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SNCA Proteine

(Synuclein, alpha (SNCA))

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].

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SNCA Protein (A53T)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active

Primary rat hippocampal neurons show lewy body inclusion formation when treated with A53T mutant Alpha Synuclein Protein Pre-formed Fibrils (ABIN6952303, ABIN6952304 and ABIN6952305) (B) but not when treated with a media control (A).

Evaluation of a-syn toxicity on primary mouse cortical neurons.

TEM of A53T alpha synuclein Pre-formed Fibrils (ABIN6952303, ABIN6952304 and ABIN6952305)

TEM of A53T alpha synuclein Pre-formed Fibrils (ABIN6952303, ABIN6952304 and ABIN6952305)

Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures such as those in alpha synuclein fibrils.

Evaluation of a-syn toxicity on primary mouse cortical neurons.

6 Abbildungen

Produktnummer ABIN6952303

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605,62 €

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100 μg

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Lieferung in 7 bis 9 Werktagen

SNCA Protein (full length)

SNCA Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active

SDS-PAGE of ~14 kDa Type 1 Mouse Recombinant Alpha Synuclein Protein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247).

TEM of Type 1 mouse alpha synuclein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247).

Primary rat hippocampal neurons show lewy body inclusion formation and loss of cells when treated with Type 1 mouse Alpha Synuclein Protein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247) at 4 μg/mL (D-F) on DVI2, but not when treated with a control (A-C).

C57/BL6 mice were injected with sonicated recombinant mouse alpha synuclein monomers or fibrils at 8 weeks of age.

C57/BL6 mice were injected with 5 μg sonicated mouse recombinant alpha synuclein PFFs (ABIN5651245, ABIN5651246 and ABIN5651247) at 8 weeks of age.

Immunohistochemistry analysis of rat brain injected with Type 1 mouse alpha synuclein PFFs (ABIN5651245, ABIN5651246 and ABIN5651247).

Primary mouse hippocampal neurons treated with 100 nM sonicated mouse alpha synuclein PFFs (ABIN5651245, ABIN5651246 and ABIN5651247) (A).

TEM of Type 1 mouse alpha synuclein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247).

Type 1 alpha synuclein Pre-formed Fibrils (ABIN5651245, ABIN5651246 and ABIN5651247) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (ABIN5651245, ABIN5651246 and ABIN5651247).

9 Abbildungen

Produktnummer ABIN5651245

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605,62 €

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100 μg

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Lieferung in 7 bis 9 Werktagen

SNCA Protein (full length)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95% pure using SDS-PAGE analysis. SDS, WB, in vitro, in vivo Active

SDS-PAGE of ~14 kDa Active Human Recombinant Alpha Synuclein Protein Aggregate .

Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) (Catalog No.

Primary rat hippocampal neurons show lewy body inclusion formation when treated with active Alpha Synuclein Protein Aggregate at 4 µg/ml (D-F), but not when treated with control Alpha Synuclein Protein Aggregate at 4 µg/ml (A-C).

Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (ABIN5065829, ABIN5065830 and ABIN5564165) at 4 μg/mL (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (ABIN5065829, ABIN5065830 and ABIN5564165) at 4 μg/mL (A-C).

ATTO633 fluorescently-labelled alpha synuclein PFFs (ABIN5065829, ABIN5065830 and ABIN5564165) were taken up, transported into the soma, and induced alpha synuclein aggregation in mouse neurocortical primary cells.

Confocal imaging shows NeuN+ (mature) primary cortical neurons filled with ATTO633 fluorescently-labelled alpha synuclein PFFs (ABIN5065829, ABIN5065830 and ABIN5564165).

Immunohistochemistry analysis of rat brain injected with Type 1 human alpha synuclein PFFs (ABIN5065829, ABIN5065830 and ABIN5564165).

TEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (ABIN5065829, ABIN5065830 and ABIN5564165)

Type 1 alpha synuclein Pre-formed Fibrils (ABIN5065829, ABIN5065830 and ABIN5564165) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (ABIN5065829, ABIN5065830 and ABIN5564165).

TEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (ABIN5065829, ABIN5065830 and ABIN5564165)

10 Abbildungen

Produktnummer ABIN5065829

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605,62 €

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100 μg

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Lieferung in 7 bis 9 Werktagen

SNCA Protein (AA 1-140) (His tag)

custom-made SNCA Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant SNCA Protein, UniprotID P37840

AlphaFold protein structure predicition of Human Recombinant SNCA Protein, UniprotID P37840

AlphaFold protein structure predicition of Human Recombinant SNCA Protein, UniprotID P37840

3 Abbildungen

Produktnummer ABIN7544253

ab

12.751,56 €

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1 mg

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Lieferung in 45 bis 71 Werktagen

SNCA Protein (AA 1-140) (His tag)

custom-made SNCA Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Mouse Recombinant Snca Protein, UniprotID O55042

