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anti-Human CYP1B1 Antikörper:
anti-Mouse (Murine) CYP1B1 Antikörper:
anti-Rat (Rattus) CYP1B1 Antikörper:
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Human Polyclonal CYP1B1 Primary Antibody für IHC (p), WB - ABIN4301719
Meireles, Esteves, Hirata, Peri, Devarajan, Slifker, Mosier, Peng, Vadhanam, Hurst, Neves, Reis, Gairola, Gupta, Clapper: Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue. in Cancer prevention research (Philadelphia, Pa.) 2010
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Cow (Bovine) Polyclonal CYP1B1 Primary Antibody für WB - ABIN2784612
Wang, Hawkins, Miller: Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011
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Human Polyclonal CYP1B1 Primary Antibody für IHC, IHC (p) - ABIN4301717
Rodrigues, De Kock, Branson, Vinken, Meganathan, Chaudhari, Sachinidis, Govaere, Roskams, De Boe, Vanhaecke, Rogiers: Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals. in Stem cells and development 2013
In summary, these data expand the mutational and phenotypic spectra of CYP1B1 to include two novel alleles and additional developmental ocular phenotypes. The contribution of CYP1B1 to primary open angle glaucoma (POAG) is less clear, but loss-of-function variants in CYP1B1, especially c.1064_1076del, p.(Arg355Hisfs*69), may be associated with an increased risk for POAG.
In summary, a KLE cell-based model has been characterized to be suitable for identifying CYP1B1-targeted anticancer prodrugs and should be further developed and employed for screening chemical libraries.
AHR (zeige AHR Antikörper), CYP1A1 (zeige CYP1A1 Antikörper), CYP1A2 (zeige CYP1A2 Antikörper), or CYP1B1 variants associated with head-and-neck squamous cell carcinoma risk in smokers.
Our study identified nine different CYP1B1 mutations in 73.3% of the primary congenital glaucoma patients.
Our larger cohort suggests a tendency for girls with bi-allelic CYP1B1 mutations to have a more severe congenital phenotype as opposed to later-onset disease.
Increased expression of CYP1B1 is associated with ovarian/peritoneal endometriotic lesions.
CYP1B1 Leu432Val is associated with increased lung cancer susceptibility among Caucasians, and there is an interaction between CYP1B1 Leu432Val polymorphism and smoking, and Asn453- Ser (zeige SIGLEC1 Antikörper) and Ala119Ser may be not associated with lung cancer risk.
In this study, we identified 12 CYP1B1 mutations, 5 of which were novel. The frequency of CYP1B1 mutations in this cohort was comparable with other populations
CYP1B1 genotype activity and the microscopic and clinical phenotypes in human primary congenital glaucoma
Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, the study tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transplacental carcinogenesis. hCYP1B1 genotype did not impact lung tumor multiplicity, but tended to enhance incidence compared to Cyp1b1 wild-type mice (P = 0.07).
CYP1B1 contributed to the development of Ang II (zeige AGT Antikörper)-induced abdominal aortic aneurysm and associated pathogenic events in mice, likely by enhancing oxidative stress and associated signaling events
Miroestrol suppressed beta-naphthoflavone increases in CYP1B1.
Findings provide evidence that CYP1B1 is directly involved in the development of cardiac hypertrophy.
Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha (zeige HNF4A Antikörper) and PPARalpha (zeige PPARA Antikörper).
hypertension, and associated pathogenesis in ApoE (zeige APOE Antikörper)(-/-)/Cyp1b1(+/+) mice on an atherogenic diet are most likely dependent on CYP1B1-generated oxidative stress and increased plasma lipid levels independent of blood pressure and absorption of lipids.
Follicle stimulating hormone functions via p38 MAPK (zeige MAPK14 Antikörper)-induced dephosphorylation at Ser (zeige SIGLEC1 Antikörper)(727) of STAT1 (zeige STAT1 Antikörper) to downregulate Cyp1b1 expression and maintain the estradiol levels in mouse dominant follicles.
Cyp1b1 contributes to angiotensin II induced hypertension and its pathogenesis in male mice.
Suggest that Cyp1b1 plays a critical role in female mice in protecting against renal dysfunction and end-organ damage associated with ANG II (zeige AGT Antikörper)-induced hypertension.
Data indicaate that adduct formation in cytochrome P450 (zeige CYP Antikörper) Cyp1b1 knockout mice was significantly reduced compared to wild-type mice receiving dibenzo[def,p]chrysene (DBC).
CYP1B1 knockdown studies show CYP1B1 is not a significant factor in causing synergistic toxicity of PAHs, nor, in contrast to CYP1A, in providing protection
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma\; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
cytochrome P450 1B1
, cytochrome P450, family 1, subfamily B, polypeptide 1
, aryl hydrocarbon hydroxylase
, cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, xenobiotic monooxygenase
, benz[a]anthracene inducible
, cytochrome P450, 1b1, benz[a]anthracene inducible
, cytochrome P450CMEF
, cytochrome P450EF
, cytochrome P450, subfamily 1B, polypeptide 1
, cytochrome P450RAP
, cytochrome P4501B