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Data show that an indispensable beta-subunit (zeige POLG Proteine) of the voltage-gated Ca(2 (zeige CA2 Proteine)+) channel Cav1.2 (zeige CACNA1C Proteine) interaction with H-Ras (zeige HRAS Proteine) is independently of Ca(2 (zeige CA2 Proteine)+) flux, suggesting the regulatory role of beta2 in transcriptional activation via the ERK (zeige EPHB2 Proteine)/CREB (zeige CREB1 Proteine) pathway.
Our study shows that palmitoylation of CaVbeta2a is necessary for CaValpha1 trafficking to the plasma membrane. However, excessive number of palmitoylated CaVbeta2a leads to Ca(2 (zeige CA2 Proteine)+) overload and beta cell death.
Study showed that CACNB2 is a possible candidate hypertrophy-modifying gene contributing to disease variability of MYBPC3 (zeige MYBPC3 Proteine)-associated familial hypertrophic cardiomyopathy
Five serious mental disorders and three major cardiovascular diseases have recently been linked to the CACNB2 gene coding for the Cavbeta2 subunits
ADM (zeige ADM Proteine) genotype AA was associated with the highest values of systolic and diastolic blood pressure (BP), while CACNB2 genotype CC carriers had the highest values of diastolic BP in childhood.
In the gene-based analysis, CACNB2 and CTCF (zeige CTCF Proteine) showed the strongest evidence for association with schizophrenia in both the present samples and in those of the Psychiatric Genetics Consortium datasets.
Chronic atrial fibrillation increases miR (zeige MLXIP Proteine)-21 expression in human atrial myocytes and decreases I(Ca,L) density by downregulating CACNA1C (zeige CACNA1C Proteine)/CACNB2 expression.
Three rare missense mutations of CACNB2 (G167S, S197F, and F240L) found in Autism Spectrum Disorders (ASD (zeige ARSD Proteine))-affected families, are reported.
High prevalence of CACNA2D1 (zeige CACNA2D1 Proteine), SCN5A (zeige SCN5A Proteine), and CACNB2 genetic variants in the Danish population previously associated with Brugada syndrome has been found in new exome data.
Association of the SNP rs2932538 in MOV10 and SNP rs4373814 in CACNB2 with an increased risk of hypertension in a Chinese Han population.
L-type Ca2 (zeige CA2 Proteine)+ channels in the caveolae microdomain do not affect cardiac function and are not necessary for the regulation of hypertrophic signaling in the adult mouse heart.
Many hormone- or neurotransmitter-activated receptors stimulate PIP2 hydrolysis and increase cytosolic Ca(2 (zeige CA2 Proteine)+); thus, our findings suggest that beta2e may integrate such receptor-mediated signals to limit Cav (zeige CA5A Proteine) activity.
Membrane Interaction of the beta2e Subunit of Voltage-Gated Ca(2 (zeige CA2 Proteine)+) Channels
Dynamic phospholipid interaction of beta2e subunit regulates the gating of voltage-gated Ca2 (zeige CA2 Proteine)+ channels.
a model in which CaVbeta promotes anterograde trafficking of the L-type channels by anchoring them to actin filaments in their itinerary to the plasma membrane.
We conclude that phosphorylation of the C-terminal sites in Ca(v)beta(2), Ser (zeige SIGLEC1 Proteine)(1928), Ser (zeige SIGLEC1 Proteine)(1512), and Ser (zeige SIGLEC1 Proteine)(1570) of the Ca(v)1.2 (zeige CACNA1C Proteine) protein is functionally not involved in the adrenergic regulation of the murine cardiac Ca(v)1.2 (zeige CACNA1C Proteine) channel.
phosphorylation event is one mechanism underlying ahnak1 (zeige AHNAK Proteine)'s modulator function on Cav1.2 (zeige CACNA1C Proteine) channel activity.
Mice with cardiac-specific sequestration of the beta-subunit (zeige POLG Proteine) of the L-type calcium channel
preferential binding between Cacna1c (zeige CACNA1C Proteine) and Cacnb2 in the heart
Ca(V)beta(2) has an essential role in regulating the abundance and properties of Ca(V)1.3 (zeige CACNA1D Proteine) channels in IHCs and, thereby, is critical for IHC development and synaptic encoding of sound.
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described.
, calcium channel voltage-dependent subunit beta 2
, lambert-Eaton myasthenic syndrome antigen B
, myasthenic (Lambert-Eaton) syndrome antigen B
, voltage-dependent L-type calcium channel subunit beta-2
, cardiac calcium channel beta subunit
, cardiac calcium channel beta-subunit
, calcium channel, voltage-dependent, beta 2 subunit
, L-type calcium channel beta subunit
, voltage-dependent L-type calcium channel subunit beta-2-like
, calcium channel, voltage-dependent, beta 2b