Rekombinanter Kaninchen anti-Human IgM (Heavy Chain) Antikörper

Produktnummer ABIN7879451

Kurzübersicht für Rekombinanter Kaninchen anti-Human IgM (Heavy Chain) Antikörper (ABIN7879451)

Target: IgM

Antikörpertyp: Recombinant Antibody

Klonalität: Monoklonal

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: IGHM-2557R

Isotyp: IgG, kappa

Produktdetails

Bindungsspezifität: Heavy Chain

Reaktivität: Human

Wirt: Kaninchen

Verwendungszweck: Recombinant IgM Antibody (azide and preservative free)

Aufreinigung: Protein A affinity chromatography

Immunogen: Heavy chain of human IgM was used as the immunogen for the recombinant IgM antibody.

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant IgM antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant IgM antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Antigendetails

Target: IgM

Substanzklasse: Antibody

Hintergrund: Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01871