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SKP2 Proteine

(S-Phase Kinase-Associated Protein 2 (SKP2))
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class\; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011].

10 Treffer

custom-made SKP2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7555572
 
custom-made SKP2 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7556363
 
SKP2 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Produktnummer ABIN1320091
 
SKP2 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Pubmed 1 reference
Produktnummer ABIN2732125
 
SKP2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, ELISA
Produktnummer ABIN7579521
 
SKP2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS, WB, Imm, PC
Produktnummer ABIN7413499
 
custom-made SKP2 Spezies: Maus Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA
Produktnummer ABIN3120254
 
custom-made SKP2 Spezies: Human Wirt: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA
Produktnummer ABIN3095574
 
SKP2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Produktnummer ABIN5711247
 
SKP2 Spezies: Human Recombinant
Produktnummer ABIN1067220
 
  • Typ Protein
    • Protein
  • Anwendung
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • ELISA
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Antibody Production (AbP)
    • Immunogen (Imm)
    • Positive Control (PC)
    • Standard (STD)
  • Reaktivität
    • Human
    • Mouse
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Carrier free only
  • Wirt
    • Escherichia coli (E. coli)
    • HEK-293 Cells
    • Cell-free protein synthesis (CFPS)
    • Wheat germ
  • Bindungsspezifität
    • AA 1-424
    • AA 43-397
    • Transcript Variant 1
    • full length
  • Konjugat
    • His tag
    • Strep Tag
    • GST tag
    • His-SUMO Tag
    • Myc-DYKDDDDK Tag
    • Unkonjugiert
  • Protein-Typ
    • Recombinant
  • Format
    • Liquid
    • Lyophilized
  • Grade
    • custom-made
  • Hersteller
    • antibodies-online
    • ITSI-Biosciences
    • OriGene
    • Signalway

Aktuelle Publikationen für unsere SKP2 Proteine

Wen, Wang, Yang: "Inhibiting the role of Skp2 suppresses cell proliferation and tumorigenesis of human gastric cancer cells via the upregulation of p27kip1." in: Molecular medicine reports, Vol. 14, Issue 4, pp. 3917-24, (2016) (PubMed).

Aliase für SKP2 Proteine

S-phase kinase-associated protein 2 (p45) (Skp2) Proteine
S-phase kinase associated protein 2 (SKP2) Proteine
S-phase kinase associated protein 2 (Skp2) Proteine
FBL1 Proteine
FBXL1 Proteine
FLB1 Proteine
p45 Proteine
RGD1562456 Proteine
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