anti-VEGFA (VEGFA) Antikörper

Zebrafish Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. zebrafish macrophages can enhance Vegfa-driven tumour angiogenesis.

2. Knockdown of transmembrane protein 33 (tmem33) impairs multiple downstream effects of vascular endothelial growth factor (VEGF).

3. GDF6 promotes vascular stabilization by restraining vascular endothelial growth factor signaling.

4. Vegfaa role in the venous sprouting and spinal cord vascularization.

5. findings identify Vegfa as one of a select few known factors sufficient to activate adult cardiomyogenesis, while also illustrating how instructive factors for heart regeneration require spatiotemporal control for efficacy.

6. Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures

7. vascular endothelial growth factor and Hedgehog pathways have roles in the development of the superficial system of ocular vessel patterning in zebrafish

8. miR-9 modulation of neuronal VEGF-A controls brain angiogenesis in vivo.

9. Timelapse analysis of individual cardiomyocyte trajectories reveals misdirected cells in zebrafish pdgfra mutants, suggesting that PDGF signaling steers cardiomyocytes toward the midline during cardiac fusion. Intriguingly, the ligand pdgfaa is expressed in the endoderm medial to the pdgfra-expressing myocardial precursors.

10. This study demonstrates the involvement of VEGF signaling in regulating sustained liver injuries after acute alcohol exposure.

11. we determined that radial glia control this process via the Vegf decoy receptor sFlt1: sflt1 mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression rescues it. Genetic mosaic analyses show that sFlt1 function in trunk endothelial cells can limit their over-sprouting.

12. High VEGFA expression is associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.

13. Rspo1 is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC specification: Wnt16/DeltaC/DeltaD and Vegfa/Tgfbeta1

14. Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.

15. low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.

16. altering the amount of VEGF signaling in endothelial cells by stimulating them with different VEGF concentrations triggered distinct and mutually exclusive dynamic Ca(2+) signaling responses that correlated with different cellular behaviors.

17. Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether downregulate the expression of VEGF and VEGFR, and simultaneously regulates VEGF signaling pathway to prevent angiogenesis.

18. noncanonical function of tars regulates vascular development presumably by modulating the expression of vegfa

19. Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.

20. The translation initiation factor eIF3i up-regulates VEGF-A, accelerates cell proliferation, and promotes angiogenesis in embryonic development.

Xenopus laevis Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. Etv6, positively regulates vegfa expression during Xenopus blood stem cell development through multiple transcriptional inputs. In agreement with its established repressive functions, Etv6 directly inhibits expression of the repressor foxo3, to prevent Foxo3 from binding to and repressing the vegfa promoter.

2. VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.

3. sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.

4. VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.

5. Functional roles of VEGF122 and VEGF170 during development were examined.

6. increased VEGF(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis

Cow (Bovine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

2. Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.

3. Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.

4. Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).

5. Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha and ATF6 arms of the unfolded protein response compared with untreated cells.

6. Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.

7. VEGF supports germ cell survival and sperm production in bulls.

8. analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle

9. VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter

10. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

11. Advanced glycation end products increase, through a protein kinase C-dependent pathway, expression in reignal endothelial cells; inhibited by gliclazide.

12. VEGF signaling is regulated by atrial natriuretic peptide, which preserves endothelial cell tight junction functional morphology

13. Airline pilots are good candidates to see if mutation in the VEGF promoter are responsible for some cases of amyotrophic lateral sclerosis.

14. role in dowregulating Flk-1/KDR involves Cbl-mediated ubiquitination

15. interaction with glucose-6-phosphate dehydrogenase is involved in angiogenesis

16. Results suggest that leptin might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes.

17. Shear stress and VEGF converge at the membrane receptor Flk-1 and these stimuli share the Flk-1/Cbl/Akt pathway in activating IKK activation.

18. Tumor cells activate confluent, quiescent EC, promoting survival, phenotypic, and gene expression changes. Of importance, VEGF antagonism converts tumor-conditioned medium from protective to endothelial cell-damaging effects.

19. MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression

20. placenta growth factor expression is regulated by both VEGF and hyperglycaemia via VEGFR-2

Human Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. There was no important difference of allele distribution of the - 2578 A/C (P = 0.7) and + 936 C/T (P = 0.5) polymorphisms among endometriosis cases and controls.

2. a novel mechanism of TUG1 in RCC tumorigenesis

3. Critical ischemia is associated with higher VEGF-A, MMP-9, TIMP-1, and TIMP-2 plasma concentrations than in the case of intermittent claudication

4. VEGF-A expression values in thyroid carcinoma did not associate with tumor necrosis degree (p=1.000).

5. Combining genetic effect in recurrent spontaneous abortion of vascular endothelial growth factor, endothelial nitric oxide synthase and thrombin-activatable fibrinolysis inhibitor genetic polymorphisms.

6. We identified BMAL1 as a potential marker and functional player in resistance to clinically-in-use VEGFA-neutralizing antibody (bevacizumab) in preclinical, clinical and cellular mechanistic studies of colorectal cancer.

7. influence of +SNP 936 on mRNA stability may be responsible for regulation of VEGF plasma levels

8. VEGF promoted vasculogenic mimicry (VM) formation by the PI3K signal transduction pathway, indicating a molecular mechanism which may be used to develop new therapeutic targets for the clinical treatment of Choroidal Melanoma.

9. High serum VEGF levels are associated with diabetic nephropathy.

10. Direct interaction and binding between VEGF and polyphenol molecules acting as inhibitors of the signaling of VEGFR2 has been measured for the first time. The binding between VEGF and EGCG seemed to be based on hydrophobic interactions and caused a change in the secondary structure of the protein

11. This study concluded that miR-150-5p may function as a tumor suppressor in CRC, and miR-150-5p/VEGFA axis may be a potential therapeutic target candidate in CRC treatment.

12. Results provide evidence that VEGF 936-C allele is associated with poor prognosis, but not risk of gastric cancer.

13. The present findings indicate that 1405C/G polymorphism of the VEGF gene increases the risk of rosacea.

14. CCAT2/miR-200b/vascular endothelial growth factor (VEGF) axis plays important regulating effect in OSA through the PI3K/Akt and AMPK pathways

15. VEGF 3'-UTR polymorphisms may be utilized as biomarkers for the detection of recurrent pregnancy loss risk and prevention.

16. Results provide evidence that BK upregulates VEGF expression and promotes cervical cancer angiogenesis through B2R.

17. Data found that VEGF expression in cutaneous neurofibroma is regulated by AR which bound directly to the VEGFA promoter to initiate its transcription.

18. VEGFA amplification/increased gene copy number and VEGFA mRNA expression occur in TFEB-amplified renal cell carcinoma, but also in a subset of t(6;11) renal cell carcinoma demonstrating aggressive behavior, and in unamplified conventional t(6;11) renal cell carcinoma

19. Plerixafor + bevacizumab was well tolerated in HGG patients. Plerixafor distributed to both the CSF and brain tumor tissue, and treatment was associated with biomarker changes consistent with VEGF and CXCR4 inhibition.

20. A new SNP in 3'UTR of VEGFA gene (rs1377053612, A>C) was significantly associated with the presence of pigmented subtype (A/C vs A/A, two-sided Fisher exact test P = 0.028). Also in this group type, having a family member with periorbital hyperpigmentation was more prevalent in subject with A/C genotype than AA (43% vs 13.5%, two-sided Fisher exact test P = 0.024).

Mouse (Murine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. To investigate the role of VEGF and the mechanism underlying microvascular damage in RBI, wild type mice, and transgenic mice overexpressing VEGF derived from astrocytes, were separately and randomly exposed to whole-brain or sham irradiation. damage to the BBB and histopathology in the transgenic mice were worse than those of wild type mice in the irradiated groups.

