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Tal1 plays an essential role in regulating neurotransmitter phenotype in the developing thalamic nuclei.
Genome-wide analysis indicated that LMO2 (zeige LMO2 Proteine) is required at the hemangioblast stage to position the TAL1/LMO2 (zeige LMO2 Proteine)/LDB1 (zeige LDB1 Proteine) complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
TAL1 and GATA1 (zeige GATA1 Proteine) form a precisely organized complex at a compound motif consisting of a TG 7 or 8 bp upstream of a WGATAA motif across thousands of genomic locations
SCL-LMO1 (zeige LMO1 Proteine) upregulated a stem cell gene signature in DN3 thymocytes.
TAL1 binds specifically to many genomic locations in multilineage precursor and erythroid progenitor cells, before GATA1 (zeige GATA1 Proteine) is produced abundantly.
Ectopic Runx1 (zeige RUNX1 Proteine) expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
Tal1 has a role in severe renal disease and patchy alopecia in Hairpatches (Hpt) mice
Only Scl but not Map17 (zeige PDZK1IP1 Proteine) could rescue the Scl(Delta40/Delta40) ES phenotype.
Scl overexpression is sufficient to rescue the developmental defects caused by blocking the Hh and Notch (zeige NOTCH1 Proteine) pathways during the embryonic endothelial-to-hematopoietic transition.
a novel role for GATA-4 (zeige GATA4 Proteine) and TAL1 to affect skeletal myogenic differentiation and EPO (zeige EPO Proteine) response via cross-talk with Sirt1 (zeige SIRT1 Proteine).
HOPX (zeige HOPX Proteine) is functionally regulated by SCL (zeige KRT7 Proteine) in hematoendothelial differentiation of mesoderm progenitor cells.
NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR
mutations of SF3B1 (zeige SF3B2 Proteine) may block erythropoiesis via dysregulation of alternative RNA splicing of transcription factor TAL1
a novel role of FOXP3 (zeige FOXP3 Proteine) as a tumor suppressor in T-ALL through modulation of TAL1 transcriptional activity.
Review emphasizes recent findings that shed light into the intricacies of TAL1 (epi (zeige TFPI Proteine))genetic regulation and the transcription network orchestrated by this major T-cell oncogene (zeige RAB1A Proteine).[reiew]
Deletions of TAL1 is associated with acute T-lymphoblastic leukemia.
SCL/TAL1 (stem cell leukemia/T-cell acute lymphoblastic leukemia [T-ALL] 1) is an essential transcription factor in normal and malignant hematopoiesis.
Upregulation of TAL1 is associated with T-cell acute lymphoblastic leukemia.
Concurrent exogenous expression of three transcription factors, GATA1 (zeige GATA1 Proteine), FLI1 (zeige FLI1 Proteine) and TAL1, enables large-scale production of megakaryocytes from human pluripotent stem cells.
analysis of a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter
The latter data suggest that Stil play a role in retina cell proliferation through the Shh (zeige SHH Proteine) signal transduction pathway.
Tal1 has distinct roles in regulating the formation of endocardial intercellular junctions.
Data suggest that a defined hemogenic endothelial population preset by scl-beta supports the deterministic emergence of HSCs, and unravel the cellular mechanisms by which scl isoforms regulate HSC (zeige FUT1 Proteine) development.
Our studies establish a new connection between RA and scl during development that may participate in stem cell self-renewal and hematopoietic differentiation
Ets1-related protein (zeige ETV2 Proteine) plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts.
in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2 (zeige LMO2 Proteine)-induced haemangioblasts differentiate into endothelial cells
Zebrafish scl has a role in hematopoietic and endothelial development, downstream of hemangioblast development.
scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium
Scl participates in multiple processes requiring different levels and functions
While scl-alpha and -beta are redundant for the initiation of primitive hematopoiesis, these two isoforms exert distinct functions in the regulation of primitive erythroid differentiation and definitive hematopoietic stem cell specification.
Transcription factor that acts synergistically with lmo2 and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate.
T-cell acute lymphocytic leukemia 1
, T-cell acute lymphocytic leukemia protein 1 homolog
, stem cell protein
, T-cell acute lymphocytic leukemia protein 1
, T-cell leukemia/lymphoma protein 5
, class A basic helix-loop-helix protein 17
, tal-1 product
, stem cell leukaemia
, stem cell leukemia protein SCL
, Avian SCL
, stem-cell leukemia hematopoietic transcription factor
, transcription factor