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Human Polyclonal ROR2 Primary Antibody für FACS, IHC (p) - ABIN392044
Afzal, Rajab, Fenske, Oldridge, Elanko, Ternes-Pereira, Tüysüz, Murday, Patton, Wilkie, Jeffery: Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. in Nature genetics 2000
Show all 7 Pubmed References
Human Polyclonal ROR2 Primary Antibody für IHC (p), WB - ABIN392046
Oldridge, Fortuna, Maringa, Propping, Mansour, Pollitt, DeChiara, Kimble, Valenzuela, Yancopoulos, Wilkie: Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. in Nature genetics 2000
Show all 6 Pubmed References
ROR1 (zeige ROR1 Antikörper) and ROR2 play distinct roles in endometrial cancer. ROR1 (zeige ROR1 Antikörper) may promote tumor progression, while ROR2 may act as a tumor suppressor in endometrioid endometrial cancer.
Wnt5a (zeige WNT5A Antikörper)-Ror2 signaling enhanced tongue SCC (zeige CYP11A1 Antikörper) cell aggressiveness and promoted production of MMP-2 (zeige MMP2 Antikörper) following DeltaNp63beta-mediated EMT (zeige ITK Antikörper)
In squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder positive ROR2 or WNT5a (zeige WNT5A Antikörper) expression is generally associated with a poor prognosis.
Wnt5a (zeige WNT5A Antikörper) suppressed osteoblastic differentiation through Ror2/JNK (zeige MAPK8 Antikörper) signaling in periodontal ligament stem cell-like cells.
Data show that receptor tyrosine kinase-like orphan receptor 2 (ROR2) is epigenetically silenced by promoter hypermethylation in colorectal cancer cell lines and in early stages of colorectal neoplasia tissue.
WNT5A (zeige WNT5A Antikörper) and ROR2 are induced by inflammatory mediators through NF-kB and STAT3 (zeige STAT3 Antikörper) transcription factors, and are involved in the migration of human ovarian cancer cell line SKOV-3.
On these bases, we identified that miR (zeige MLXIP Antikörper)-208b targets receptor tyrosine kinase-like orphan receptor 2 gene by which miR (zeige MLXIP Antikörper)-208b can regulate the development of osteosarcoma.
Our findings suggest that receptor tyrosine kinase-like orphan receptor 2 may be an important regulator of epithelial-mesenchymal transition, primarily regulated the non-canonical Wnt (zeige WNT2 Antikörper) signaling pathway in ovarian cancer cells, and may display a promising therapeutic target for ovarian cancer.
Knockdown of Ror2 expression in renal cell carcinoma (zeige MOK Antikörper) cells significantly reduced cell proliferation and induced apoptosis.
found no association between ROR2 staining and poor patient survival
Ror2 plays a critical role in regulating the cell cycle progression of reactive astrocytes following brain injury
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2, which influenced Ras Homology Family Member A (zeige CXCL14 Antikörper) (RhoA (zeige RHOA Antikörper)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (zeige ROCK1 Antikörper)) activity downstream of Dishevelled-2 (Dvl2 (zeige DVL2 Antikörper)).
Here, the study of two Ror2 mutants connects aberrant germ cell migration to defects in meiosis and supports the diffusion model of meiotic entry.
Although Ror1 (zeige ROR1 Antikörper)-mutant mice show no apparent defects in ureteric bud (UB) formation, Ror1 (zeige ROR1 Antikörper); Ror2-double-mutant mice exhibit either defects in UB outgrowth and branching morphogenesis, associated with the loss of the MM from the UB domain, or ectopic formation of the UB.
The Wnt5a (zeige WNT5A Antikörper)-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma (zeige IFNG Antikörper) in colitis
Non-canonical Wnt5a (zeige WNT5A Antikörper)/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension.
Ror2 plays an important role in mammary gland development in mice.
The activation of Wnt5a (zeige WNT5A Antikörper)-Ror2 signaling in epithelial cells undergoing epithelial-to-mesenchymal transition (EMT (zeige ITK Antikörper)) may play an important role in disrupting TBM via MMP-2 (zeige MMP2 Antikörper) induction during renal fibrosis.
The results indicate an important role of Wnt5a (zeige WNT5A Antikörper)-Ror2 signaling in morphogenesis of the metanephric mesenchyme to ensure proper epithelial tubular formation of the ureteric bud required for kidney development.
This study provides a method to investigate the effects of the Wnt (zeige WNT2 Antikörper) pathway on the fate of mesenchymal stem cells (MSC (zeige MSC Antikörper)) in vivo and for the further improvement of MSC (zeige MSC Antikörper)-based therapies.
In the Xenopus embryo, Ptk7 (zeige PTK7 Antikörper) functionally interacts with Ror2 to regulate protocadherin papc (zeige PCDH8 Antikörper) expression and morphogenesis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2, which require Wnt5a (zeige WNT5A Antikörper)/Ror2 signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (zeige PCDH8 Antikörper) signaling via RhoA (zeige RHOA Antikörper) and Wnt5a (zeige WNT5A Antikörper)/Ror2 activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Transcriptional regulation of XPAPC (zeige PCDH8 Antikörper) by XWnt-5A (zeige WNT5A Antikörper) requires the receptor tyrosine kinase Ror2.
demonstrated that this anti-canonical Wnt (zeige WNT2 Antikörper) activity of Del1 is dependent on the Ror2 pathway, which is activated by the non-canonical Wnt (zeige WNT2 Antikörper) ligands
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
neurotrophic tyrosine kinase receptor-related 2
, tyrosine-protein kinase transmembrane receptor ROR2
, neurotrophic tyrosine kinase, receptor related 2
, neurotrophic tyrosine kinase, receptor-related 2
, receptor tyrosine kinase-like orphan receptor 2
, tyrosine-protein kinase transmembrane receptor ROR2-like
, LOW QUALITY PROTEIN: tyrosine-protein kinase transmembrane receptor ROR2
, receptor tyrosine kinase Xror2
, receptor tyrosine kinase like orphan receptor 2 L homeolog
, receptor tyrosine kinase-like orphan receptor 2 L homeolog