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anti-Human VEGFR2 Antikörper:
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anti-Rat (Rattus) VEGFR2 Antikörper:
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Human Monoclonal VEGFR2 Primary Antibody für FACS - ABIN4896290
den Dekker, Houtgraaf, Rowland, Ligtenberg, de Boer, de Jong, de Winter, den Heijer, Zijlstra, Serruys, Cheng, Duckers: Efficiency of statin treatment on EPC recruitment depends on baseline EPC titer and does not improve angiographic outcome in coronary artery disease patients treated with the Genous stent. in Cell transplantation 2015
Show all 49 Pubmed References
Mouse (Murine) Polyclonal VEGFR2 Primary Antibody für CyTOF, FACS - ABIN4899536
Hou, Nilchi, Li, Gangaraju, Jiang, Aylsworth, Monette, Slinn: Semaphorin3A elevates vascular permeability and contributes to cerebral ischemia-induced brain damage. in Scientific reports 2015
Show all 37 Pubmed References
Human Monoclonal VEGFR2 Primary Antibody für CyTOF, FACS - ABIN4899538
Riccioni, Diverio, Mariani, Buffolino, Riti, Saulle, Petrucci, Cedrone, Lo-Coco, Foà, Peschle, Testa: Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. in Stem cells (Dayton, Ohio) 2007
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Human Polyclonal VEGFR2 Primary Antibody für IHC (p), IP - ABIN152058
Rahimi, Dayanir, Lashkari: Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. in The Journal of biological chemistry 2000
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Human Monoclonal VEGFR2 Primary Antibody für IHC (fro) - ABIN3043643
Li, Huang, Chen, Chen, Xiong, Chen, You, Jin, Liang: Oriented immobilization of anti-CD34 antibody on titanium surface for self-endothelialization induction. in Journal of biomedical materials research. Part A 2010
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Human Monoclonal VEGFR2 Primary Antibody für FACS - ABIN4896282
Wang, Tang, Sun, Miao, Lv, Yang, Zhang, Zhang, Liu, Du, Gao, Yin, Ding, Deng: TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy. in Cell research 2012
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Hamster Polyclonal VEGFR2 Primary Antibody für ICC, IF - ABIN250774
Gluzman-Poltorak, Cohen, Shibuya, Neufeld: Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes. in The Journal of biological chemistry 2001
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Mouse (Murine) Monoclonal VEGFR2 Primary Antibody für IHC (f), IHC (fro) - ABIN2689505
Hanahan: Signaling vascular morphogenesis and maintenance. in Science (New York, N.Y.) 1997
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Human Monoclonal VEGFR2 Primary Antibody für FACS - ABIN4896286
De Biasi, Cerri, Bianchini, Gibellini, Persiani, Montanari, Luppi, Carbonelli, Zucchi, Bocchino, Zamparelli, Vancheri, Sgalla, Richeldi, Cossarizza: Levels of circulating endothelial cells are low in idiopathic pulmonary fibrosis and are further reduced by anti-fibrotic treatments. in BMC medicine 2015
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Human Polyclonal VEGFR2 Primary Antibody für FACS, IHC (p) - ABIN2180045
García Fernández, Sánchez Pérez, Sánchez Maldonado, García-Palencia, Naranjo Freixa, Palomo Yagüe, Flores: Iberian pig early pregnancy: vascular endothelial growth factor receptor system expression in the maternofetal interface in healthy and arresting conceptuses. in Theriogenology 2014
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Single nucleotide polymorphism of VEGFR2 is associated with relapse in gastroenteropancreatic neuroendocrine neoplasms.
Our data showed that ampelopsin inhibited angiogenesis with no cytotoxicity by suppressing both VEGFR2 signaling and HIF-1alpha (zeige HIF1A Antikörper) expression. These results suggest that Hovenia dulcis Thunb. and its active compound ampelopsin exhibit potent antiangiogenic activities and therefore could be valuable for the prevention and treatment of angiogenesis-related diseases including cancer.
Authors demonstrated that when VEGFR2 was inhibited, NRP-1 (zeige NELL1 Antikörper) appeared to regulate RAD51 (zeige RAD51 Antikörper) expression through the VEGFR2-independent ABL-1 (zeige ABL1 Antikörper) pathway, consequently regulating radiation sensitivity. In addition, the combined inhibition of VEGFR2 and NRP-1 (zeige NELL1 Antikörper) appears to sensitize cancer cells to radiation.
