anti-VEGFA (VEGFA) Antikörper

Zebrafish Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. zebrafish macrophages can enhance Vegfa-driven tumour angiogenesis.

2. Knockdown of transmembrane protein 33 (tmem33) impairs multiple downstream effects of vascular endothelial growth factor (VEGF).

3. GDF6 promotes vascular stabilization by restraining vascular endothelial growth factor signaling.

4. Vegfaa role in the venous sprouting and spinal cord vascularization.

5. findings identify Vegfa as one of a select few known factors sufficient to activate adult cardiomyogenesis, while also illustrating how instructive factors for heart regeneration require spatiotemporal control for efficacy.

6. Vegfa signaling governs the formation of diverse arteries/veins by distinct cellular mechanisms in vertebrate vasculatures

7. vascular endothelial growth factor and Hedgehog pathways have roles in the development of the superficial system of ocular vessel patterning in zebrafish

8. miR-9 modulation of neuronal VEGF-A controls brain angiogenesis in vivo.

9. Timelapse analysis of individual cardiomyocyte trajectories reveals misdirected cells in zebrafish pdgfra mutants, suggesting that PDGF signaling steers cardiomyocytes toward the midline during cardiac fusion. Intriguingly, the ligand pdgfaa is expressed in the endoderm medial to the pdgfra-expressing myocardial precursors.

10. This study demonstrates the involvement of VEGF signaling in regulating sustained liver injuries after acute alcohol exposure.

11. we determined that radial glia control this process via the Vegf decoy receptor sFlt1: sflt1 mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression rescues it. Genetic mosaic analyses show that sFlt1 function in trunk endothelial cells can limit their over-sprouting.

12. High VEGFA expression is associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors.

13. Rspo1 is required for hematopoietic stem cell specification through control of parallel signaling pathways controlling HSC specification: Wnt16/DeltaC/DeltaD and Vegfa/Tgfbeta1

14. Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.

15. low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.

16. altering the amount of VEGF signaling in endothelial cells by stimulating them with different VEGF concentrations triggered distinct and mutually exclusive dynamic Ca(2+) signaling responses that correlated with different cellular behaviors.

17. Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether downregulate the expression of VEGF and VEGFR, and simultaneously regulates VEGF signaling pathway to prevent angiogenesis.

18. noncanonical function of tars regulates vascular development presumably by modulating the expression of vegfa

19. Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.

20. The translation initiation factor eIF3i up-regulates VEGF-A, accelerates cell proliferation, and promotes angiogenesis in embryonic development.

Xenopus laevis Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. Etv6, positively regulates vegfa expression during Xenopus blood stem cell development through multiple transcriptional inputs. In agreement with its established repressive functions, Etv6 directly inhibits expression of the repressor foxo3, to prevent Foxo3 from binding to and repressing the vegfa promoter.

2. VEGFA produced in the somites is required to initiate adult haemangioblast programming in the adjacent dorsal lateral plate mesoderm.

3. sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and hematopoietic stem cell programs in the dorsal aorta.

4. VEGF induces stromal cell migration or recruitment that are required for blood vessel formation.

5. Functional roles of VEGF122 and VEGF170 during development were examined.

6. increased VEGF(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis

Cow (Bovine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

2. Studied the effect of cyclic uniaxial stretch (20%, 1 Hz), with and without the stimulation of vascular endothelial growth factor (VEGF), on sprouting angiogenesis by employing a stretchable three-dimensional cell culture model.

3. Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension.

4. Data indicate that superoxide dismutase (SOD) inhibited high glucose (HG)-induced expression of uPAR and VEGF in bovine retinal microvascular endothelial cell (REC).

5. Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha and ATF6 arms of the unfolded protein response compared with untreated cells.

6. Microvascular endothelial cells are more susceptible than aortic cells to advanced glycation end products-enhanced permeability and that AGE-enhanced permeability is dependent on VEGF expression induced by reactive oxygen species.

7. VEGF supports germ cell survival and sperm production in bulls.

8. analysis of polymorphisms of bovine VEGF gene and their associations with growth traits in Chinese cattle

9. VEGF mRNA expression at estrus was higher than at the early I, early II and late luteal stages (P<0.05), whereas VEGF protein content was greatest at the early I luteal stage and decreased thereafter

10. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

11. Advanced glycation end products increase, through a protein kinase C-dependent pathway, expression in reignal endothelial cells; inhibited by gliclazide.

12. VEGF signaling is regulated by atrial natriuretic peptide, which preserves endothelial cell tight junction functional morphology

13. Airline pilots are good candidates to see if mutation in the VEGF promoter are responsible for some cases of amyotrophic lateral sclerosis.

