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Our results indicated that COL1A1 rs1800012 polymorphism may be associated with the reduced risk of sports-related tendon or ligament injuries, especially in ACL (zeige ACLY Proteine) injuries, and that rare TT may played as a protective role.
Breast cancer cells alter the dynamics of stromal fibronectin (zeige FN1 Proteine)-collagen interactions.
COL1a1 crystal structure of fibronectin (zeige FN1 Proteine) type III domain shows an immunoglobulin-like fold containing a beta (zeige SUCLA2 Proteine)-sandwich structure, which is formed by a three-stranded beta-sheet.
Strong correlations between the expression of type I, II, IV collagen and osteopontin (zeige SPP1 Proteine) and the clinical stage of tympanosclerosis indicate the involvement of these proteins in excessive fibrosis and pathological remodeling of the tympanic membrane.
The results support the association of COL1A1 gene polymorphisms with fracture and with low BMD (zeige BEST1 Proteine) at the hip in Mexican population
Abnormal regulation of COL1 and COL3 may contribute to the early predisposition to POP (zeige PREP Proteine) in premenopausal women.
Genetic variation in COL1A1 and COL1A2 (zeige COL1A2 Proteine) associated with osteogenesis imperfect in Vietnamese patients.
2 patients with osteogenesis imperfecta (zeige COL1A2 Proteine) (father and daughter) had a previously undescribed c.3607C>T (p.Gln1203*) change in the COL1A1 gene.
In the patient diagnosed with PCG and retinal detachment, analysis of WES data identified compound heterozygous variants in COL1A1 (p.Met264Leu; p.Ala1083Thr).
These data, together with those available in literature, suggest that vascular events are not a diagnostic handle to differentiate patients with the p.(Arg312Cys) COL1A1 mutation from those with COL5A1 and COL5A2 defects, and highlight that during the diagnostic process the presence of at least the p.(Arg312Cys) substitution in COL1A1 should be investigated in cEDS patients without type V collagen mutations.
Our studies demonstrate that a collagen-I-dense ECM (zeige MMRN1 Proteine) can potently alter hormonal signals to drive the progression of ERalpha (zeige ESR1 Proteine) + breast cancer, increasing intravasation and pulmonary metastases.
a surface population of Hsp90 (zeige HSP90 Proteine) extracellularly binds TGFbetaRI and this complex behaves as an active participant in collagen production in TGFbeta (zeige TGFB1 Proteine)-activated fibroblasts.
osthole could inhibit the collagen I and III expressions and their ratio in CFs treated with TGF-beta1 (zeige TGFB1 Proteine) via Smad (zeige SMAD1 Proteine) signaling pathway, which might be one of its anti-fibrotic action mechanisms.
Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA (zeige SMN1 Proteine), and COL1a1 expression in a liver fibrosis disease model.
Type I collagen was highly expressed in the spinal cord during the scar-forming phase and induced astrocytic scar formation via the integrin-N-cadherin (zeige CDH2 Proteine) pathway.
collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI (zeige GP6 Proteine).
miR (zeige MLXIP Proteine)-29b can reduce collagen biosynthesis during skin wound healing likely via post-transcriptional inhibition of HSP47 (zeige SERPINH1 Proteine) expression.
Col1a1Jrt/+ mutant mice produce craniofacial and dental defects consistent with osteogenesis imperfecta (zeige COL1A2 Proteine) and Ehlers-Danlos syndrome
the rate of collagen I degradation was increased in Poldip2 (zeige POLDIP2 Proteine)(+/-) vs. Poldip2 (zeige POLDIP2 Proteine)(+/+) MASMs. Conversely, activation of the PI3K/Akt (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) signaling pathway, involved in regulation of protein synthesis, was significantly elevated in Poldip2 (zeige POLDIP2 Proteine)(+/-) MASMs as was beta1-integrin expression.
Col1 expression was seen in the cartilage zone of the mandibular condyle cartilage.
These observations support a signaling network among JNKs, Smads, Snail1 (zeige SNAI1 Proteine), and cortactin (zeige CTTN Proteine) to regulate the invasion of MDA-MB-231 cells embedded in 3D collagen I, which may be targeted during screening of anti-invasion reagents.
Data show that biglycan (zeige BGN Proteine), collagen type I, collagen type II, decorin (zeige DCN Proteine), and versican (zeige Vcan Proteine) were significantly affected by vibration duration, frequency, and amplitude.
specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V
In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen (zeige COL1A2 Proteine)
These results demonstrate a novel and important functional role of the DDR2 (zeige DDR2 Proteine) extracellular domain that may contribute to collagen regulation via modulation of fibrillogenesis.
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
A molecular model of collagen hydration is used to validate centrifugal dehydration force (CDF (zeige CTNNA2 Proteine)) and re-hydration isotherm (RHI) methods to measure and characterize hydration compartments on bovine tendon.
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
collagen, type I, alpha 1
, alpha 1 type I collagen
, collagen, type I, alpha 2
, collagen type I alpha 1
, procollagen alpha 1 (I)
, collagen 1a1
, alpha-1 type I collagen
, collagen alpha 1 chain type I
, collagen alpha-1(I) chain
, collagen alpha-1(I) chain preproprotein
, collagen of skin, tendon and bone, alpha-1 chain
, pro-alpha-1 collagen type 1
, alpha-1 type 1 collagen
, procollagen, type I, alpha 1
, alpha-1 collagen (I)
, collagen alpha-1 chain
, type I collagen pre-pro-alpha1(I) chain
, prepro-alpha-1 collagen type I
, type I collagen alpha 1 chain
, type I collagen alpha1
, pro-alpha-1 type 1 collagen
, collagen, type 1, alpha 1
, procollagen type I, alpha 1
, procollagen, type 1, alpha 1