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anti-Human PTK7 Antikörper:
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Human Polyclonal PTK7 Primary Antibody für IHC, ELISA - ABIN1003049
Park, Lee, Lee: Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. in Journal of biochemistry 1997
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Human Polyclonal PTK7 Primary Antibody für IHC, ELISA - ABIN1003048
Müller-Tidow, Schwäble, Steffen, Tidow, Brandt, Becker, Schulze-Bahr, Halfter, Vogt, Metzger, Schneider, Büchner, Brandts, Berdel, Serve: High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets. in Clinical cancer research : an official journal of the American Association for Cancer Research 2004
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Human Monoclonal PTK7 Primary Antibody für IHC, ELISA - ABIN969374
Shin, Maeng, Jung, Min, Kwon, Lee: Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis. in Biochemical and biophysical research communications 2008
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Human Polyclonal PTK7 Primary Antibody für IHC (p), WB - ABIN2476280
Easty, Mitchell, Patel, Flørenes, Spritz, Bennett: Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma. in International journal of cancer. Journal international du cancer 1997
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Human Polyclonal PTK7 Primary Antibody für FACS, IHC (p) - ABIN392230
Wang, Li, Yin, Wang, Wang, Wei, Guo, Ma, Shi, Zhou, Wang: PTK7 protein is decreased in epithelial ovarian carcinomas with poor prognosis. in International journal of clinical and experimental pathology 2014
PTK7 localization and protein stability is affected by canonical Wnt (zeige WNT2 Antikörper) ligands.
These findings demonstrate that PTK7 upregulates MMP9 (zeige MMP9 Antikörper) through activation of AP-1 (zeige FOSB Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) and, thus increases invasive properties of ESCC cells.
PTK7 overexpression is associated with esophageal squamous cell carcinoma.
Our data indicate that PTK7 protein expression is associated with the prognosis of oral tongue squamous cell carcinoma
PTK7 expression was correlated with tumor differentiation (P=0.027), lymph node metastasis (P=0.005), distant metastasis (P=0.001) and TNM (zeige ODZ1 Antikörper) stage (P=0.028) of colorectal cancer patients
High PTK7 expression is associated with radioresistance in esophageal squamous cell carcinoma.
PTK7 enriches in self-renewing, multipotent stem cells of the human colon.
findings implicate PTK7 as a risk factor for NTDs and provide additional evidence for a pathogenic role of PCP (zeige PRCP Antikörper) signaling in these malformations
overexpression in PTK7-negative cancer cells led to increased metastatic events. PTK7 expression thus represents a potential prognostic biomarker and a novel therapeutic target in CRC (zeige CALR Antikörper).
data demonstrates that PTK7 regulates the activity of KDR (zeige KDR Antikörper) biphasically by inducing oligomerization of KDR (zeige KDR Antikörper) molecules at lower concentrations and by surrounding KDR (zeige KDR Antikörper) molecules at higher concentrations.
In a Ptk7-deficient mouse strain, loss of Ptk7 leads to a diminished pool of hematopoietic stem cells but does not affect in vitro or in vivo differentiation. This is correlated with increased quiescence and reduced homing abilities of Ptk7-deficient hematopoietic stem and progenitor cells.
Data suggest that protein tyrosine kinase 7 (PTK7) is essential for Wolffian duct morphogenesis and male fertility.
PTK7 expression plays an important role in the invasiveness of intrahepatic cholangiocarcinoma cells.
Planar polarity of neural cell motility and intercalation requires Ptk7 function.
acts in conjunction with the noncanonical Wnt pathway to orient epithelial planar cell polarity through modulation of myosin II-based contractile tension between supporting cells and hair cells
The tyrosine kinase receptor (zeige KDR Antikörper), PTK7, is implicated in beta-catenin (zeige CTNNB1 Antikörper)-dependent developmental processes.
These findings illustrate a novel and pivotal role for Cdx (zeige CDX1 Antikörper) function upstream of Ptk7 and neural tube closure in vertebrates.
Chuzhoi mutation, that causes multiple abnormalities maps, to Chromosome 17 and carries a splice site mutation in Ptk7 and causes disruption of Ptk7 protein expression.
Ptk7 mRNA was expressed at high levels in lung and un-pregnant uterus among adult tissues, and in the tail, limbs, somites, gut (zeige GUSB Antikörper), and craniofacial regions among embryonic tissues, and suggest that PTK7 plays multiple roles in embryonic development.
This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PTK7 protein tyrosine kinase 7
, inactive tyrosine-protein kinase 7
, tyrosine-protein kinase-like 7-like
, colon carcinoma kinase 4
, pseudo tyrosine kinase receptor 7
, tyrosine-protein kinase-like 7
, serum response factor
, protein chuzhoi
, protein-tyrosine kinase 7
, receptor tyrosine kinase-like protein
, kinase-like protein