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Human Polyclonal STS Primary Antibody für Func, ICC - ABIN1169071
Dashdorj, Jyothi, Lim, Jo, Nguyen, Ha, Yoon, Kim, Park, Murphy, Kim: Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines. in BMC medicine 2013
Show all 10 Pubmed References
Human Polyclonal STS Primary Antibody für IHC, ELISA - ABIN1850088
Xu, Wang, Wen, Sang, Wang, Zeng: Inhibition of NLRP3 inflammasome: a new protective mechanism of cinnamaldehyde in endotoxin poisoning of mice. in Immunopharmacology and immunotoxicology 2018
oligomerization of ASC creates a multitude of potential caspase-1 (zeige CASP1 Antikörper) activation sites, thus serving as a signal amplification mechanism for inflammasome-mediated cytokine production
Collectively, these results are consistent with a model whereby the type III secretion system apparatus of Pseudomonas aeruginosa activates the caspase-1 (zeige CASP1 Antikörper)-dependent inflammasome and caspase-3 (zeige CASP3 Antikörper)/7 through an ASC-dependent mechanism.
ASC specks released by microglia bind to amyloid-beta and increase amyloid-beta oligomer and aggregate formation, acting as an inflammation-driven cross-seed for amyloid-beta pathology
results suggest that although Pyk2 (zeige PTK2B Antikörper) and FAK (zeige PTK2 Antikörper) are involved in inflammasome activation, only Pyk2 (zeige PTK2B Antikörper) directly phosphorylates ASC and brings ASC into an oligomerization-competent state by allowing Tyr146 phosphorylation to participate ASC speck formation and subsequent NLRP3 (zeige NLRP3 Antikörper) inflammation.
Alendronate (ALN (zeige TTC21B Antikörper))-augmented IL-1beta (zeige IL1B Antikörper) production and cell death require Smad3 (zeige SMAD3 Antikörper) and ASC activation, and SIS3 and anti-ASC antibodies may serve as palliative agents for necrotizing inflammatory diseases caused by ALN (zeige TTC21B Antikörper)
These data provide evidence that the inflammasome components ASC, NLRP3 (zeige NLRP3 Antikörper) and AIM2 (zeige AIM2 Antikörper) play a role in regulating macrophage adhesion and activation in response to surface nanotopography and chemistry.
SGLT-2 (zeige SLC5A2 Antikörper) inhibition with dapagliflozin reduces the activation of the Nlrp3 (zeige NLRP3 Antikörper)/ASC inflammasome and attenuates the development of diabetic cardiomyopathy in mice with type 2 diabetes. Effects are augmentated of the by DPP4 (zeige DPP4 Antikörper) inhibitor Saxagliptin.
Elevations of CO2 cause oligomerization of the inflammasome components ASC, NLRP3 (zeige NLRP3 Antikörper), caspase 1 (zeige CASP1 Antikörper), thioredoxin interacting protein (zeige TXNIP Antikörper), and calreticulin (zeige CALR Antikörper) - a protein from endoplasmic reticulum, leading to IL-1beta (zeige IL1B Antikörper) synthesis. An increased production rate of MPs containing elevated amounts of IL-1beta (zeige IL1B Antikörper) persists for hours after short-term exposures to elevated CO2
Our cumulative findings indicate that ASC suppresses cancer metastasis and progression via the modulation of cytoskeletal remodeling and the Src (zeige SRC Antikörper)-caspase-8 (zeige CASP8 Antikörper) signaling pathway.
these findings suggest that p205 (zeige GNB2L1 Antikörper) controls expression of Asc mRNA to regulate inflammasome responses. These findings expand on our understanding of immune-regulatory roles for the PYHIN protein family.
STS is increased in preeclamptic placentas and maternal whole blood. Our data suggests that STS may affect sFlt1 (zeige FLT1 Antikörper) secretion by regulating sFlt1 (zeige FLT1 Antikörper)-i13 transcription, and not via alterations in syncytialisation.
This study reveals that STS is a key player of steroid biosynthesis regulating the availability of circulating cholesterol.
In contrast to the situation in boys with ADHD, in healthy men, the G-allele at rs17268988 of STS is associated with enhanced cognition.
miR (zeige MLXIP Antikörper)-661 overexpression sensitized tumors to TRAIL or STS induced apoptosis in a xenograft mouse model, and these effects were attenuated by co-expression of CYC1 (zeige CYC1 Antikörper).
Collectively, STS point mutations demonstrate restricted localization, causing efficient impairment of the corresponding enzyme activity, and are more unlikely to be responsible for the phenotypic heterogeneity in XLRI subjects
STS expression was not significantly associated with DFS (zeige FST Antikörper) and OS, despite positive STS expression in 27% of endometrial cancer patients. Therefore, the role of STS as a prognostic factor in patients with endometrial cancer remains unclear and requires further research.
The induced STS facilitates the conversion of inactive estrogen sulfates to active estrogens, which in return attenuates the NF-kappaB (zeige NFKB1 Antikörper)-mediated inflammation.
The antagonistic actions of glucocorticoids and NFkB on STS expression are similar to the regulation of inflammatory response proteins
Letter/Case Report: novel nonsense mutation in the STS gene in X-linked ichthyosis (zeige LBR Antikörper).
Data show that both estrogen sulfatase (STS) and estrogen sulfotransferase (EST) were highly expressed in the human umbilical vein endothelial cells (HUVECs).
The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI).
PYD and CARD domain-containing protein
, apoptosis-associated speck-like protein containing a CARD
, arylsulfatase C
, estrone sulfatase
, steryl-sulfate sulfohydrolase