Maus anti-Human IgM (Chain mu), (Fab Region) Antikörper

Produktnummer ABIN371468

Kurzübersicht für Maus anti-Human IgM (Chain mu), (Fab Region) Antikörper (ABIN371468)

Target: IgM

Klonalität: Monoklonal

Applikation: Immunofluorescence (IF), Enzyme Immunoassay (EIA), Functional Studies (Func)

Klon: UHB

Isotyp: IgG3

Produktdetails

Bindungsspezifität: Chain mu, Fab Region

Reaktivität: Human

Wirt: Maus

Aufreinigung: Purified

Anwendungsinformationen

Applikationshinweise: Human B Cell Stimulation: < / = 10 μg/mL.

Other applications not tested.
Otimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.25 mg/mL

Buffer: Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -28 °C for longer.

Antigendetails

Target: IgM

Substanzklasse: Antibody

Hintergrund: IgM normally constitutes about 10 % of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.Synonyms: Human Immunoglobulin M