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anti-Human WASF3 Antikörper:
anti-Mouse (Murine) WASF3 Antikörper:
anti-Rat (Rattus) WASF3 Antikörper:
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Study demonstrated that the expression levels of WAVE3 in pancreatic cancer tissues were prominently higher than those in the non-cancerous tissues which seems to be associated with lymphatic metastasis, poorly differentiated tumors. Furthermore, findings suggest that WAVE3 influences cell proliferation, migration and invasion via the AKT (zeige AKT1 Antikörper) pathway.
Results suggest that Wiskott-Aldrich syndrome verprolin-homologous protein 3 (zeige HSPB3 Antikörper) (WAVE3) may be pivotal in ovarian cancer cell motility, invasion and oncogenesis.
p63alpha protein up-regulates heat shock protein 70 (zeige HSP70 Antikörper) expression via E2F1 transcription factor (zeige E2F1 Antikörper) 1 (zeige HNF1A Antikörper), promoting Wasf3/Wave3/MMP9 (zeige MMP9 Antikörper) signaling and bladder cancer invasion
we show that WASF3 is present in the HER2 (zeige ERBB2 Antikörper) immunocomplex and suppression of WASF3 function leads to suppression of invasion even in the presence of HER2 (zeige ERBB2 Antikörper) expression.The engagement of WASF3 with the HER2 (zeige ERBB2 Antikörper)/HER3 (zeige ERBB3 Antikörper) complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2 (zeige ERBB2 Antikörper)/HER3 (zeige ERBB3 Antikörper) activation of JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) signaling.
we show that stapled peptides targeting the interface between NCKAP1 (zeige NCKAP1 Antikörper) and CYFIP1 (zeige CYFIP1 Antikörper) destabilize the WASF3 complex... thereby suppressing invasion and metastasis of breast cancer cells.
It was concluded that WAVE3 may represent a new adverse prognostic factor for patients with ICC.
studies provide a deeper understanding of the critical role for WASF3 in facilitating increased invasion potential in cancer cells expressing mutant RAS and supports the idea that targeting WASF3 in metastatic cells overexpressing RAS may be used to suppress invasion and metastasis
Results implicate a contributory role of WAVE1 (zeige WASF1 Antikörper) and -3 to the metastatic phenotype of PC-3 (zeige PCSK1 Antikörper) cells through their interaction with the ARP2 (zeige ACTR2 Antikörper)/3 complex.
stabilization of WASF3 function occurs through its interaction with ATAD3A (zeige ATAD3A Antikörper) and GRP78 (zeige HSPA5 Antikörper), which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles
We show that WAVE3-mediated modulation of NFkappaB (zeige NFKB1 Antikörper) is required for invadopodia formation as well as MMP9 (zeige MMP9 Antikörper) expression and activity that are needed for cancer cells to degrade the ECM (zeige MMRN1 Antikörper)
WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization.
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
wiskott-Aldrich syndrome protein family member 3
, WASP family Verprolin-homologous protein 3
, WASP family protein member 3
, protein WAVE-3
, verprolin homology domain-containing protein 3