14. role in dowregulating Flk-1/KDR involves Cbl-mediated ubiquitination

15. interaction with glucose-6-phosphate dehydrogenase is involved in angiogenesis

16. Results suggest that leptin might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes.

17. Shear stress and VEGF converge at the membrane receptor Flk-1 and these stimuli share the Flk-1/Cbl/Akt pathway in activating IKK activation.

18. Tumor cells activate confluent, quiescent EC, promoting survival, phenotypic, and gene expression changes. Of importance, VEGF antagonism converts tumor-conditioned medium from protective to endothelial cell-damaging effects.

19. MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression

20. placenta growth factor expression is regulated by both VEGF and hyperglycaemia via VEGFR-2

Human Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. VEGF, CD34, and CD44 immunohistochemical expression was evaluated in the interproximal biopsies of marginal peri-implant tissue and correlated with the clinical parameters. Peri-implantitis patients had significantly higher levels of VEGF, CD34, and CD44 expression compared to the other groups. for peri-implantitis

2. Promote airway hyperresponsiveness through production of VEGFA

3. Down-regulation of HIF-1alpha can inhibit the proliferation, migration, and invasion of gastric cancer possibly by inhibiting PI3K/AKT pathway and VEGF expression

4. ShRNA targeting HIF-1alpha can effectively silence the expression of HIF-1alpha, reduce the expression of VEGF and up-regulate the expression of PEDF in human corneal epithelial cells

5. High VEGFA expression is associated with acute myeloid leukemia.

6. In vitro mechanism study revealed that the advanced glycation end products (AGEs) significantly increased the expression of Cyr61 in retinal pigment epithelial (RPE) cells, mimicking the effects of diabetes. In turn, the increased Cyr61 enhanced VEGF expression through FAK and PI3K/Akt pathways.

7. Results show that the expression levels of vascular endothelial growth factor A (VEGFA), angiopoietin-2 (ANGPT2), and tissue plasminogen activator (PLAT) were suppressed in ADAM9-silenced cells, which in turn leads to decreases in angiogenesis, vascular remodeling, and tumor growth in vivo.

8. Followed by an increase in hypoxia-inducible factor-1alpha (HIF-1alpha) protein and VEGF mRNA expression.

9. The inhibition of FLT1 ectodomain cleavage by VEGF-A is dependent neither on receptor activation nor on internalization.

10. LINGO1 might be a positive primary glioblastoma prognostic gene and C7orf31 and VEGFA might be negative prognosticators.

11. Fluorescent VEGF-A isoforms have been evaluated for their ability to discriminate between VEGFR2 and NRP1 in real-time ligand binding studies in live cells. VEGF165a, VEGF121a, and VEGF165b were single-site labeled with tetramethylrhodamine (TMR). VEGFR2 and NRP1 have markedly distinct kinetic profiles binding VEGF165a-TMR.

12. Polymorphisms of the VEGF gene rs699947 locus may contribute to an increased risk for colonic Crohn's disease (CD) among Chinese patients, but may play a protective role in patients with ileal lesion. Individuals carrying the TT genotype for VEGF rs3025039 locus may be less susceptible to non-stricturing and non-penetrating CD.

13. VEGF165b cannot be treated as a prognostic factor. VEGF receptors correlated with selected clinicopathological data of malignant tumors, indicating their possible role as a prognostic marker. The balance of VEGF isoforms have a limited influence on the development of parotid glands tumors.

14. VEGFA played an important role in hypoxia-induced vasculogenic mimicry through regulating epithelial-mesenchymal transition and stemness, which may eventually fuel the migration and invasion of salivary adenoid cystic carcinoma.

15. Results show that individual polymorphisms of VEGF do not appear to contribute to prostate cancer. However, a combination of risky alleles of the studied polymorphisms significantly increases the risk of prostate cancer in Slovak patients.

16. revascularization and progression of pancreatic neuroendocrine tumors (PNETs) under extended vascular-endothelial growth factor A (VEGFA) blockade are dependent on periostin (POSTN), a matricellular protein expressed by stromal cells.

17. Metastatic breast cancer patients with elevated levels of sVEGF have significantly worse clinical outcome. This finding supports the biological role of VEGF in breast cancer.

18. The results of the present investigation, VEGF serum levels are elevated in association with cognitive impairment in AD patients; show a significant severity-related increase in ApoE4 carriers.

19. HIF1A and VEGF could regulate each other in peritoneal mesothelial cell in the mediation of miR-17-5p and 3'UTR, indicating HIF1A and VEGF might regulate each other through competing endogenous RNA mechanism in the development of peritoneal fibrosis.

20. Report association between VEGF and Clusterin up-regulation and neurological symptoms of patients with high-grade carotid artery stenosis.

Mouse (Murine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. findings demonstrate that COX-2 activity is important in the recruitment of VEGF-secreting Ly6C(high) monocytes, which are involved in VILI pathogenesis, and indicate that the suppression of COX-2 activity might be a useful strategy in mitigating ventilator-induced lung injury.

