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These observations support the notion that a major function of Myosin VI in the nerve terminal is tethering synaptic vesicles to proper sub-cellular location within the bouton
These data demonstrate that generating an organized and functional actin (zeige ACTB Proteine) structure in this cell requires multiple activities coordinated by myosin VI.
The androcam structure and its binding to the myosin VI structural (Insert 2) and regulatory (IQ) light chain sites are distinct from those of calmodulin.
data indicate that myosin V (zeige MYO5A Proteine) and VI, but not II, play related but distinct roles in regulating microtubule (MT)-based mitochondrial movement: they oppose, rather than complement, protracted MT-based movements and perhaps facilitate organelle docking
MyoVI is required for border cell migration where it stabilizes E-cadherin (zeige CDH1 Proteine) and Arm.
Myosin VI is crucial for correct cell morphology and maintenance of adhesive cellular contacts within epithelial cell layers.
Myosin VI stabilizes a branched actin network in actin structures (cones) that mediate the separation of the syncytial spermatids. I
The spatial and temporal expression of Myosin VI was examined by expressing a Green Fluorescent Protein tagged Myosin VI molecule, under the control of a Myosin VI-Gal4 (zeige LGALS4 Proteine) line.
Data suggest that Echinoid mediates the dimerization of myosin VI/Jaguar in vivo which in turn regulates the reorganization and/or contraction of actin (zeige ACTB Proteine) filaments to control changes in cell shape.
Miranda protein forms an apical crescent at interphase, but is ubiquitously localized at prophase in a Myosin-II-dependent manner.
Backfolding of MVI regulates its ability to bind DNA and that a putative transcription co-activator NDP52 (zeige CALCOCO2 Proteine) relieves the auto-inhibition of MVI to enable DNA binding. Additionally, we show that the MVI-NDP52 (zeige CALCOCO2 Proteine) complex binds RNAPII, which is critical for transcription, and that depletion of NDP52 (zeige CALCOCO2 Proteine) or MVI reduces steady-state mRNA levels.
The tumorigenic effect of lncRNA SOX21 (zeige SOX21 Proteine)-AS1 (zeige PTGDR Proteine) in CRC (zeige CALR Proteine) cells via targeting miR (zeige MLXIP Proteine)-145/MYO6, providing a novel insight for CRC (zeige CALR Proteine) carcinogenesis.
Rab33b (zeige RAB33B Proteine), OATL1 (zeige TBC1D25 Proteine) and Myo6 have roles in nanoparticle trafficking in HeLa cells
miR (zeige MLXIP Proteine)-143 and miR (zeige MLXIP Proteine)-145 suppress gastric cancer cell migration and metastasis by inhibiting MYO6 expression and the epithelial-mesenchymal transition, which provides a novel mechanism and promising therapeutic target for the treatment of gastric cancer metastasis.
MYO6 facilitates Salmonella invasion.Salmonella virulence effector SopB (zeige IFT122 Proteine) requires MYO6 to regulate the localization of phosphoinositides and Akt (zeige AKT1 Proteine) activation.
Data indicate filopodia formation and MYO6 motor function at endosomes and at the plasma membrane.
we describe a novel nonsense MYO6 mutation that was responsible for the hearing loss in a Brazilian family
this is the first ILDR1 (zeige ILDR1 Proteine) and MYO6 mutations recognized in the southwest Iran. Our data expands the spectrum of mutations in ILDR1 (zeige ILDR1 Proteine) and MYO6 genes
MYO6 could play an essential role in the growth of OSCC cells via regulation of cell cycle progression and apoptosis.
characterisation of the human myosin VI deafness mutant (R1166X) suggests that defects in cargo binding may leave myosin VI in a primed/activated state with an increased actin-binding ability
Loss of MYO6 results in an accumulation of mitophagosomes and an increase in mitochondrial mass.
both AKT phosphorylation and RAC-dependent membrane ruffling were markedly reduced by depletion of either APPL1 or MYO6. These results place MYO6 and its binding partners at a central nexus in cellular signaling linking actin dynamics at the cell surface and endosomal signaling in the cell cortex.
