Prospero Homeobox 1 Proteine (PROX1)

Human Prospero Homeobox 1 (PROX1) Interaktionspartner

1. Prox1 is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1 (zeige NOTCH1 Proteine).

2. PROX1 is a new prognostic biomarker for 1p19q non-codeleted high-grade astrocytomas that have progressed from pre-existing low-grade tumors and harbor IDH mutations.

3. ERbeta in both normal and cancerous colon epithelial cells upregulates miRNA-205, which subsequently reduces PROX1 through direct interaction with its 3'UTR

4. The aim of this study was to examine the association between HHEX (zeige HHEX Proteine) (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .Despite these associations, PROX1 gene variants were not previously examined in women with GDM; however, our results suggest a lack of such an association.

5. PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.

6. study achieved a long-lasting expression of Prox1 in lymphatic endothelial-like cells, and it provided a potentially useful approach for developing novel therapies for limb lymphedema and lymphatic system-related diseases

7. In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis.

8. High PROX1 and beta-catenin (zeige CTNNB1 Proteine) expression were independent factors for better prognosis in pancreatic ductal adenocarcinoma.

9. Data suggest that DBC1 has a dual function in regulating beta-catenin (zeige CTNNB1 Proteine)-PROX1 signaling axis: as a coactivator for both beta-catenin (zeige CTNNB1 Proteine) and PROX1.

10. PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity.

Mouse (Murine) Prospero Homeobox 1 (PROX1) Interaktionspartner

1. Prox1 (zeige C16orf35 Proteine) is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1 (zeige NOTCH1 Proteine).

2. the embryonic dermal blood capillary plexus constitutes a local source of embryonic lymphatic endothelial cells that contributes to the formation of the dermal lymphatic vascular network. Rare PROX1 (zeige C16orf35 Proteine)-positive endothelial cells exit the capillary plexus in a Ccbe1 (zeige CCBE1 Proteine)-dependent manner to establish discrete embryonic lymphatic endothelial cell clusters.

3. PROX1 (zeige C16orf35 Proteine) controls expression of genes regulating lipid homeostasis.HDAC3 interacts with PROX1 (zeige C16orf35 Proteine).

4. the neurogenic and oligodendrogliogenic lineages in the two adult neurogenic niches exhibit a distinct requirement for Prox1 (zeige C16orf35 Proteine).

5. PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.

6. Our study demonstrates that Prox1 (zeige C16orf35 Proteine)-GFP/Flk1 (zeige KDR Proteine)::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses

7. Prox1 (zeige C16orf35 Proteine) was first expressed in all developing neurons, followed by a decrease in type II primary auditory neurons as they matured.

8. Data indicate that prospero-related homeobox 1 (Prox1) has a role in regulating energy homeostasis in hepatocytes.

9. These results are the first demonstration that Prox1 (zeige C16orf35 Proteine) activity protects pancreatic cells from acute tissue damage and early neoplastic transformation. Additional data in our study indicate that this novel role of Prox1 (zeige C16orf35 Proteine) involves suppression of pathways associated with inflammatory responses and cell invasiveness.

10. the data show that Prox1 (zeige C16orf35 Proteine) regulates proliferation and differentiation of the oligodendrocyte cell lineage, and is a relevant component of the endogenous regenerative response to Central nervous system injury.

Zebrafish Prospero Homeobox 1 (PROX1) Interaktionspartner

1. using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages

2. Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.

3. Prox1 functions as a tissue-specific coregulator of Ff1b

4. Our findings indicate that prox1 activity is crucial for the proper development of the otp1 (zeige OTOP1 Proteine)-positive hypothalamic neuronal precursors to their terminal CA phenotype