2. these are the first studies to assess and compare "off-target" host secretory effects of VEGF and PD-1 pathway inhibition that occur independent of tumor stage or tumor response to therapy.

3. The present study found that increased choroidal neovascularisation severity together with higher expression of Cyr61 and VEGF in diabetes mice compared with control mice.

4. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs)..DP cells treated with MSC-EVs displayed increased expression and secretion of VEGF and IGF-1.

5. Herein, we reported a novel dual-targeting therapy for glioblastoma through simultaneous blockade of VEGF and CD47 signaling.

6. Conditional knock-down of Vegf attenuates induced osteoarthritis.

7. revascularization and progression of pancreatic neuroendocrine tumors (PNETs) under extended vascular-endothelial growth factor A (VEGFA) blockade are dependent on periostin (POSTN), a matricellular protein expressed by stromal cells.

8. Study showed that administering vascular endothelial growth factor concurrently increased the expression of disintegrin and metalloproteinase domain-containing protein 10 and decreased the expression of beta-site APP cleaving enzyme 1, which contributes to the enhanced clearance of amyloid-beta in vivo.

9. These results suggest that retinoic acids produced by Aldh1a1 in the neural retina directs dorsal choroidal vascular development via Sox9 upregulation in the dorsal retinal pigment epithelial cells to enhance retinal pigment epithelial-derived VEGF secretion.

10. FENDRR could promote the apoptosis of FENDRR could promote the apoptosis of human brain microvascular endothelial cells via miR-126 regulating VEGFA in hypertensive intracerebral hemorrhage via miR-126 regulating VEGFA in hypertensive intracerebral hemorrhage

11. Letter: PlGF in promotes skin angiogenesis independently of VEGF-A.

12. Infection with enterotoxins-producing Clostridium difficile strains but not with a TcdA(-)TcdB(-) isogenic mutant increases colonic vascular permeability in mice and elevates vascular endothelial growth factor A (VEGF-A). Both neutralization of VEGF-A and inhibition of its signalling pathway attenuated Clostridium difficile infection pathogenesis in vivo.

13. When miR27a expression was depleted by miR27a inhibitor, the protective effect of betaelemene on RNV was eliminated. The present study demonstrated that belemene reduced RNV in mouse oxygen-induced retinopathy (OIR) models via miR27a upregulation, leading to reduced VEGF expression.

14. the results of immunofluorescence staining of hepatic myeloid cells and detection of vascular growth factor A (VEGFA) in blood and liver suggested that the reduced degeneration of collagen in liver sinusoids was associated with decreased myeloid cell adhesion and the downregulation of VEGFA in the liver.

15. repressed Dll4-Notch1 signaling pathway but not downregulation of VEGF-A expression are responsible for hyperoxia induced pervasive vessel regression.

16. Here the authors have demonstrated that TGF-beta/Smad signaling plays an important role in Laser-induced choroidal neovascularization formation through down-regulation of VEGF and TNF-alpha expressions.

17. renal ischemia/reperfusion (I/R) induced miR-377 expression, which upregulated VEGF expression to attenuate renal I/R-induced oxidative stress and inflammation, and finally ameliorated renal dysfunction.

18. Mice exposed to treadmill exercise after cerebral ischemia showed a significant up-regulation in expression of VEGF compared to non-exercised animals.

19. At this late stage, glomerular VEGF and fibrosis-related-gene expression was also significantly increased compared with nondiabetic db/m mice. These results suggest that LRG1 plays a pivotal role in the initial development of diabetic nephropathy by promoting abnormal angiogenesis, thereby suggesting that LRG1 is a potential preemptive therapeutic target of diabetic nephropathy.

20. uterine endothelial cells promoted miR138 to induce exosomemediated inflammation and apoptosis in Ems through the VEGF/NFkappaB signaling pathway.

Pig (Porcine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. It regulates endometrial remodeling in the porcine endometrial tissues during follicular and luteal phase.

2. It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.

3. results are consistent with a participation of (VEFG) in the regulation of the dynamics of oviductal fluid secretion and the oviduct contractibility

4. Here we demonstrate that VEGF-165 mediates MSC differentiation into ECs via VEGFR-2-dependent induction of Sox18, which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype.

5. VEGF was significantly downregulated 7 days after cryotherapy of the sclera and stayed at that level until day 14. It returned to baseline by day 21.

6. VEGF production, blood vessel network and follicle remodeling are impaired by the antiprogesterone RU486.

7. findings suggest that the augmented neovascular response seen with VEGF administration was through the VEGF-induced upregulation of Notch signaling.

