Maus anti-Human IgM (Heavy Chain) Antikörper

Produktnummer ABIN7879456

Kurzübersicht für Maus anti-Human IgM (Heavy Chain) Antikörper (ABIN7879456)

Target: IgM

Klonalität: Monoklonal

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: R1-69

Isotyp: IgG1, kappa

Produktdetails

Bindungsspezifität: Heavy Chain

Reaktivität: Human

Wirt: Maus

Verwendungszweck: IgM Heavy Chain Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: Heavy chain of human IgM was used as the immunogen for the IgM Heavy Chain antibody.

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IgM Heavy Chain antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the IgM Heavy Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Antigendetails

Target: IgM

Substanzklasse: Antibody

Hintergrund: Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01871