Prospero Homeobox 1 Proteine (PROX1)

Human Prospero Homeobox 1 (PROX1) Interaktionspartner

1. Prox1 protein expression was significantly higher in Crohn's Disease than in normal tissues. Decreased expression of Prox1 is associated with Postoperative Recurrence in Crohn's Disease. Prox1 expression could be useful as a protective factor against recurrence in Crohn's Disease patients.

2. PROX1 expression was detected in gastric cancer tissues at various levels. PROX1 expression levels were positively correlated with cancer stage, N factor, lymphatic vascular invasion, and vascular invasion in patients with gastric cancer.

3. The present data demonstrate that the endothelial-specific and lymph endothelial-specific transcription factors SOX18 and PROX1 contribute to lymph endothelial cells retraction.

4. Prox1 is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1.

5. PROX1 is a new prognostic biomarker for 1p19q non-codeleted high-grade astrocytomas that have progressed from pre-existing low-grade tumors and harbor IDH mutations.

6. ERbeta in both normal and cancerous colon epithelial cells upregulates miRNA-205, which subsequently reduces PROX1 through direct interaction with its 3'UTR

7. The aim of this study was to examine the association between HHEX (rs5015480) and PROX1 (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .Despite these associations, PROX1 gene variants were not previously examined in women with GDM; however, our results suggest a lack of such an association.

8. PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.

9. crucial promoter of hepatocellular carcinoma angiogenesis

10. study achieved a long-lasting expression of Prox1 in lymphatic endothelial-like cells, and it provided a potentially useful approach for developing novel therapies for limb lymphedema and lymphatic system-related diseases

11. In gastric cancer, high cytoplasmic PROX1 expression is an independent marker of better prognosis.

12. High PROX1 and beta-catenin expression were independent factors for better prognosis in pancreatic ductal adenocarcinoma.

13. Data suggest that DBC1 has a dual function in regulating beta-catenin-PROX1 signaling axis: as a coactivator for both beta-catenin and PROX1.

14. PROX1 gene is a strong candidate of early onset of diabetes with variations depending on ethnicity.

15. We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant

16. PROX1 serves an oncogenic role in glioblastoma multiforme and promotes cell proliferation and invasiveness potentially via activation of the NFkappa B signaling pathway.

17. High PROX1 expression is associated with gastric cancer.

18. High PROX1 expression is associated with Esophageal Squamous Cell Carcinoma.

19. Reduced expression of Prox1 is beneficial for the expansion and maturation of beta-cells.

20. PROX1 is an important regulator of endocrine secretory granule formation in medullary thyroid cancer cells.

Mouse (Murine) Prospero Homeobox 1 (PROX1) Interaktionspartner

1. Prox1 was transiently expressed in the presumptive hair cells of the vestibular and auditory sensory organs.

2. Findings indicate that prospero homeobox 1 (Prox1) regulated the differentiation of oligodendrocyte precursor cells via the regulation of phorbol-12-myristate-13-acetate-induced protein 1 (NOXA).

3. Prox1 is a critical transcription factor for the differentiation of myoblasts via bi-directional crosstalk with Notch1.

4. the embryonic dermal blood capillary plexus constitutes a local source of embryonic lymphatic endothelial cells that contributes to the formation of the dermal lymphatic vascular network. Rare PROX1-positive endothelial cells exit the capillary plexus in a Ccbe1-dependent manner to establish discrete embryonic lymphatic endothelial cell clusters.

5. PROX1 controls expression of genes regulating lipid homeostasis.HDAC3 interacts with PROX1.

6. the neurogenic and oligodendrogliogenic lineages in the two adult neurogenic niches exhibit a distinct requirement for Prox1.

7. PROX1 overexpression in DAB2IP-deficient prostate cancer cells could enhance the accumulation of HIF1alpha protein by inhibiting ubiquitin pathway and then consequently induce an epithelial-mesenchymal transition response.

8. crucial promoter of hepatocellular carcinoma angiogenesis

9. Our study demonstrates that Prox1-GFP/Flk1::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses

10. Prox1 was first expressed in all developing neurons, followed by a decrease in type II primary auditory neurons as they matured.

11. Data indicate that prospero-related homeobox 1 (Prox1) has a role in regulating energy homeostasis in hepatocytes.

12. These results are the first demonstration that Prox1 activity protects pancreatic cells from acute tissue damage and early neoplastic transformation. Additional data in our study indicate that this novel role of Prox1 involves suppression of pathways associated with inflammatory responses and cell invasiveness.

13. the data show that Prox1 regulates proliferation and differentiation of the oligodendrocyte cell lineage, and is a relevant component of the endogenous regenerative response to Central nervous system injury.

14. Prox1 upregulation reduces proliferation, impairs maturation, and enables apoptosis in postnatal beta-cells. Prox1 overexpression causes MafA deficiency in beta-cells.

15. The PROX1-mediated repression is weakened or lost, thereby facilitating the induction of Reverse cholesterol transport genes and diminishing the progression of atherosclerosis

16. suggest that Prox1 appears to be a critical stage specific regulator of specifying ascending thin limb cell fate and that its expression is regulated by osmolality

17. we demonstrate that Prox1 and Asap1 behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.

18. Prox1 is made in postmitotic CGE-derived cortical interneuron precursors. It is differentially required during embryonic and postnatal stages for migration, differentiation, circuit integration, and maintenance programs in subtypes of these interneurons.

19. Sox2 was not restricted to developing taste bud cells expressing Prox1 during circumvallate development.

20. Expression of fluorescent Prox-1 allows functional characterization of Schlemm's canal.

Zebrafish Prospero Homeobox 1 (PROX1) Interaktionspartner

1. Overall, the data show that HHEX controls blood vessel and lymphatic vessel formation by regulating the VEGFC/FLT4/PROX1 signaling axis.

2. using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages

3. Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.

4. Prox1 functions as a tissue-specific coregulator of Ff1b

5. Our findings indicate that prox1 activity is crucial for the proper development of the otp1-positive hypothalamic neuronal precursors to their terminal CA phenotype