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This study shown that the genetic analysis revealed that the very early onset JMG had a more prominent genetic predisposition in an autoantigen gene (CHRNA1).
Data suggest that the mutations made the cholinergic receptor nicotinic alpha 1 subunit channel (CHRNA1) resistant to the antagonists, not by impairing antagonist binding, but rather by producing a gain-of-function phenotype, e.g. increased agonist sensitivity.
Study indicated that nicotinic acetylcholine receptor alpha 1-subunit peptides may act as receptor decoy molecules and inhibit the binding of virus to the native host cell receptors and hence may reduce viral infection.
ChRnA1 gene variants did not affect the pharmacodynamics of rocuronium.
Cholesterol and CAV-1 (zeige CAV1 Antikörper) modulate the function and dynamics of the slow channel congenital myasthenia syndrome alphaC418W nicotinic acetylcholine receptor mutation.
nicotine contributes to the progression and erlotinib-resistance of the NSCLC xenograft model via the cooperation between nAChR (zeige CHRNA4 Antikörper) and EGFR (zeige EGFR Antikörper).
show that AON complementary to the 5' splice site of the exon was the most effective at exon skipping of the minigene with causative mutations, as well as endogenous wild-type CHRNA1
The CHRNA1 extracellular domain is an improved protein for use in antigen-specific Myasthenia Gravis therapeutic strategies.
HnRNP L (zeige HNRNPL Antikörper) and hnRNP (zeige HNRNPC Antikörper) LL antagonistically modulate PTB (zeige PTBP1 Antikörper)-mediated splicing suppression of CHRNA1 pre-mRNA.
High expression of CHRNA1 is associated with lung adenocarcinoma after complete resection.
The results indicate that in the absence of the alpha1-nAChR (zeige CHRNA4 Antikörper) subunit, clusters of nAChRs coupled to SK2 (zeige PAPSS2 Antikörper) potassium channels as well as functional efferent synapses did form, showing that alpha1 is not necessary for these processes to take place.
This study demonstrates that genes coding for CHRNA1 subunits may contain variants associated with statin-induced ADRs.
Chrna1 was co-purified with nicotinic acetylcholine receptor (AChR) in C2C12 myotubes. In addition, Stau1 (zeige STAU1 Antikörper) was found to interact with Chrna1 mRNA, and knocking down of Stau1 (zeige STAU1 Antikörper) by RNAi resulted in defective AChR clustering.
These results suggest that in skeletal muscle cells, neural activity reduces the molar ratio of YB-1 (zeige YBX1 Antikörper) relative to its binding AChR alpha mRNA, leading to an increase of ribosome binding to the mRNA, and thus activating translation.
Chrna1 could be the first transcriptional target of atonal homolog 1 in the inner ear
These data identify caveolin-3 (zeige CAV3 Antikörper) as a critical component of the signaling machinery that drives nicotinic acetylcholine receptor clustering and controls neuromuscular junction function.
HDAC4 (zeige HDAC5 Antikörper) is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2 (zeige DACH2 Antikörper), myogenin (zeige MYOG Antikörper), and nAChR (zeige CHRNA4 Antikörper)
In S269I, mutant the peak-current amplitude decreases along trains of nearly saturating ACh (zeige FGFR3 Antikörper) pulses delivered at physiologically relevant frequencies, consistent with enhanced entry into desensitization in congenital myasthenic syndrome.
In this mouse experiemntal myasthenia gravis study demonstrated that Acetylcholine receptor (zeige CHRNB1 Antikörper)-alpha1 subunit expression was increase with varying disease severity.
The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.
acetylcholine receptor subunit alpha
, acetylcholine receptor, nicotinic, alpha 1 (muscle)
, cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
, muscle nicotinic acetylcholine receptor
, nicotinic acetylcholine receptor alpha subunit
, nicotinic cholinergic receptor alpha 1
, muscle nicotinic acetylcholine receptor alpha-su exon P4
, nachr alpha-subunit
, nicotinic acetylcholine recepter alpha-subunit
, cholinergic receptor nicotinic alpha polypeptide 1
, alpha-1 subunit, nicotinic acetylcholine receptor
, nicotinic cholinergic receptor alpha polypeptide 1