anti-RHOG (RHOG) Antikörper

Mouse (Murine) Ras Homolog Family Member G (RHOG) Interaktionspartner

1. ELMO2 (zeige ELMO2 Antikörper)-RhoG-ILK (zeige ILK Antikörper) complex has a key role in integrin-independent stabilization of the microtubule network in differentiated keratinocytes.

2. RhoG is expressed and activated in platelets, plays an important role in GPVI (zeige GP6 Antikörper)-Fc receptor gamma-chain (zeige FCER1G Antikörper) complex-mediated platelet activation, and is critical for thrombus formation in vivo.

3. RhoG protein regulates platelet granule secretion and thrombus formation in mice.

4. Examined the role of RhoG in the invasive behavior of glioblastoma cells; found that depletion of RhoG strongly inhibits activation of the Rac1 GTPase by both HGF and EGF; also RhoG contributes to the formation of lamellipodia and invadopodia.

5. several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac (zeige AKT1 Antikörper), CDC42 (zeige CDC42 Antikörper), and RhoG small GTPase (zeige RACGAP1 Antikörper) activities

6. Results indicate that RhoG promotes neural progenitor cell proliferation through PI3K in cortical development.

7. RhoG function is mediated by signals independent of Rac1 and Cdc42 (zeige CDC42 Antikörper) activation and instead by direct utilization of a subset of common effectors

8. different biological properties of RhoG and Rac1 can be traced to specific amino acid variations in their switch I, beta2/beta3 hairpin, alpha5 helix, and C-terminal polybasic regions.

9. In RhoG deficient mice, the development of B and T lymphocytes was unaffected. However, there was an increase in the level of serum IgG1 and IgG2b as well as a mild increase of the humoral immune response to thymus-dependent antigens.

10. define RhoG as a critical component of G protein-coupled receptor (zeige GPR34 Antikörper)-stimulated signaling cascades in murine neutrophils

Human Ras Homolog Family Member G (RHOG) Interaktionspartner

1. High RHOG expression is associated with lung adenocarcinoma.

2. RhoG and SGEF (zeige ARHGEF26 Antikörper) modulate the phosphorylation of paxillin (zeige PXN Antikörper), which plays a key role during invadopodia disassembly.

3. yrosine phosphorylation of SGEF (zeige ARHGEF26 Antikörper) suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF (zeige ARHGEF26 Antikörper)-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl (zeige MCF2 Antikörper) homology domain, as a major phosphorylation site of SGEF (zeige ARHGEF26 Antikörper) by Src (zeige SRC Antikörper), and Y530F mutation blocked the inhibitory effect of Src (zeige SRC Antikörper) on SGEF (zeige ARHGEF26 Antikörper)

4. These results suggest that the levels of RhoG and RhoB GTPases and their negative regulator RhoGDI3 might be linked to the aggressiveness of the pancreatic cancerous cell lines. It is possible that RhoGDI3 could induce the downregulation of RhoG and RhoB.

5. These data suggest a novel link between Tiam1 and RhoG/ILK /ELMO2 pathway as upstream effectors of the Rac1-mediated phagocytic process in trabecular meshwork cells.

6. This study describes the regulation of EMT (zeige ITK Antikörper) in RPE (zeige RPE Antikörper) cells by TGF-beta1 (zeige TGFB1 Antikörper)/miR (zeige MLXIP Antikörper)-124/RHOG signaling and suggests that the supplement of miR (zeige MLXIP Antikörper)-124 exogenously would be a valuable therapeutic approach for the prevention or treatment of proliferative vitreoretinopathy.

7. RhoG is expressed and activated in platelets, plays an important role in GPVI (zeige GP6 Antikörper)-Fc receptor gamma-chain (zeige FCER1G Antikörper) complex-mediated platelet activation, and is critical for thrombus formation in vivo.

8. several Rho family small GTPases activate PI3K (zeige PIK3CA Antikörper) by an indirect cooperative positive feedback that required a combination of Rac (zeige AKT1 Antikörper), CDC42 (zeige CDC42 Antikörper), and RhoG small GTPase (zeige RACGAP1 Antikörper) activities

9. The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.

10. The activation of RhoG recruits its effector ELMO2 (zeige ELMO2 Antikörper) and a Rac (zeige AKT1 Antikörper) GEF (zeige SLC2A4RG Antikörper) Dock4 (zeige DOCK4 Antikörper) to form a complex with EphA2 (zeige EPHA2 Antikörper) at the tips of cortactin (zeige CTTN Antikörper)-rich protrusions in migrating breast cancer cells.