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Gene expression level of NRD1 is significantly higher in AD patients when compared to normal controls.
MRNA expression of NRD1 was upregulated in 56% of ESCC tissue samples.
This study demonistrated that alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism.
possible roles of nardilysin in Alzheimer disease, Down syndrome, schizophrenia, mood disorders, alcohol abuse, heroin addiction and cancer; show that nardilysin is a Janus-faced enzyme with regard to brain pathology-- probably neuropathogenic in some diseases, but neuroprotective in others [review]
SH-SY5Y cells, stably transfected with green fluorescent protein-tagged-p42 (zeige EPB42 Proteine)(IP4) show enhanced NRD (zeige PRDM1 Proteine) protein expression already at an earlier time point after retinoic acid stimulation.
NRD1 interacts with p53 (zeige TP53 Proteine) mutant R273H
These results demonstrate that gastric cancer cell growth is maintained by autonomous TNF-alpha (zeige TNF Proteine)-NF-kappaB (zeige NFKB1 Proteine) and IL-6 (zeige IL6 Proteine)-STAT3 (zeige STAT3 Proteine) signalling, and that NRDc and ADAM proteases turn on these signalling cascades by stimulating ectodomain shedding of TNF-alpha (zeige TNF Proteine).
Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.
Several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample for KIAA0040, NRD1 and THSD7B, respectively.
Tubulin (zeige TUBB Proteine) potentiates the interaction of the metalloendopeptidase (zeige THOP1 Proteine) nardilysin with the neuronal scaffold protein (zeige HOMER1 Proteine) p42IP4 (zeige ADAP1 Proteine)/centaurin-alpha1 (ADAP1 (zeige ADAP1 Proteine)).
Nardilysin Is Required for Maintaining Pancreatic beta-Cell Function
deletion of nardilysin prevents the development of diet-induced steatohepatitis and liver fibrogenesis
The use of proteolysis to study the structure of nardilysin.
Studies extend the range of potential substrates for nardilysin and further substantiate that nardilysin is a true peptidase.
miniglucagon-generating endopeptidase is composed of NRDc and aminopeptidase B (zeige RNPEP Proteine) acting sequentially
role for nardilysin in oocyte meiosis through its dynamic translocation from cytosol to nucleus, and then to the spindle apparatus
NRDc regulates axonal maturation and myelination in the nervous system, in part, through the modulation of NRG1 (zeige NRG1 Proteine) shedding
The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase (zeige GSTa2 Proteine) and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain.
This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.
, N-arginine dibasic convertase 1
, nardilysin 1 (N-arginine dibasic convertase)
, nardilysin, N-arginine dibasic convertase 1
, nardilysin, N-arginine dibasic convertase, NRD convertase 1
, N-arginine dibasic convertase
, nardilysin (N-arginine dibasic convertase)
, Nardilysin-like protein