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anti-Human GRM7 Antikörper:
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Cow (Bovine) Polyclonal GRM7 Primary Antibody für IHC (p), WB - ABIN4334140
Friedman, Van Laer, Huentelman, Sheth, Van Eyken, Corneveaux, Tembe, Halperin, Thorburn, Thys, Bonneux, Fransen, Huyghe, Pyykkö, Cremers, Kremer, Dhooge, Stephens, Orzan, Pfister, Bille, Parving et al.: GRM7 variants confer susceptibility to age-related hearing impairment. ... in Human molecular genetics 2009
Show all 2 Pubmed References
Human Polyclonal GRM7 Primary Antibody für ELISA, WB - ABIN447400
Vadasz, Saito, Gyetvai, Oros, Szakall, Kovacs, Prasad, Toth: Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking. in Genomics 2007
The present study showed that the genetic polymorphisms of GRM7 are associated with susceptibility to Age-related Hearing Impairment. The SNP rs9880404 was found to be associated with increased risk for ARHI in a dominant pattern. SNPs rs11928865, rs1353828, and rs9814809 were found not to be associated with susceptibility to ARHI .
GRM7 rs779867 was associated with multiple sclerosis (MS) risk in recessive model. There was no significant difference in allele and genotype frequencies of rs6782011 between cases and controls. None of the estimated haplotype blocks of rs6782011 and rs779867 were associated with MS risk in the assessed population.
The mutant allele C in rs1485175 of the GMR7 may decrease individuals' susceptibility to noise-induced hearing loss.
The results of this study indicate that the GRM7 rs9814881 might be associated with MDD in the Chinese Han population.
study to evaluate evidence for association between GRM7 and alcohol behaviors using an SNP approach, as well as a gene-based approach in two independent samples; Rs3749380 was suggestively associated with alcohol consumption in one sample with the minor T allele conferring risk; there was no evidence for association in the other sample
Autism spectrum disorder (ASD) as a synaptopathy is revealed to be pertained to aberrant glutamatergic neurotransmission. Glutamate receptor, metabotropic 7 (GRM7) is a receptor coding gene of this pathway.
GRM7 rs2133450 may have translational relevance as a predictor of response to risperidone in schizophrenia.
Multiple genetic models identified 1 significant locus, GRM7, for 2 hypertension-derived traits.
Study represents a genetic association test towards single variant and multi-markers interaction of GRM7 and GRM8 genes in both schizophrenia and major depressive disorders in Han Chinese population
Glutamate system genes have been associated with disease risk in recent analyses from the Psychiatric Genomics Consortium.
results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population.
results reported here do not support a role for GRM7 in ADHD
Copy number variants at GRM7 may have a role in the etiology of bipolar disorder.
For neither PCLO nor GRM7 we found a more associated variant. For SLC6A4, we found a new SNP that showed a lower P-value than in the GAIN-MDD GWAS
in an elderly male Han Chinese population, GRM7 SNP rs11928865 (TT) occurs more frequently in age-related hearing impairment patients with SL and AL phenotype patterns.
These results provide preliminary evidence of an association between the GRM7 rs37952452 polymorphism and selective attention deficit and anxiety found within the Korean ADHD population
Mixed modeling analyses explored the relationship of GRM7 haplotype and SNP genotypes with measures of auditory perception. GRM7 alleles are associated primarily with peripheral measures of hearing loss, and with speech detection in older adults.
SNPs in autism spectrum disorders
Copy number variations within GRM7 are not associated with schizophrenia in the Han Chinese population.
This suggests that 3p25-26 is a new locus for severe recurrent depression. This represents the first report of a genome-wide significant locus for depression that also has an independent genome-wide significant replication.
We found a significant reduction of testosterone levels in mGluR7 knockout (KO) mice. Social investigating behaviour of intact mGluR7 KO mice also differed from that of wild-type mice; e.g. the KO mice showing less frequent anogenital sniffing and more frequent grooming behaviour. Further, castrated mGluR7 KO mice have smaller seminal vesicles than those of castrated wild-type mice, although intact mice were no different.
Altered mGlu7 expression was found in brain regions associated with fear extinction in two different mouse strains which differ in their fear extinction behavior.
mGlu7 may be a potential therapeutic target for multiple aspects of the Rett phenotype.
The mGlu7 receptor was found to be involved in a wide range of behavioral and physiological alterations in response to chronic psychosocial stress exposure.
This study provides evidence for mGlu7 receptor-mediated tonic modulation of a physiological function in vivo preventing synchronous and potentially pathological oscillations.
Analysis of mGluR7 KO mice, c-Fos expression, and cerebral MMPIP microinjection indicate that inhibition of mGluR7 impairs intermale aggression owing to information processing dysfunction within the bed nucleus of the stria terminalis
muscle does not appear to require high levels of SMN above what is produced by two copies of SMN2
SAM68 is a physiological regulator of SMN2 splicing in a spinal muscular atrophy mouse model.
Hyperoxia treatment increased the inclusion of SMN2 exon 7 in skeletal muscles and resulted in improved motor function.
Elfn1 recruits mGluR7 to synaptic sites.A trans interaction of Elfn1 and mGluR7 controls targeted interneuron synapse development.
GRM7 regulates the phosphorylation of CREB protein and the expression of Yes-associated protein (YAP) by directly interacting with CaM, which subsequently regulates the expression of CyclinD1 and ultimately affects early cortical development.
Modeling the selective interaction between XAP044 and mGlu7's Venus flytrap domain, whose three-dimensional structure is already known, will facilitate future drug development supported by computer-assisted drug design
The data of this study revealed very different roles for mGlu7 in amygdala synaptic transmission, fear learning and its expression
These data suggest targeting mGlu7 receptors with selective antagonist drugs may be an effective and safe strategy for the treatment of anxiety disorders.
Glutamate release mediated by GluR7 at nerve terminals is influenced by divalent calcium channel type Ca2+ ionophore.
mGluR7, by affecting the cofilin/actin signaling, regulates NMDAR trafficking and function
The genomic integration site of the mGluR7 transgene is in intron 4 in spinal muscular atrophy transgenic mice, especially those that have extended survival.
Phorbol esters and prolonged activation of mGlu7 receptors both potentiate glutamate release via a common intracellular signalling pathway that occurs in nerve terminals containing N-type divalent calcium channels.
This study suggested that mGlu7 receptor is involved in the regulation of GABAergic system activity at the level of GABA synthesised enzymes, specific proteins expressed by GABAergic neurons and metabotropic receptor for GABA.
mGlu7 receptors may not only regulate the central components of chronic stress, but may also have a role in the regulation of fluid & electrolyte transport which is significantly disrupted in diseases such as IBS, by enhancing colonic secretory activity
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
metabotropic glutamate receptor 7
, G protein-coupled receptor GRM7
, G protein-coupled receptor, family C, group 1, member G
, mGlu7a receptor
, metabotropic glutamate receptor mGluR7
, metabotropic glutamate receptor subtype 7b