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In mouse embryonic stem cells, Cops2 binds to Nanog protein and prevent the degradation of Nanog by the proteasome.
Tip110 deletion impaired embryonic and stem cell development involving downregulation of stem cell factors Nanog, Oct4 (zeige POU5F1 Proteine), and Sox2 (zeige SOX2 Proteine).
Loss of phosphorylation enhances NANOG activity in reprogramming. Mutation S65A alone has the most significant impact on increasing NANOG reprogramming capacity.
Nanog, Oct4 (zeige POU5F1 Proteine) and Tet1 (zeige TET1 Proteine) interplay in establishing stem cell pluripotency has been described.
Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome.
Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains
Otx2 (zeige OTX2 Proteine)-mediated Nanog regulation contributes to the integrity of the embryonic stem cell state and cell lineage specification in preimplantation development (zeige MTA2 Proteine).
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine), and Nanog; Trim24 (zeige TRIM24 Proteine) significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
studies highlight a new hypoxia-induced pathway in which NANOG activates BNIP3L (zeige BNIP3L Proteine) expression, contributing to autophagy induction in hypoxic tumor cells and their resistance to killing by CTL
Genetic reporters can compromise the behavior of important pluripotency-sustaining positive feedback loops, and induce a bifurcation in the underlying dynamics that gives rise to heterogeneous Nanog expression patterns in reporter cell lines that are not representative of the wild-type; findings help explain the range of published observations of Nanog variability and highlight the problem of measurement in live cells.
Chicken egg-white extracts promote OCT4 and NANOG expression and telomeres growth in 293T cells.
Rectal tumor tissue OCT4 (p<0.001), SOX2 (p=0.003), and NANOG (p<0.001) expressions were higher than those in adjacent tissue.
Data show that lung adenocarcinoma SPC-A1 cell differentiated by a two-stage induction (TSI) method lost stem cell characteristics, including absent expression of OCT4 and Nanog.
Ino80 was upregulated in cervical cancer and promoted cell proliferation and tumorigenesis by binding to the Nanog transcription start site and enhancing its expression.
our data suggest that 3D culture increases the expression of Nanog through the relaxation of actin cytoskeleton, which mediates reduced Suv39h1 (zeige SUV39H1 Proteine) and H3K9me3 levels.
results show that NANOG could reverse the effects of stem cell senescence and restore the myogenic differentiation potential of senescent MSCs.
MACC1 (zeige MACC1 Proteine)-induced tumor progression in colorectal cancer acts, at least in part, via the newly discovered MACC1 (zeige MACC1 Proteine)/Nanog/Oct4 (zeige POU5F1 Proteine) axis.
RNAi-mediated silencing of NANOG in SKOV-3 reversed the expression of mesenchymal cell markers and restored expression of E-cadherin. Susceptibility to cisplatin increased in SKOV-3 cells on down-regulating NANOG and reversible results were obtained in Moody cells post-overexpression of NANOG.
NANOG enabled reactivation of the ROCK and Transforming Growth Factor (TGF)-beta pathways-both of which were impaired in senescent cells-leading to ACTIN polymerization, MRTF-A translocation into the nucleus and serum response factor (SRF)-dependent myogenic gene expression.
High NANOG expression is associated with brain neoplasms.
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Nanog displayed relatively the same methylation levels between sperm and oocytes
Noggin, a cytokine inhibiting the BMP4 pathway, successfully upregulated the relative expression of NANOG mRNA in the ICM explants with respect to controls.
Activin A (zeige INHBA Proteine) and overexpression of SMAD2 (zeige SMAD2 Proteine)/3 significantly promoted expressions of porcine NANOG and OCT4 (zeige POU5F1 Proteine),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 (zeige POU5F1 Proteine) expression.
the functional porcine NANOG that is different in chromosomal structure from mouse and human genes is a single exon gene and encodes the functional NANOG protein.
Results demonstrate that Nanog could interact with and activate other pluripotent genes both in porcine fetal fibroblasts and embryos.
Localisation of NANOG, OCT4 (zeige POU5F1 Proteine), and E-CADHERIN (zeige CDH1 Proteine) in porcine pre- and peri (zeige PLIN1 Proteine)-implantation embryos.
NANOG and SOX2 (zeige SOX2 Proteine) expression inversely correlated with the DNA methylation (zeige HELLS Proteine) pattern in the promoter region
report the isolation of complete coding regions of rabbit SOX2, KLF4, C-MYC and NANOG, which encode transcription factors that play crucial regulatory roles during early mammalian embryonic development
findings suggest that maternal Nanog coordinates several gene regulatory networks that shape the embryo during gastrulation.
These results indicate that zebrafish Nanog is necessary for proper yolk syncytial layer development but is not directly required for embryonic cell differentiation.
The authors show, at single-cell resolution in vivo, that Pou5f3 complexes with Nanog to pattern mesendoderm differentiation at the blastula stage.
Nanog has a role in supressing cell migration.
maternal Nanog, Pou5f1 (zeige POU5F1 Proteine) and SoxB1 are required to initiate the zygotic developmental program and induce clearance of the maternal program by activating miR (zeige MYLIP Proteine)-430 expression
Depletion of Nanog in zebrafish cannot be rescued by ectopic expression of Xvent, and Xvent depletion in Xenopus cannot be overcome by ectopic expression of zebrafish Nanog.
This study identified a Nanog-like-Mxtx2-Nodal pathway and establishes a role for Nanog-like in regulating the formation of the extraembryonic tissue required for endoderm induction.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, homeobox transcription factor Nanog-delta 48
, homeobox transcription factor NANOG
, Nanog homeobox
, nanog homeobox transcription factor
, homeodomain transcription factor Nanog
, LOW QUALITY PROTEIN: homeobox protein NANOG
, nanog homeobox
, ovary-expressed homeobox protein