Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
PDGFRA is not essential for the derivation and maintenance of extraembryonic endoderm stem (XEN) cell lines .
loss of Pdgfra in endothelial-derived (zeige MED28 Proteine) mesenchyme in the outflow tract endocardial cushions leads to a secondary defect in neural crest migration during development.
Investigated the developmental process of mesenchymal stem cells (MSCs) in embryos using the gene Pdgfra as a marker. We traced cells expressing Pdgfra and other genes (brachyury (zeige TBX1 Proteine), Sox1 (zeige SOX1 Proteine) and Pmx1 (zeige PRRX1 Proteine)) in various mutant embryos until the adult stage. Embryonic MSCs emerge in waves and almost all adult bone marrow MSCs and white adipose tissue MSCs originate from mesoderm and embryonic Pdgfralpha-positive cells.
PDGFRalpha/PDGFRbeta signaling balance determines progenitor commitment to beige (PDGFRalpha) or white (PDGFRbeta) adipogenesis.
Spreading of PDGFR-alpha-deficient lung fibroblasts was insensitive to increased rigidity, and their migration was not reduced by Rac1-guanine exchange factor (GEF (zeige ARHGEF2 Proteine))-inhibition. PDGFR-alpha-expressing fibroblasts migrated toward stiffer regions within two-dimensional substrates by increasing migrational persistence (durotaxis).
Histone H3.3K27M and Trp53 (zeige TP53 Proteine) loss and PDGFRA overexpression accelerates disease onset and increases tumor invasion.
The diabetes-induced increase in PDGFRalpha+ cells may be mediated by FOXO3 up-regulation via the inhibition of the PI3K/Akt signaling pathway in STZ-induced diabetic mice.
Constitutive activation of PDGFRalpha leads to expansion of cartilage underlying the coronal sutures, which contribute to suture closure through endochondral ossification, in a process regulated in part by PI3K/AKT (zeige AKT1 Proteine) signaling.
OLIG2 (zeige OLIG2 Proteine) modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) or platelet-derived growth factor receptor alpha.
Conditional knockout of Pdgfra in Pdgfra-expressing tissues in mouse embryos at different embryonic days (E9.5 and E10.5) resulted in multiple developmental anomalies of the frontonasal region, the cranium and the abdominal wall musculature. Furthermore, the day at which the Pdgfra is deleted influences the repertoire of the anomalies of the conditional knockout embryos.
High PDGFR (zeige PDGFRB Proteine) expression is associated with retinal neovascularization.
None of the 16 analyzable tumors showed mutations in PDGFRA. Thus, PDGFRA mutations probably do not play an important role in the development of sporadic lipomas of the intestines
Whole transcriptome sequencing followed by pathway analysis indicated that STXBP4 (zeige STXBP4 Proteine) is involved in functional gene networks that regulate cell growth, proliferation, cell death, and survival in cancer. Platelet-derived growth factor receptor alpha (PDGFRalpha) was a key downstream mediator of STXBP4 (zeige STXBP4 Proteine) function. In line with this, shRNA mediated STXBP4 (zeige STXBP4 Proteine) and PDGFRA knockdown suppressed tumor growth in soft-agar and xenograft ...
We report a unique case of an SDH (zeige SARDH Proteine)-deficient GIST case with an activating PDGFRA mutation. Oncogenic mutations in GIST are generally mutually exclusive; however documented exceptions exist which may have diagnostic and therapeutic implications.
Case Report: concurrent development of myeloproliferative hypereosinophilic syndrome and lymphomatoid papulosis associated with FIP1L1 (zeige FIP1L1 Proteine)-PDGFRA gene fusion.
Our results suggest that PDGFRalpha overexpression in HCC (zeige FAM126A Proteine) is a prognostic marker independent of adjacent non-tumor site liver fibrosis status.
overview of primary cilia-mediated regulation of receptor tyrosine kinase (zeige RET Proteine) (RTK- PDGFRa and PDGFRb (zeige PDGFRB Proteine)) and transforming growth factor beta (TGF-beta) signaling [review]
PDGFRA mutation, but not amplification is associated with older age in pediatric high-grade glioma.
Study demonstrates for the first time that PDGFR-alpha strongly inhibits endothelial and melanoma cells proliferation in a CXCL10/IP-10 (zeige CXCL10 Proteine) dependent way, via miR (zeige MLXIP Proteine)-503 down-regulation.
PDGFRalpha activation is an essential component that drives aggressiveness in papillary thyroid carcinoma cells. The signaling pathways are complex, involving not only the MAPK/Erk (zeige MAPK1 Proteine) but also the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) and STAT3 (zeige STAT3 Proteine) pathways.
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
platelet-derived growth factor receptor, alpha polypeptide
, alpha-type platelet-derived growth factor receptor-like
, Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)
, CD140 antigen-like family member A
, PDGF alpha chain
, alpha-type platelet-derived growth factor receptor
, platelet-derived growth factor alpha receptor
, platelet-derived growth factor receptor alpha
, alpha platelet-derived growth factor receptor
, CD140a antigen
, PDGFRA/BCR fusion
, platelet-derived growth factor receptor 2
, rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
, tyrosine kinase PDGFR