8. interleukin-1beta-induced vascular endothelial growth factor in airway smooth muscle cells

9. Upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1alpha.

10. data shows that members of the VEGF-VEGFR system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy

11. cardiac-specific and hypoxia-induced coexpression of VEGF and Ang1 improves the perfusion and function of porcine MI heart through the induction of angiogenesis and cardiomyocyte proliferation

12. The mRNA for VEGFA was expressed in early developing and in maturing glomeruli.

13. Data show that subventricular zone neural stem cells express VEGF and all VEGF splice variants, VEGFR1, VEGFR2 and Neuropilin-1 and -2 mRNAs.

14. The earlier increase in VEGF protein and mRNA expression in the Meishan versus the Yorkshire conceptus may explain the previously reported increased vascularity and increased placental efficiency of this breed compared the Yorkshire breed.

15. Contrast media did not affect bone marrow cell viability/VEGF secretion.

16. VEGF upregulation in the proliferative zone after ischemic damage may play a role in stimulating vascular invasion and granulation tissue formation in the necrotic hypertrophic zone of the epiphyseal cartilage

17. Data demonstrate that lipopolysaccharides evoke a heat shock response, with an increase heat shock proteins 70 and Hsp32) and of VEGF, a specific endothelial cell growth factor.

18. Vascular endothelial growth factor (VEGF) plays an important role in the thecal angiogenesis during follicular development.

19. number of preovulatory follicles and the capillary density in the theca interna increased significantly in the ovaries injected with VEGF gene

20. our study revealed the presence of VEGF in endothelial and smooth muscle cells of vascular subovarian plexus arteries

Horse (Equine) Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion

2. TNF may up-regulate VEGF and stimulate angiogenesis in the mare early corpus luteum.

Guinea Pig Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. After acoustic trauma, vascular endothelial growth factor was up-regulated both in the cochlea and vestibule. Expression in both structures suggests a reparative role with potentially therapeutic implications.

2. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

Rabbit Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. MiR-145 silencing promotes bone repair of avascular necrosis of femoral head (ANFH) via upregulating VEGF, bFGF and inhibiting the bone cells apoptosis through Wnt/beta-catenin pathway

2. ghrelin can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 expression, inhibiting the plaque content of macrophages, and reducing MCP-1 expression at an advanced stage of atherosclerosis in rabbits

3. VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.

4. correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV) and expression of VEGF and MVD in tumor tissue

5. Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.

6. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

7. Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.

8. VEGF expression peaked at 8 weeks after meniscus transplantation

9. Studied the biocompatibility and neovascularization of the PLGA nanospheres wrapped with vascular endothelial growth factor (VEGF).

10. VEGF induces TGF-beta1 expression and myofibroblast transformation after glaucoma surgery.

11. The results of this study are promising concerning the role of VEGF as a diagnostic marker in moderate osteoarthritis

12. The overexpression of VEGF increased tumor growth and vascularization, favored cyst formation, and reduced tumor necrosis.

13. VEGF may play a role in the blood-aqueous barrier dysfunction after retinal laser photocoagulation.

14. In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF and TNFalpha.

15. It appears that VEGF modulates angiogenesis and osteogenesis in shockwave-promoted bone healing in rabbits.

16. Transplantation of mononuclear bone marrow cells promotes the expression of VEGF in acute liver injury.

17. The down-regulation of VEGF may play a critical role in the disease process of osteonecrosis.

18. Vitreous VEGF levels increase in positive correlation with plasma VEGF during pregnancy

19. Antenatal intratracheal VEGF administration was associated with an increase in Flk-1 immunoreactivity.

20. VEGF is expressed at different times and locations during bone healing.

Rhesus Monkey Vascular Endothelial Growth Factor A (VEGFA) Interaktionspartner

1. Data suggest that microRNA-126 plays role in diabetic retinopathy; here, choroid-retinal endothelial cells exposed to high glucose exhibit down-regulation of microRNA-126 and up-regulation of VEGFA and PIK3R2; overexpression of microRNA-126 down-regulates expression of VEGFA and PIK3R2. (VEGFA = vascular endothelial growth factor A; PIK3R2 = class Ia phosphoinositol-3 kinase regulatory subunit 2)

2. VEGF plays an important role in choroid-retinal endothelial cell proliferation and tube formation.

3. Evidence of non-AUG translation initiation in humans.

4. Evidence of non-AUG translation initiation in humans.

5. These findings suggest that FBLN5 may interfere with choroidal neovascularization by downregulating VEGF, CXCR4, and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.

6. Apelin may play a role in the development of central retinal vein occlusion (CRVO). Apelin has a unique upstream signaling pathway, independent of the VEGF pathway.

7. Dll4 play an important role in choroidal neovascularization (CNV) angiogenesis, which appears to be regulated by HIF-1alpha and VEGF during the progression of CNV under hypoxic conditions.

8. A functional network involving VEGF, IGF2, and MMP9 in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.