Maus anti-Human IgM (Heavy Chain) Antikörper

Produktnummer ABIN7879457

Kurzübersicht für Maus anti-Human IgM (Heavy Chain) Antikörper (ABIN7879457)

Target: IgM

Klonalität: Monoklonal

Applikation: ELISA

Güteklasse: Carrier-free

Klon: IGHM-1623

Isotyp: IgG1, kappa

Produktdetails

Bindungsspezifität: Heavy Chain

Reaktivität: Human

Wirt: Maus

Verwendungszweck: IgM Antibody (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: The heavy chain of human IgM was used as the immunogen for the IgM antibody.

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IgM antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the IgM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Antigendetails

Target: IgM

Substanzklasse: Antibody

Hintergrund: Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01871