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Human Monoclonal AKR1C2 Primary Antibody für ELISA, WB - ABIN514927
Takahashi, Bains, Pfeifer, Grigliatti, Reid, Riggs: Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro. in Drug metabolism and disposition: the biological fate of chemicals 2008
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Human Polyclonal AKR1C2 Primary Antibody für WB - ABIN514925
Ebert, Kisiela, Wsól, Maser: Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. in Chemico-biological interactions 2011
Human Polyclonal AKR1C2 Primary Antibody für ELISA, WB - ABIN560582
Su, Liao, Huang, Chu, Lin, Chang: Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis. in Toxicology 2008
Curcumin treatments considerably increased the expression of AKR1C2 in prostate cancer cell lines.
Data show that increased levels of AKR1C1 (zeige DDH Antikörper)/C2 enhanced the sensitivity of esophageal squamous cell carcinoma (ESCC) cells to ethyl-3,4-dihydroxybenzoate (EDHB).
The reduction of DHT obese homozygotic twins could be linked to its increased degradation by AKR1C2 and HSD11B1 (zeige HSD11B1 Antikörper), and increased estrogen levels could be linked to increased adiposity-related expression of aromatase (zeige CYP19A1 Antikörper) in adipose tissue.
the present study suggests that AKR1C1 (zeige DDH Antikörper), AKR1C2, AKR1C3 (zeige AKR1C3 Antikörper), and AKR1C4 (zeige AKR1C4 Antikörper) are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.
We identified two powerful genes in the liver cancer metastasis process, AEG-1 (zeige MTDH Antikörper) and AKR1C2.
Identify two novel factors, AKR1C2 (positive factor) and NF1 (zeige NF1 Antikörper) (negative factor), as the AEG-1 (zeige MTDH Antikörper) downstream players in the process of metastasis in liver cancer.
The endogenous HMOX1 (zeige HMOX1 Antikörper) gene but not the AKR1C2 gene is strongly repressed by Bach1 (zeige BACH1 Antikörper) in HaCaT keratinocytes.
In model cell lines of endometrial cancer, AKR1C2 and SRD5A1 (zeige SRD5A1 Antikörper) have crucial roles in progesterone metabolism.
Significantly higher levels of SRD5A1 (zeige SRD5A1 Antikörper), AKR1C2, AKR1C3 (zeige AKR1C3 Antikörper), and HSD17B10 (zeige HSD17B10 Antikörper) mRNA were however found in bone metastases than in non-malignant and/or malignant prostate tissue
The V54L mutation significantly decreases the 3alpha-hydroxysteroid dehydrogenase activity of DDH2 for the reduction of dihydrotestosterone.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.
, aldo-keto reductase family 1 member C2
, chlordecone reductase homolog HAKRD
, dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III
, pseudo-chlordecone reductase
, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
, type II dihydrodiol dehydrogenase
, 17-alpha-hydroxysteroid dehydrogenase
, 3(or 17)-alpha-hydroxysteroid dehydrogenase
, 3-alpha-hydroxysteroid dehydrogenase
, aldo-keto reductase family 1 member C21
, aldo-keto reductase family 1, member C21