
ARHGAP24 (zeige ARHGAP24 Proteine) may regulate pseudopod formation downstream of activated ARF6 in MDA-MB-231 human breast carcinoma cells.
ARF6 was a downstream target of Kras/ERK (zeige EPHB2 Proteine) signaling pathway, and the strong correlation of expression between Kras and ARF6 in the TCGA dataset further confirmed this observation.
FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 signaling.
Macrophage tissue factor (zeige F3 Proteine) prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
Here the authors report that EspG interacts specifically with the small GTPases ARF6 and Rab35 (zeige RAB35 Proteine) during infection.
These results identify RalF as the first bacterial effector to directly activate Arf6, a process that initiates alterations in phosphoinositol metabolism critical for a lineage-specific Rickettsia entry mechanism.
Data suggest that activated ARF6 controls GNAQ (zeige GNAQ Proteine) and b-catenin signaling by regulating protein trafficking between intracellular compartments. Blocking ARF6 with a small-molecule inhibitor reduces uveal melanoma cell proliferation and tumorigenesis in a mouse model.
expression and activation of LHCGR (zeige LHCGR Proteine) and ARF6 are up-regulated in GC from PCOS women but the mechanism of agonist-induced LHCGR (zeige LHCGR Proteine) internalization is unaltered
The Squamous cell carcinoma of the tongue cell line SCC (zeige CYP11A1 Proteine)-9, which overexpress Arf6 and AMAP1 (zeige ASAP1 Proteine), also expressed EPB41L5 (zeige EPB41L5 Proteine) at high levels to promote invasiveness, whereas the weakly invasive SCC (zeige CYP11A1 Proteine)-25 cells did not express EPB41L5 (zeige EPB41L5 Proteine) at notable levels.
both Arf6 activation through GluN2B (zeige GRIN2B Proteine)-BRAG1 during early development and the transition from BRAG1- to BRAG2 (zeige IQSEC1 Proteine)-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
The present study demonstrated that the Arf6-specific GAP ACAP3 plays a crucial role in neuronal migration through regulating morphological changes of neurons at intermediate zone of developing cerebral cortex.
Study demonstrates that Arf6 regulates neuronal migration in the intermediate zone through the FIP3 (zeige IKBKG Proteine)-dependent trafficking of endosomes containing N-cadherin (zeige CDH2 Proteine) during cortical layer formation.
The results show that ARNO (zeige CYTH2 Proteine) interaction with the RLIP76 (zeige RALBP1 Proteine) N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 (zeige RALBP1 Proteine) control of Rac (zeige AKT1 Proteine).
The present study provided evidence that BRAG2a is a novel component of the photoreceptor dystrophin (zeige DMD Proteine)-associated glycoprotein complex (DGC (zeige GGCX Proteine)), suggesting functional involvement of the BRAG2a-Arf6 pathway downstream of the DGC (zeige GGCX Proteine).
cycling between active and inactive forms of Arf6, which is precisely regulated by ACAP3 in concert with a guanine-nucleotide-exchange factor (zeige ARHGEF12 Proteine)(s), seems to be required for neurite outgrowth of hippocampal neurons
ARF6-dependent pathway is the predominant route responsible for the ABCA1 (zeige ABCA1 Proteine) internalization and degradation, whereas ARF6-independent endocytic pathways may contribute to ABCA1 (zeige ABCA1 Proteine) recycling and efflux of intracellular cholesterol.
These findings suggest that SDCCAG3 (zeige SDCCAG3 Proteine) might function in endosomal trafficking downstream of Arf6.
Peripheral ARNO (zeige CYTH2 Proteine) promotes clathrin assembly through its GEF (zeige ARHGEF2 Proteine) activity for Arf6.
Pparg pathway acts on cephalic neural crest to direct adipocyte differentiation at the expense of osteoblast formation
PPAR (zeige PPARA Proteine) expression, the activity of its target gene AOX (zeige ACOX1 Proteine), and peroxisomal biogenesis are developmentally modulated in zebrafish
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
ADP ribosylation factor III
, ADP-ribosylation factor 6
, peroxisome proliferator-activated receptor gamma