We found that depletion of FGD5 (zeige FGD5 Antikörper) in microvascular cells inhibited their migration towards a stable VEGFA (zeige VEGFA Antikörper) gradient. Furthermore, depletion of FGD5 (zeige FGD5 Antikörper) resulted in accelerated VEGFR2 degradation, which was reverted by lactacystin-mediated proteasomal inhibition. Our results thus suggest a mechanism whereby FGD5 (zeige FGD5 Antikörper) sustains VEGFA (zeige VEGFA Antikörper) signaling and endothelial cell chemotaxis via inhibition of proteasome-dependent VEGFR2 degradation.
ATG5 (zeige ATG5 Antikörper) and phospho-KDR expression was strongly associated with the density of vasculogenic mimicry in tumors and poor clinical outcome.
Increased expression of VEGFR2 correlated with differentiation.
DDA exhibits anti-angiogenic properties through suppressing VEGF-A (zeige VEGFA Antikörper) and VEGFR2 signaling
RCAN1.4 plays a novel role in regulating endothelial cell migration by establishing endothelial cell polarity in response to VEGF (zeige VEGFA Antikörper).
Anlotinib occupied the ATP-binding pocket of VEGFR2 tyrosine kinase (zeige TXK Antikörper).
the difference between the pro- (VEGF165a) and antiangiogenic (VEGF165b) VEGF (zeige VEGFA Antikörper) isoforms and its soluble receptors for severity of diabetic retinopathy, is reported.
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are required for the hematopoietic and cardiac fate divergence of mouse embryonic stem cells. Deletion of IP3Rs (IP3R (zeige ITPR1 Antikörper)-tKO (zeige MRPS12 Antikörper)) reduced Flk1+/PDGFRalpha- hematopoietic mesoderm, c-Kit (zeige KIT Antikörper)+/CD41+ hematopoietic progenitor cell population, and the colony-forming unit activity, but increased cardiac progenitor markers as well as cardiomyocytes.
Peli1 (zeige PELI1 Antikörper) is a proangiogenic molecule that acts downstream of VEGF (zeige VEGFA Antikörper)-Flk-1 and restores angiogenesis and enhances skin flap (zeige ALOX5AP Antikörper) survivability
KDR/Flk-1 expression was revealed in mononuclear cells of the necrotic area (macrophages and fibroblast cells). The distribution of KDR/Flk-1 remained practically unchanged with lengthening of the postinfarction period (more than 7 days).
By E10.5, both Sox7 (zeige SOX7 Antikörper) complete knockout and FLK1-specific deletion of Sox7 (zeige SOX7 Antikörper) lead to widespread vascular defects. In contrast, while SOX7 (zeige SOX7 Antikörper) is expressed in the earliest specified blood progenitors, the VAV (zeige VAV1 Antikörper)-specific deletion of Sox7 (zeige SOX7 Antikörper) does not affect the hematopoietic system. Together, our data reveal the unique role of SOX7 (zeige SOX7 Antikörper) in vasculogenesis and angiogenesis during embryonic development.
JAM-C (zeige JAM3 Antikörper) plays an important role in maintaining VEGR2 expression to promote retinal pigment epithelial cell survival under oxidative stress.
Genetic depletion experiments revealed that VEGFR2, but not VEGFR3 (zeige FLT4 Antikörper), is indispensable for maintenance of thyroid vascular integrity. Notably, blockade of VEGF-A (zeige VEGFA Antikörper) or VEGFR2 not only abrogated vascular remodeling but also inhibited follicular hypertrophy, which led to the reduction of thyroid weights during goitrogenesis.
Eriocalyxin B inhibited breast tumor angiogenesis by suppressing VEGFR-2 signaling.
transgenic mice may serve as valid models for the validation of novel therapies blocking the VEGFR-2 signaling pathway in hemangioma-like lesions and other vascular diseases
found that WT1 (zeige WT1 Antikörper) and KDR are co-expressed in Sertoli cells of the testes and somatic cells of embryonic ovaries. Furthermore, WT1 (zeige WT1 Antikörper) bound to the Kdr promoter in the chromatin of embryonic testes and ovaries. KDR signaling represses the testis-promoting gene Sox9 (zeige SOX9 Antikörper) in embryonic XX gonads
This is the first report demonstrating the spatiotemporal expression patterns of Flk1 and Flt1 (zeige FLT1 Antikörper) in the coronary vascular system during development and after MI; thus, this study suggests that these factors have distinct and important functions in coronary angiogenesis.
Here we demonstrate that VEGF (zeige VEGFA Antikörper)-165 mediates MSC (zeige MSC Antikörper) differentiation into ECs via VEGFR-2-dependent induction of Sox18 (zeige SOX18 Antikörper), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype
NOS (zeige NOS Antikörper) stimulation via PI3K, calpain proteases, and SIRT1 (zeige SIRT1 Antikörper)-dependent deacetylation downstream from VEGFR2 activation contributes to these vasodilator responses.
we analyzed the expression and cellular distribution of Flt-1(VEGFR-1 (zeige FLT1 Antikörper)) and Flk-1 (KDR/VEGFR-2)in newborn piglet brain
expression of FLK1, CD146 (zeige MCAM Antikörper) and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.
