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The analysis points to a critical role for Hoxa9 (zeige HOXA9 Proteine) and PU.1 in distal regulation of c-myb (zeige MYB Proteine) expression in murine myeloid cells during iL-6 (zeige IL6 Proteine)-induced cell differentiation.
These studies reveal an important role for PU.1 in the regulation of Igkappa transcription and rearrangement and a requirement for PU.1 and Spi-B (zeige SPIB Proteine) in B cell development.
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in a model of beta-thalassemia
Moreover, the expression of a cell proliferation marker Ki67 (zeige MKI67 Proteine) was significantly decreased in tumors from the mice not taking doxycycline, compared with that of tumors from the mice continuously taking doxycycline. The present data strongly suggest that PU.1 functions as a tumor suppressor of myeloma cells in vivo.
the affinities of two sequence-divergent ETS (zeige ETS1 Proteine) homologs, PU.1 and Ets-1 (zeige ETS1 Proteine), to DNA sites harboring a hemi- and fully methylated CpG dinucleotide, were measured.
this study shows that PU.1 functions as a positive regulator of CD11c (zeige ITGAX Proteine) gene expression by directly binding to the Itgax (zeige ITGAX Proteine) promoter and through transactivation of the Irf4 (zeige IRF4 Proteine) gene
Here we demonstrate that the transcription factors SPI1 (PU.1) and HOXC13 synergistically regulate Zfp521 expression, and identify the regions of the Zfp521 promoter required for this transcriptional activity. We also show that SPI1 and HOXC13 activate Zfp521 in a dose-dependent manner.
findings suggest that Gata1 (zeige GATA1 Proteine) & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
involved in osteoclast development by transactivating NFATc1 (zeige NFATC1 Proteine) expression via direct binding to the NFATc1 (zeige NFATC1 Proteine) promoter
GATA1 (zeige GATA1 Proteine) and PU.1 bind in vitro and in vivo the proximal promoter region of the RPS19 (zeige RPS19 Proteine) gene which is frequently mutated in Diamond-Blackfan Anemia.
PU.1 and IL-9 (zeige IL9 Proteine) may play a role in AD pathogenesis and relate to disease severity and clinical eruption types.
PU.1-induced apoptosis in myeloma cells is associated with IRF4 (zeige IRF4 Proteine) downregulation and subsequent IRF7 (zeige IRF7 Proteine) upregulation.
Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (zeige CD68 Proteine) (6 of 7 cases), CD163 (zeige CD163 Proteine) (5 of 5 cases), and PU.1 (3 of 4 cases).
findings highlight a unique role of SPI1 fusions in high-risk pediatric T cell acute lymphoblastic leukemia
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in beta-thalassemia
RUNX1 (zeige RUNX1 Proteine) overexpression induced partial DNA demethylation at SPI1 proximal promoter.
This study demonstrated the novel role of PU.1 in the immune response to A. fumigatus through upregulation of Dectin-1 expression and its translocation to the nucleus in A. fumigatus-stimulated THP-1 cells.
PU.1 is an important modulator of VDR signaling in monocytes.
Forced FOG1 (zeige ZFPM1 Proteine) protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 (zeige SLC4A1 Proteine) protein, but repressed that of transcription factor PU.1.
The vertical and paralleled Pu.1/Spi-b (zeige SPIB Proteine) regulatory networks control the development of rostral blood island and ventral wall of dorsal aorta-borne macrophages by regulating Irf8 (zeige IRF8 Proteine).
eaf1 (zeige EAF1 Proteine) has a role in suppressing foxo3b expression to modulate transcriptional activity of gata1 (zeige GATA1 Proteine) and spi1 in primitive hematopoiesis
Our results indicate that Kzp (zeige ANPEP Proteine) is a critical transcriptional factor for the expression of gata2 and pu.1 to modulate primitive hematopoiesis.
Runx1 (zeige RUNX1 Proteine) is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
The authors show that tif1gamma (zeige TRIM33 Proteine) modulates the erythroid versus myeloid fate outcomes from HSCs by differentially controlling the levels of gata1 (zeige GATA1 Proteine) and pu.1.
found a gene group downregulated on spi1 knockdown,containing all 5 previously identified Spi1-dependent genes as well as a large set of novel immune-related genes
In zebrafish, spi1 marks a rostral population of LPM cells committed to a myeloid fate anatomically separated from and developmentally independent of erythroid commitment in the caudal LPM.
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
, contrapsin-like protease inhibitor 3
, contrapsin-like protease inhibitor-related protein
, liver regeneration protein lrryan
, serine protease inhibitor 1
, serine protease inhibitor 2.1
, serine protease inhibitor 2a
, serine protease inhibitor A3L
, serpin A3L
, 31 kDa transforming protein
, 31 kDa-transforming protein
, SPI-1 proto-oncogene
, hematopoietic transcription factor PU.1
, spleen focus forming virus (SFFV) proviral integration oncogene spi1
, transcription factor PU.1
, SFFV proviral integration 1 protein
, SFFV proviral integration 1
, spleen focus forming virus proviral integration oncogene spi1
, Spi-1/PU.1 transcription factor
, transcription factor spi1