AlphaFold protein structure predicition of Mouse Recombinant Snca Protein, UniprotID O55042

AlphaFold protein structure predicition of Mouse Recombinant Snca Protein, UniprotID O55042

3 Abbildungen

Produktnummer ABIN7562469

ab

12.751,56 €

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1 mg

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Lieferung in 45 bis 71 Werktagen

SNCA Protein

SNCA Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE

Western Blotting (WB) image for Synuclein, alpha (SNCA) protein (ABIN7320688)

1 image

Produktnummer ABIN7320688

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173,06 €

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50 μg (Weitere Mengeneinheiten)

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Lieferung in 9 bis 13 Werktagen

SNCA Protein (AA 1-140) (His tag)

SNCA Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA

Western Blotting (WB) image for Synuclein, alpha (SNCA) (AA 1-140) protein (His tag) (ABIN7125301)

1 image

Produktnummer ABIN7125301

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375,57 €

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50 μg (Weitere Mengeneinheiten)

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Lieferung in 11 bis 15 Werktagen

SNCA Protein (AA 1-140) (His-IF2DI Tag)

SNCA Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA

Western Blotting (WB) image for Synuclein, alpha (SNCA) (AA 1-140) protein (His-IF2DI Tag) (ABIN7125300)

1 image

Produktnummer ABIN7125300

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375,57 €

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50 μg (Weitere Mengeneinheiten)

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Lieferung in 11 bis 15 Werktagen

SNCA Protein (active)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % pure SDS

Figure annotation denotes ug of protein loaded and % gel used.

1 image

Produktnummer ABIN934871

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467,93 €

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100 μg

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Lieferung in 20 bis 26 Werktagen

SNCA Protein (AA 1-140) (GST tag)

SNCA Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA

Image no. 1 for Synuclein, alpha (SNCA) (AA 1-140) protein (GST tag) (ABIN1320774)

1 image

Produktnummer ABIN1320774

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530,40 €

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10 μg (Weitere Mengeneinheiten)

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Lieferung in 8 bis 9 Werktagen

SNCA Protein (AA 31-140) (GST tag)

SNCA Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA

Image no. 1 for Synuclein, alpha (SNCA) (AA 31-140) protein (GST tag) (ABIN1320776)

1 image

Produktnummer ABIN1320776

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530,40 €

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10 μg (Weitere Mengeneinheiten)

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Lieferung in 8 bis 9 Werktagen

SNCA Protein

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS

SDS-PAGE (SDS) image for Synuclein, alpha (SNCA) protein (ABIN666814)

1 image

Produktnummer ABIN666814

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624,43 €

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100 μg (Weitere Mengeneinheiten)

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Lieferung in 12 bis 16 Werktagen

SNCA Protein (AA 1-139, partial) (GST tag)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 90 % SDS, ELISA

SDS-PAGE (SDS) image for Synuclein, alpha (SNCA) (AA 1-139), (partial) protein (GST tag) (ABIN1046507)

1 image

3 Referenzen

Produktnummer ABIN1046507

460,90 €

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100 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 11 bis 15 Werktagen

SNCA Protein (AA 1-140) (His tag)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.

Produktnummer ABIN7505128

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162,86 €

~~191,60 €~~

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100 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 9 bis 13 Werktagen

SNCA Protein (AA 1-140) (His tag)

SNCA Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.

Produktnummer ABIN7505351

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162,86 €

~~191,60 €~~

Sparen Sie 28,74 € (-15 %)

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100 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 9 bis 13 Werktagen

SNCA Protein (AA 1-140)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.

Produktnummer ABIN1692153

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182,38 €

~~214,57 €~~

Sparen Sie 32,19 € (-15 %)

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50 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 8 bis 9 Werktagen

SNCA Protein (AA 1-140)

SNCA Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.

Produktnummer ABIN4371752

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196,09 €

~~230,69 €~~

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50 μg (Weitere Mengeneinheiten)

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Lieferung in 8 bis 9 Werktagen

SNCA Protein

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 97 % as determined by reducing SDS-PAGE.

Produktnummer ABIN7198176

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377,06 €

~~443,60 €~~

Sparen Sie 66,54 € (-15 %)

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100 μg (Weitere Mengeneinheiten)

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Lieferung in 9 bis 13 Werktagen

SNCA Protein (AA 1-140, K23Q) (His tag)

SNCA Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 85 % as determined by SDS-PAGE. WB, ELISA

Produktnummer ABIN7665674

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428,27 €

~~503,85 €~~

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50 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 13 bis 18 Werktagen

SNCA Protein (AA 23-140) (His tag)

SNCA Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, PC, Imm

Produktnummer ABIN7393487

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662,11 €

~~778,95 €~~

Sparen Sie 116,84 € (-15 %)

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100 μg (Weitere Mengeneinheiten)

Lieferung nach: Deutschland

Lieferung in 11 bis 15 Werktagen

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