VEGF (zeige VEGFA Antikörper) supplementation at the late embryonic developmental stage might improve the developmental potential of both IVF (zeige SCN5A Antikörper) and somatic nuclear transfer preimplantation porcine embryos through its receptors.
The VEGFR2 mRNA was only upregulated in early glomerulogenesis, suggesting that VEGFR2 is important for the vascular growth.
increased placental expression of the VEGF receptor (zeige FLT1 Antikörper) system is associated with increased placental vascular density observed with the advancement of gestation in the pig
VEGF (zeige VEGFA Antikörper) ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.
VEGF (zeige VEGFA Antikörper)/Flk-1/Flt-1 (zeige FLT1 Antikörper) system is activated during myocardial ischemia reperfusion injury.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (zeige VEGFA Antikörper), pro-MMP-9 (zeige MMP9 Antikörper), MMP-2 (zeige MMP2 Antikörper), VEGFR-1 (zeige FLT1 Antikörper), VEGFR-2, and TIMP-1 (zeige TIMP1 Antikörper), which may contribute to the development of venous stenosis.
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
endothelial cells exposed to TGF-beta1 (zeige TGFB1 Antikörper) lose both tip and stalk cell identity, possibly mediated by loss of VEGFR2 signaling.
These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF (zeige VEGFA Antikörper) receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
Data suggest that galectin-1 (zeige LGALS1 Antikörper) and VEGFR-2 are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 (zeige LGALS1 Antikörper) binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 in luteal cells.
MMP-1 (zeige MMP1 Antikörper) promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 (zeige F2R Antikörper) and activation of NF-kappaB (zeige NFKB1 Antikörper)
Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 (zeige ARF1 Antikörper) to promote endothelial nitric-oxide synthase (zeige NOS3 Antikörper) activation and nitric oxide release from endothelial cells
VEGFR2 mRNA expression was higher at the mid and late luteal stages than at the early I and early II luteal stages, and VEGFR2 protein was higher at the mid and late luteal stages than at estrus (P<0.05)
Alterations in the expression of VEGF-A (zeige VEGFA Antikörper) and bFGF (zeige FGF2 Antikörper) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt (zeige AKT1 Antikörper) and endothelial nitric-oxide synthase (eNOS (zeige NOS3 Antikörper))
Placenta growth factor (zeige PGF Antikörper) expression is regulated by both VEGF (zeige VEGFA Antikörper) and hyperglycaemia via VEGFR-2.
These results indicate that VEGF-C (zeige VEGFC Antikörper)-induced MSC (zeige MSC Antikörper) osteogenesis is mediated through VEGFR2 and VEGFR3 (zeige FLT4 Antikörper), and followed the activation of the ERK (zeige MAPK1 Antikörper)/RUNX2 (zeige RUNX2 Antikörper) signaling pathway.
High VEGFR2 expression is associated with retinal neovascularization.
ghrelin (zeige GHRL Antikörper) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF (zeige VEGFA Antikörper) and VEGFR2 expression, inhibiting the plaque content of macrophages, and reducing MCP-1 (zeige CCL2 Antikörper) expression at an advanced stage of atherosclerosis in rabbits
Antenatal intratracheal VEGF (zeige VEGFA Antikörper) administration was associated with an increase in Flk-1 immunoreactivity.
Intronic Flk1 genetic enhancer element directs arterial-specific expression via RBPJ (zeige RBPJ Antikörper)-mediated venous repression.
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
fetal liver kinase 1
, fetal liver kinase-1
, protein-tyrosine kinase receptor Flk-1
, soluble VEGFR2
, tyrosine kinase growth factor receptor
, vascular endothelial growth factor receptor 2
, VEGF receptor-2
, kinase NYK
, protein-tyrosine kinase receptor flk-1
, soluble vascular endothelial growth factor receptor 2
, vascular endothelial growth factor receptor- 2
, vascular endothelial growth factor receptor-2
, vascular endothelial growth factor receptor-3
, FLK1 kinase insert domain receptor (VEGF receptor 2)
, FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
, kinase insert domain protein receptor
, flk-1 receptor
, protein-tyrosine kinase
, flk-1 type VEGF receptor
, tyrosine kinase receptor
, VEGF receptor-2/Flk-1
, VEGFR-2 homolog B
, fetal liver kinase 1b
, kinase insert domain receptor (a type III receptor tyrosine kinase), b
, kinase insert domain receptor-B
, protein-tyrosine kinase receptor flk-1b
, vascular endothelial growth factor receptor 2 homolog B