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PU.1 binds to OX40L promoter in dendritic cells (zeige ETS1 Proteine).
These results bring indirect evidence that leukemia develops from cells which have bypassed Spi1-induced senescence. Overall, our results reveal senescence as a Spi1-induced anti-proliferative mechanism that may be a safeguard against the development of acute myeloid leukemia (zeige BCL11A Proteine).
In contrast, expression of Spi1/PU.1 in a Fli1 (zeige FLI1 Proteine) producing erythroleukemia cell line in which fli1 (zeige FLI1 Proteine) is activated, resulted in increased proliferation through activation of growth promoting proteins MAPK (zeige MAPK1 Proteine), AKT (zeige AKT1 Proteine), cMYC (zeige MYC Proteine) and JAK2 (zeige JAK2 Proteine)
Data show that protein phosphatase-1 (zeige PPP1CB Proteine) alpha (PP1alpha (zeige PPP1CA Proteine)) is required to maintain checkpoint kinase 1 (CHK1 (zeige CHEK1 Proteine)) in a dephosphorylated state and for the accelerated replication fork progression in Spi1/PU.1 transcription factor-overexpressing cells.
PU.1 supports TRAIL-induced cell death by inhibiting RelA (zeige NFkBP65 Proteine)-mediated cell survival and inducing DR5 (zeige TNFRSF10B Proteine) expression.
PU.1 and IL-9 (zeige IL9 Proteine) may play a role in AD pathogenesis and relate to disease severity and clinical eruption types.
PU.1-induced apoptosis in myeloma cells is associated with IRF4 (zeige IRF4 Proteine) downregulation and subsequent IRF7 (zeige IRF7 Proteine) upregulation.
Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (zeige CD68 Proteine) (6 of 7 cases), CD163 (zeige CD163 Proteine) (5 of 5 cases), and PU.1 (3 of 4 cases).
findings highlight a unique role of SPI1 fusions in high-risk pediatric T cell acute lymphoblastic leukemia
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in beta-thalassemia
PU.1 can bind directly to the most-proximal Ets (zeige ETS1 Proteine) motif, which is essential for the transcriptional function of the mouse OX40L (zeige TNFSF4 Proteine) promoter in dendritic cells.
PU.1 suppresses Sirt1 (zeige SIRT1 Proteine) translation via transcriptional promotion of miR (zeige MLXIP Proteine)-34a/-29c.
The analysis points to a critical role for Hoxa9 (zeige HOXA9 Proteine) and PU.1 in distal regulation of c-myb (zeige MYB Proteine) expression in murine myeloid cells during iL-6 (zeige IL6 Proteine)-induced cell differentiation.
These studies reveal an important role for PU.1 in the regulation of Igkappa transcription and rearrangement and a requirement for PU.1 and Spi-B (zeige SPIB Proteine) in B cell development.
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in a model of beta-thalassemia
Moreover, the expression of a cell proliferation marker Ki67 (zeige MKI67 Proteine) was significantly decreased in tumors from the mice not taking doxycycline, compared with that of tumors from the mice continuously taking doxycycline. The present data strongly suggest that PU.1 functions as a tumor suppressor of myeloma cells in vivo.
the affinities of two sequence-divergent ETS (zeige ETS1 Proteine) homologs, PU.1 and Ets-1 (zeige ETS1 Proteine), to DNA sites harboring a hemi- and fully methylated CpG dinucleotide, were measured.
this study shows that PU.1 functions as a positive regulator of CD11c (zeige ITGAX Proteine) gene expression by directly binding to the Itgax (zeige ITGAX Proteine) promoter and through transactivation of the Irf4 (zeige IRF4 Proteine) gene
Here we demonstrate that the transcription factors SPI1 (PU.1) and HOXC13 synergistically regulate Zfp521 expression, and identify the regions of the Zfp521 promoter required for this transcriptional activity. We also show that SPI1 and HOXC13 activate Zfp521 in a dose-dependent manner.
findings suggest that Gata1 (zeige GATA1 Proteine) & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
Data show that Spi1 is a downstream target of histone demethylase Jmjd3 (Jmjd3) during myelopoiesis.
The vertical and paralleled Pu.1/Spi-b (zeige SPIB Proteine) regulatory networks control the development of rostral blood island and ventral wall of dorsal aorta-borne macrophages by regulating Irf8 (zeige IRF8 Proteine).
eaf1 (zeige EAF1 Proteine) has a role in suppressing foxo3b expression to modulate transcriptional activity of gata1 (zeige GATA1 Proteine) and spi1 in primitive hematopoiesis
Our results indicate that Kzp (zeige ANPEP Proteine) is a critical transcriptional factor for the expression of gata2 and pu.1 to modulate primitive hematopoiesis.
Runx1 (zeige RUNX1 Proteine) is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
The authors show that tif1gamma (zeige TRIM33 Proteine) modulates the erythroid versus myeloid fate outcomes from HSCs by differentially controlling the levels of gata1 (zeige GATA1 Proteine) and pu.1.
found a gene group downregulated on spi1 knockdown,containing all 5 previously identified Spi1-dependent genes as well as a large set of novel immune-related genes
In zebrafish, spi1 marks a rostral population of LPM cells committed to a myeloid fate anatomically separated from and developmentally independent of erythroid commitment in the caudal LPM.
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
31 kDa transforming protein
, 31 kDa-transforming protein
, SPI-1 proto-oncogene
, hematopoietic transcription factor PU.1
, spleen focus forming virus (SFFV) proviral integration oncogene spi1
, transcription factor PU.1
, SFFV proviral integration 1 protein
, SFFV proviral integration 1
, spleen focus forming virus proviral integration oncogene spi1
, transcription factor spi1
, Spi-1/PU.1 transcription factor
, LOW QUALITY PROTEIN: transcription factor PU.1
, spleen focus forming virus (SFFV) proviral integration oncogene