2. Alternative splicing of VEGF-A to pro-angiogenic VEGF165 may contribute to the development of atherosclerosis.

3. These findings provided insights on VEGF-A/PlGF heterodimer function, which was able to rescue neovascularization and vascular leakage.

4. Wt1 activates Srpk1 and Srsf1 and induces expression of angiogenic VEGF isoforms in tumor endothelium.

5. Del-1 is not a major determinant of prion pathogenesis.

6. Study demonstrates that adipose-specific VEGF repression can lead to antiobesity activity through adipose browning.

7. This is the first study to show that corin is a key regulator of bone development by modulation of VEGF-A expression.

8. VEGF as a new player in Epo induction and perivascular Gli1(+)SMA(+)PDGFRbeta(+) cells as a previously unrecognized EPC reservoir that could be harnessed for augmenting Epo synthesis in circumstances such as chronic kidney disease where production by canonical EPCs is compromised.

9. Thrombin induced VEGF release from astrocytes require p44/42. Thrombin induced VEGF release from astrocytes is reduced in PAR-1 knockout mice. Thrombin induced p44/42 activation in astrocytes is blocked in PAR-1 knockout mice.

10. PDGF-BB co-expression prevents VEGF-induced aberrant angiogenesis by modulating VEGF-R2 signaling and endothelial proliferation, thereby limiting the degree of circumferential enlargement and enabling efficient completion of vascular splitting into normal capillary networks despite high VEGF doses.

11. FOXO1 directly regulates VEGFA expression, promoting normal angiogenesis during wound healing.

12. Increased VEGF165b expression in macrophages induces an antiangiogenic M1-like phenotype that directly impairs angiogenesis. VEGFR1 inhibition by VEGF165b results in S100A8/S100A9-mediated calcium influx to induce an M1-like phenotype that impairs ischemic muscle revascularization and perfusion recovery.

13. The found of this study showed that interneurons reach the dorsal cortex at mid phases of corticogenesis despite an aberrant vascular network. Instead, endothelial ablation of Vegfa alters cortical interneuron numbers, their intracortical distribution and spatial proximity to blood vessels

14. The macrophage infiltration simulated through conditioned medium (CM) seems to be a similar environment to an abnormally enlarged eWAT. We have evidenced that HIF-1a plays a regulatory role in the expression of Vegfa and Ucp2 in CM. Finally, the inhibition of the mTOR pathway prevented the HIF-1alpha activation induced by CM.

15. Hepatic stellate cells were regulated by TGF-beta1 signaling to express Jagged1 and VEGFA, which were associated with hepatic angiogenesis.

16. VEGF aggravated blood-brain barrier disruption after cerebral ischemia/reperfusion-induced injury probably by increasing LOC102640519 and HOXC13 through inhibition of ZO-1, Occludin and Claudin-5.

17. A combination of anti-VEGF and anti-PD-L1 therapies can be an effective treatment strategy in patients with SCLC.

18. VEGF accelerates compensatory lung growth in mice by increasing the alveolar units in a process medicated by VEGFR2 and EGF

19. findings demonstrate that COX-2 activity is important in the recruitment of VEGF-secreting Ly6C(high) monocytes, which are involved in VILI pathogenesis, and indicate that the suppression of COX-2 activity might be a useful strategy in mitigating ventilator-induced lung injury.

20. these are the first studies to assess and compare "off-target" host secretory effects of VEGF and PD-1 pathway inhibition that occur independent of tumor stage or tumor response to therapy.

Pig (Porcine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. MMP9 and VEGF, but not MMP13 or FGF23 may have roles in bone lesions in the hypovitaminosis D kyphotic pig model

2. It regulates endometrial remodeling in the porcine endometrial tissues during follicular and luteal phase.

3. It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.

4. results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility

5. Here we demonstrate that VEGF-165 mediates MSC differentiation into ECs via VEGFR-2-dependent induction of Sox18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.

6. VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.

7. VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.

8. findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch signaling.

9. interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells

10. Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha.

11. data shows that members of the VEGF-VEGFR system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy

12. cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation

13. The mRNA for VEGFA was expressed in early developing and in maturing glomeruli.

14. Data show that subventricular zone neural stem cells express VEGF and all VEGF splice variants, VEGFR1, VEGFR2 and Neuropilin-1 and -2 mRNAs.

15. The earlier increase in VEGF protein and mRNA expression in the Meishan versus the Yorkshire conceptus may explain the previously reported increased vascularity and increased placental efficiency of this breed compared the Yorkshire breed.

16. Contrast media did not affect bone marrow cell viability/VEGF secretion.

17. VEGF upregulation in the proliferative zone after ischemic damage may play a role in stimulating vascular invasion and granulation tissue formation in the necrotic hypertrophic zone of the epiphyseal cartilage

18. Data demonstrate that lipopolysaccharides evoke a heat shock response, with an increase heat shock proteins 70 and Hsp32) and of VEGF, a specific endothelial cell growth factor.

19. Vascular endothelial growth factor (VEGF) plays an important role in the thecal angiogenesis during follicular development.

20. number of preovulatory follicles and the capillary density in the theca interna increased significantly in the ovaries injected with VEGF gene

Horse (Equine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion

2. TNF may up-regulate VEGF and stimulate angiogenesis in the mare early corpus luteum.

Guinea Pig Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. After acoustic trauma, vascular endothelial growth factor was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.

2. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

Rabbit Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. These results demonstrated that administration of anti-VEGF in the anterior chamber of rabbit affects endothelial cell survival by inducing apoptosis through alteration of NGF pathway.

2. MiR-145 silencing promotes bone repair of avascular necrosis of femoral head (ANFH) via upregulating VEGF, bFGF and inhibiting the bone cells apoptosis through Wnt/beta-catenin pathway

3. ghrelin can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 expression, inhibiting the plaque content of macrophages, and reducing MCP-1 expression at an advanced stage of atherosclerosis in rabbits

4. VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.

5. correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV) and expression of VEGF and MVD in tumor tissue

6. Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.

7. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

8. Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.

9. VEGF expression peaked at 8 weeks after meniscus transplantation

10. Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF).

11. VEGF induces TGF-beta1 expression and myofibroblast transformation after glaucoma surgery.

12. The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis

13. The overexpression of VEGF increased tumor growth and vascularization, favored cyst formation, and reduced tumor necrosis.

14. VEGF may play a role in the blood-aqueous barrier dysfunction after retinal laser photocoagulation.

15. In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF and TNFalpha.

16. It appears that VEGF modulates angiogenesis and osteogenesis in shockwave-promoted bone healing in rabbits.

17. Transplantation of mononuclear bone marrow cells promotes the expression of VEGF in acute liver injury.

18. The down-regulation of VEGF may play a critical role in the disease process of osteonecrosis.

19. Vitreous VEGF levels increase in positive correlation with plasma VEGF during pregnancy

20. Antenatal intratracheal VEGF administration was associated with an increase in Flk-1 immunoreactivity.

Rhesus Monkey Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. Data suggest that microRNA-126 plays role in diabetic retinopathy; here, choroid-retinal endothelial cells exposed to high glucose exhibit down-regulation of microRNA-126 and up-regulation of VEGFA and PIK3R2; overexpression of microRNA-126 down-regulates expression of VEGFA and PIK3R2. (VEGFA = vascular endothelial growth factor A; PIK3R2 = class Ia phosphoinositol-3 kinase regulatory subunit 2)

2. VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.

3. Evidence of non-AUG translation initiation in humans.

4. Evidence of non-AUG translation initiation in humans.

5. These findings suggest that FBLN5 may interfere with choroidal neovascularization by downregulating VEGF, CXCR4, and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.

6. Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.

7. Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.

8. A functional network involving VEGF, IGF2, and MMP9 in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.