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Isoform b of DDR1 (zeige DDR1 Proteine) is responsible for collagen I-induced up-regulation of N-cadherin (zeige CDH2 Proteine) and tyrosine 513 of DDR1b is necessary.
NIC (zeige NCSTN Proteine) exacerbated AZA-dependent injury via augmenting p66shc transcription. While RES suppressed NIC (zeige NCSTN Proteine)+AZA-mediated injury, -surprisingly-it further enhanced activity of the p66shc promoter. RES protected cells via the cytoplasmic p66shc/Nrf2 (zeige GABPA Proteine)/heme oxygenase-1 (HO-1 (zeige HMOX1 Proteine)) axis
The results show that the interaction between STS-1 (zeige STS1 Proteine) and ShcA is regulated in response to EGF receptor (zeige EGFR Proteine) activation.
Nox4 (zeige NOX4 Proteine)-derived H2O2 in part activates Nox2 (zeige CYBB Proteine) to increase mitochondrial ROS (zeige ROS1 Proteine) via pSer36-p66Shc, thereby enhancing VEGFR2 (zeige KDR Proteine) signaling and angiogenesis in endothelial cells.
Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (zeige POLD3 Proteine)CA (p66) activation invol (zeige SIGLEC1 Proteine)ving Ser(139) and a motif surroun (zeige SIGLEC1 Proteine)ding Ser(213).
Data identify, for the first time, a novel non-canonical dynamic mode of interaction between Met and the p66 (zeige POLD3 Proteine) protein isoform of Shc and its effects on rewiring binding effector complexes according to the activation state of the receptor.
regulates the alternative splicing of XAF1 (zeige XAF1 Proteine) in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death
The silence of p66(Shc) in HCT8 cells reduced the proliferation and accelerated the apoptosis, in addition, the expression of pro-apoptotic proteins caspase-3 (zeige CASP3 Proteine), caspase-9 (zeige CASP9 Proteine), Bax (zeige BAX Proteine) was enhanced and the expression of anti-apoptotic protein Bcl-2 (zeige BCL2 Proteine) was declined.
In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin (zeige INS Proteine) resistance.
Data suggest SHC1 (SH2 domain protein C1) expression down-regulates epithelial-mesenchymal transition by repressing TGFB (zeige TGFB1 Proteine)-induced SMAD2 (zeige SMAD2 Proteine)/3 activation through differential partitioning of receptors at cell surface of mammocytes/keratinocytes.
Data show that adaptor protein Shc is required for angiogenesis in zebrafish (accession number LOC563639), mice, and human vascular endothelial cell-culture models.
ShcA is required for Wnt-5a (zeige WNT5A Proteine)/Ror2 (zeige ROR2 Proteine) mediated upregulation of xPAPC (zeige PCDH8 Proteine), which demonstrates the functional relevance of this interaction.
Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase (zeige CAT Proteine).
p66shc, but not p53 (zeige TP53 Proteine), is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest.
p66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos
These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling.
P66Shc, a key regulator of metabolism and mitochondrial ROS (zeige ROS1 Proteine) production, is dysregulated by mouse embryo culture
The results indicate that Shc proteins should be considered as potential targets for developing interventions to mitigate weight gain on high-fat diet by stimulating energy expenditure.
Hyperglycemia and elevated free fatty acids in the diabetic milieu recruit p66Shc to upregulate endothelial miR (zeige MLXIP Proteine)-34a via an oxidant-sensitive mechanism, which leads to endothelial dysfunction by targeting Sirt1 (zeige SIRT1 Proteine).
p66SHC-mediated oxidative stress and telomere shortening synergize in some tissues (including testes) to accelerate aging.
Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (zeige POLD3 Proteine) activation involving Ser (zeige SIGLEC1 Proteine)(139) and a motif surrounding Ser (zeige SIGLEC1 Proteine)(213).
JNK1 (zeige MAPK8 Proteine)/2-dependent regulation of p66ShcS36 phosphorylation, is reported.
Data show that the major mitochondrial partner of Shc adaptor protein p46Shc is the lipid oxidation enzyme 3-ketoacylCoA thiolase (zeige HADHB Proteine) ACAA2 (zeige ACAA2 Proteine), to which p46Shc binds directly and with a strong affinity.
p53 (zeige TP53 Proteine)-dependent augmentation of p66(Shc) expression and function represents a key signalling response contributing to beta cell apoptosis under conditions of lipotoxicity
Silencing of p66(Shc) restored insulin (zeige INS Proteine) response via IRS-1 (zeige IRS1 Proteine)/Akt (zeige AKT1 Proteine)/eNOS (zeige NOS3 Proteine) pathway. Its knockdown in endothelial cells from Ob/Ob mice lessened ROS (zeige ROS1 Proteine) production, FFA oxidation, and dysregulation of redox-sensitive pathways.
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
SHC (Src homology 2 domain containing) transforming protein 1
, Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
, squalene--hopene cyclase
, SH2 domain protein C1
, SHC-transforming protein 1
, src homology 2 domain-containing-transforming protein C1
, SHC-transforming protein 1-like
, SHC (Src homology 2 domain-containing) transforming protein 1
, SHC-transforming protein 3
, SHC-transforming protein A
, src homology 2 domain-containing transforming protein C1
, src homology collagen
, adaptor protein SHC