GIPC1 (zeige GIPC1 Proteine) forms a domain-swapped dimer in an autoinhibited conformation that hinders binding of both PlexinD1 and myosin VI. PlexinD1 binding to GIPC1 (zeige GIPC1 Proteine) releases the autoinhibition, promoting its interaction with myosin VI. GIPCs and myosin VI interact through two distinct interfaces and form an open-ended alternating array.
indicated that decreased MYO6 levels in ksv/ksv mutants disrupt actin networks in the apical region of hair cells, thereby maintaining the normal structure of the cuticular plates and rootlets, and additionally provided a cellular basis for stereociliary fusion in Myo6 mutants
We propose that myosin VI, by removing stereociliary elements such as CDH23 (zeige CDH23 Proteine) as a component of the transient lateral links (which are probably required for the integrity of the immature hair bundles), allows the hair bundle and its transduction apparatus to progress in their development, so that the mechano-electrical transducer channels acquire their physiological resting tension and Ca2 (zeige CA2 Proteine)+-dependent adaptation properties
a plaque accretion defect as the primary manifestation of myosin VI loss in Cx43 (zeige GJA1 Proteine) homeostasis, is reported.
the Turner mutation was mapped to a critical region of 11 cM on chromosome 9 that includes myosin VI.
Myo1a (zeige MYO1A Proteine) and Myo6 play essential roles in response to intestinal mucosal injury
Disruption in optineurin (zeige OPTN Proteine) and myosin VI-mediated cellular trafficking is associated with amyotrophic lateral sclerosis.
We postulate that this novel interaction linking MVI with the PKA pathway could be important for targeting AKAP9-PKA complex within cells and/or providing PKA to phosphorylate MVI tail domain.
Studied the crystal structure of myosin VI, (the pretransition state (PTS (zeige PTS Proteine))), in particular the recovery stroke of Myosin VI, which was solved at 2.2 A resolution.
Data suggest that cells direct the movement of vesicles around a cell by altering the relative number of myosin Va (zeige MYO5A Proteine) from Gallus gallus and myosin VI from Sus scrofa.
A myosin VI deafness mutation, D179Y, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (Pi), from dependency on actin binding and destroyed the ability of single dimeric molecules to move processively on actin filaments.
model reveals that myosin VI, unlike plus-end directed myosins, does not use a pure lever arm mechanism, but instead steps with a mechanism analogous to the kinesin neck-linker uncoupling mode
The stepping dynamics of single quantum-dot-labeled myoV and myoVI motors linked to a common cargo, was studied.
These results suggest that myosin VI kinetics are tuned such that the motor maintains a consistent level of mechanical tension within the cell, a property potentially shared by other mechanosensitive proteins.
a mechanism is proposed of myosin VI stepping that predicts a regulation through load of the motor's roles as transporter and anchor
2.4-A structure of a truncated version of the reverse-direction myosin motor, myosin VI, that contains the motor domain and binding sites for two calmodulin molecules
Data demonstrate that full-length myosin VI is capable of forming stable, processive dimers when monomers are clustered, which move up to 1-2 mum in approximately 30 nm, hand-over-hand steps.
further adaptations within the motor increase the magnitude and variability of the plus-end directed converter movements, and unexpectedly provide the source of the highly variable myosin VI step size
MVI, but not myosins IB or IIB, was detected in chromaffin granules isolated from bovine medulla and found to be tightly associated with the granule apical surface.
This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss.
, 95F unconventional myosin
, myosin 95F
, myosin VI
, myosin heavy chain
, myosin heavy chain at 95F
, unconventional myosin VI
, unconventional myosin-6
, unconventional myosin-VI
, Snell's waltzer
, unconventional myosin