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anti-Human VANGL2 Antikörper:
anti-Mouse (Murine) VANGL2 Antikörper:
anti-Rat (Rattus) VANGL2 Antikörper:
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Human Polyclonal VANGL2 Primary Antibody für ELISA, WB - ABIN252943
Kibar, Vogan, Groulx, Justice, Underhill, Gros: Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. in Nature genetics 2001
VANGL2 interacts with Integrin alphaVbeta3 to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.
Our experimental data demonstrate that high expression of Prickle1 (zeige PRICKLE1 Antikörper) and Vangl2 reduce the growth of neuroblastoma (zeige ARHGEF16 Antikörper) cells and indicate different roles of PCP (zeige PRCP Antikörper) proteins in tumorigenic cells compared to normal cells.
VANGL2 is overexpressed in basal breast cancers. It is involved in the proliferative signal cascade of the VANGL2-SQSTM1 (zeige SQSTM1 Antikörper)-JNK (zeige MAPK8 Antikörper) pathway.
Propose that Arfrp1 (zeige ARFRP1 Antikörper) exposes a binding site on AP-1 (zeige FOSB Antikörper) that recognizes the Vangl2 sorting motif for capture into a transport vesicle destined for the proximal surface of a polarized epithelial cell.
The aberrant VANGL2 promoter methylation and the decreased gene expression is associated with Tetralogy of Fallot.
Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT (zeige WNT2 Antikörper)/planar cell polarity pathway.
Van-Gogh-like 2 is frequently methylated in MSI (zeige MSI1 Antikörper)-CRCs with BRAF (zeige BRAF Antikörper) mutation and may act as a tumour suppressor gene, counteracting WNT (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling.
these findings strongly implicate VANGL2 in the genetic causation of spinal NTDs in a subset of patients and provide additional evidence for a pathogenic role of PCP (zeige PRCP Antikörper) signaling in these malformations.
Loss of membrane targeting of Vangl1 (zeige Vangl1 Antikörper) and Vangl2 proteins causes neural tube defects.
The planar cell polarity genes Celsr1 (zeige CELSR1 Antikörper) and Vangl2 are required for normal lung branching morphogenesis.
a novel chemically induced mutant allele at Vangl2 called Curly Bob that causes a missense mutation p.Ile268Asn (I268N) in the Vangl2 protein, is reported.
disruption of Vangl2-dependent planar-polarised processes in the posterior neuropore neuroepithelium and surface ectoderm preclude zippering point biomechanical accommodation associated with Closure 5 formation at the completion of posterior neuropore closure.
The Vangl2 phosphorylation, which was previously identified to be induced by Wnt5a (zeige WNT5A Antikörper) signaling, is required for Vangl2 functions in mammalian Planar cell polarity (PCP (zeige BMP1 Antikörper)) in multiple tissues.
type II spiral ganglion neurons make a distinctive 90 degrees turn towards the cochlear base to synapse with 10-15 outer hair cells. this axon turning event requires planar cell polarity signaling and is disrupted in Vangl2 and Celsr1 (zeige CELSR1 Antikörper) knockout mice and VANGL2 acts non-autonomously from the cochlea to direct turning.
In Pax2-Cre; V1V2 Conditional knockout mice, the loss of both VANGL proteins significantly disrupts planar polarity throughout the utricular maculae
The Celsr3 (zeige CELSR3 Antikörper)-mediated signaling pathway responds to the inhibitory function of Wnt5a (zeige WNT5A Antikörper) in glutamatergic synapse formation. We also revealed the opposing roles of Wnt (zeige WNT2 Antikörper)-regulated planar cell polarity components, Celsr3 (zeige CELSR3 Antikörper) and Vangl2, in glutamatergic synapse formation.
Exogenously introduced expression of green fluorescent protein (GFP)-tagged core PCP (zeige BMP1 Antikörper) factors by electroporation revealed that Vangl1 (zeige Vangl1 Antikörper), Vangl2 and Prickle2 (zeige PRICKLE2 Antikörper) are localized on the ovarian side of the cell periphery in the oviduct.Our data collectively suggest that the mechanism for maintenance of Vangl2 asymmetry in mature mouse oviduct is different from the microtubule dependent polarized transport model
heterozygous Looptail (Lp) mice, in which a single copy of the core PCP (zeige BMP1 Antikörper) gene, Vangl2, is disrupted are viable but display severe airspace enlargement and impaired adult lung function.
interacts with Celsr1 (zeige CELSR1 Antikörper) in ureteric tree growth
Vangl2 is expressed in the inner dental epithelium (IDE (zeige IDE Antikörper)) and in the secondary enamel knots (SEKs) of bell stage tooth germs.
Results demonstrate that anterior guidance decisions by commissural primary ascending (CoPA (zeige COPA Antikörper)) axons are dependent on the function of planar cell polarity genes Fzd3a, Vangl2 and Scribble (zeige SCRIB Antikörper) both prior to and after midline crossing; experiments establish CoPA (zeige COPA Antikörper) axons as a model system to investigate the mechanism of planar cell polarity signaling in commissural axon guidance.
dynamic Vangl2 intracellular distribution is coordinated with and necessary for the changes in convergence and extension cell behaviors during gastrulation
we found that the critical period for Vangl2 function coincides with the initial stages of FBM neuron migration out of rhombomere 4.
Vangl2 regulates FBM neuron migration by acting in floor plate cells, independently of cilia function
VANGL2 regulates the endocytosis and cell-surface availability of MMP14 in a manner that is dependent on focal adhesion kinase.
Vangl2(R259L) behaved like the wild-type allele in overexpression and morpholino knockdown/rescue assays in zebrafish embryos.
Rack1 (zeige GNB2L1 Antikörper) has a dominant-negative effect on Vangl2 localization and gastrulation.
data suggest that bbs8 (zeige TTC8 Antikörper) and vangl2 act synergistically on cell polarization to establish and maintain the appropriate length and number of cilia in the Kupffer's vesicle and thereby facilitate correct LR asymmetry
Vangl2 is required for asymmetric localization and posterior tilting of primary motile cilia at the apical membrane of epithelial cells.
show that anterior hindbrain (r2/r3) motor neuron migration appears to be independent of vangl2 and pk1b functions, and suggest that multiple mechanisms regulate motor neuron migration along the anterior-posterior axis of the zebrafish hindbrain
Rab11 (zeige RAB11A Antikörper) and the associated motor protein (zeige MYO7A Antikörper) Myosin V (zeige MYO5A Antikörper) play essential roles in both endogenous and ectopic apical constriction, and might be involved in Vangl2 trafficking to the cell surface.
The interaction and interdependence of Vangl2, VAMP1 (zeige VAMP1 Antikörper), aPKC and the stable microtubule cytoskeleton in the oocyte, shows that maternal Vangl2 and aPKC are required for specific oocyte asymmetries and vertebrate embryonic patterning.
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate.
, protein strabismus
, van Gogh-like protein 2
, vang-like 2 (van gogh, Drosophila)
, vang-like protein 2
, loop-tail protein 1 homolog
, loop-tail-associated protein
, strabismus 1
, loop tail associated protein
, loop-tail protein 1
, vang (van gogh)-like 2
, protein trilobite
, protein strabismus-B
, van Gogh-like protein 2-B
, vang-like 2 (van gogh, Drosophila) b
, vang-like 2 b
, vang-like protein 2-B
, vang-like 2