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Investigated the developmental process of mesenchymal stem cells (MSCs) in embryos using the gene Pdgfra as a marker. We traced cells expressing Pdgfra and other genes (brachyury (zeige TBX1 Proteine), Sox1 (zeige SOX1 Proteine) and Pmx1 (zeige PRRX1 Proteine)) in various mutant embryos until the adult stage. Embryonic MSCs emerge in waves and almost all adult bone marrow MSCs and white adipose tissue MSCs originate from mesoderm and embryonic Pdgfralpha-positive cells.
PDGFRalpha/PDGFRbeta signaling balance determines progenitor commitment to beige (PDGFRalpha) or white (PDGFRbeta) adipogenesis.
Spreading of PDGFR-alpha-deficient lung fibroblasts was insensitive to increased rigidity, and their migration was not reduced by Rac1-guanine exchange factor (GEF (zeige ARHGEF2 Proteine))-inhibition. PDGFR-alpha-expressing fibroblasts migrated toward stiffer regions within two-dimensional substrates by increasing migrational persistence (durotaxis).
Histone H3.3K27M and Trp53 (zeige TP53 Proteine) loss and PDGFRA overexpression accelerates disease onset and increases tumor invasion.
The diabetes-induced increase in PDGFRalpha+ cells may be mediated by FOXO3 up-regulation via the inhibition of the PI3K/Akt signaling pathway in STZ-induced diabetic mice.
Constitutive activation of PDGFRalpha leads to expansion of cartilage underlying the coronal sutures, which contribute to suture closure through endochondral ossification, in a process regulated in part by PI3K/AKT (zeige AKT1 Proteine) signaling.
OLIG2 (zeige OLIG2 Proteine) modulates growth factor signaling in two distinct populations of glioma stem cells, characterized by expression of either the epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) or platelet-derived growth factor receptor alpha.
Conditional knockout of Pdgfra in Pdgfra-expressing tissues in mouse embryos at different embryonic days (E9.5 and E10.5) resulted in multiple developmental anomalies of the frontonasal region, the cranium and the abdominal wall musculature. Furthermore, the day at which the Pdgfra is deleted influences the repertoire of the anomalies of the conditional knockout embryos.
FOXA3 (zeige FOXA3 Proteine) is a marker of the Sertoli cell lineage and of the adult Leydig cell population, and is a regulator of Pdgfra transcription in Leydig cells.
PDGFRalpha and PDGFRbeta are coexpressed in the craniofacial mesenchyme of mid-gestation mouse embryos and that ablation of Pdgfrb (zeige PDGFRB Proteine) in the neural crest lineage results in increased nasal septum width, delayed palatal shelf development, and subepidermal blebbing.
Our results suggest that PDGFRalpha overexpression in HCC (zeige FAM126A Proteine) is a prognostic marker independent of adjacent non-tumor site liver fibrosis status.
overview of primary cilia-mediated regulation of receptor tyrosine kinase (zeige RET Proteine) (RTK- PDGFRa and PDGFRb (zeige PDGFRB Proteine)) and transforming growth factor beta (TGF-beta) signaling [review]
PDGFRA mutation, but not amplification is associated with older age in pediatric high-grade glioma.
Study demonstrates for the first time that PDGFR-alpha strongly inhibits endothelial and melanoma cells proliferation in a CXCL10/IP-10 (zeige CXCL10 Proteine) dependent way, via miR (zeige MLXIP Proteine)-503 down-regulation.
PDGFRalpha activation is an essential component that drives aggressiveness in papillary thyroid carcinoma cells. The signaling pathways are complex, involving not only the MAPK/Erk (zeige MAPK1 Proteine) but also the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) and STAT3 (zeige STAT3 Proteine) pathways.
Perivascular PDGFR-alpha and -beta were identified as independent markers predicting survival in metastatic colorectal cancer (mCRC).
Data suggest that the platelet derived growth factor receptor alpha (PDGFRalpha)/Stat3 (zeige STAT3 Proteine) transcription factor/Rb1 (zeige RB1 Proteine) protein regulatory axis might represent a potential therapeutic target for glioblastoma (GBM) treatment.
Point mutations in the PDGFRa gene, which leads to amino acid residue changes activating the kinase of the receptor, occur in about 5% of Gastrointestinal Stroma Tumors. An activating deletion mutation of the PDGFRA gene has been described in a human Glioblastoma.
FIP1L1 (zeige FIP1L1 Proteine)/ PDGFRA associated chronic eosinophilic leukemia has an excellent long-term prognosis following imatinib therapy.
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
platelet-derived growth factor receptor, alpha polypeptide
, alpha-type platelet-derived growth factor receptor-like
, Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)
, CD140 antigen-like family member A
, PDGF alpha chain
, alpha-type platelet-derived growth factor receptor
, platelet-derived growth factor alpha receptor
, platelet-derived growth factor receptor alpha
, alpha platelet-derived growth factor receptor
, CD140a antigen
, PDGFRA/BCR fusion
, platelet-derived growth factor receptor 2
, rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
, tyrosine kinase PDGFR