Maus anti-Human IgA (Heavy Chain) Antikörper (CF®488A)

Produktnummer ABIN7879448

Kurzübersicht für Maus anti-Human IgA (Heavy Chain) Antikörper (CF®488A) (ABIN7879448)

Target: IgA

Klonalität: Monoklonal

Konjugat: CF®488A

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: IA761

Isotyp: IgG1, kappa

Produktdetails

Bindungsspezifität: Heavy Chain

Reaktivität: Human

Wirt: Maus

Verwendungszweck: IgA Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: Purified human immunoglobulin alpha heavy chain was used as the immunogen for the Anti-IgA antibody.

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IgA antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 500 µL at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the IgA antibody at 2-8oC, protected from light.

Antigendetails

Target: IgA

Substanzklasse: Antibody

Hintergrund: This MAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins.IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin's lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

UniProt: P01876