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Bat Polyclonal PAK4 Primary Antibody für WB - ABIN610860
Jones, Jakubowicz, Pitossi, Maurer, Hemmings: Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. in Proceedings of the National Academy of Sciences of the United States of America 1991
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Human Polyclonal PAK4 Primary Antibody für IHC, ELISA - ABIN1002957
Jaffer, Chernoff: p21-activated kinases: three more join the Pak. in The international journal of biochemistry & cell biology 2002
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Human Polyclonal PAK4 Primary Antibody für ELISA, IF - ABIN4343475
Liu, Yang, Liu, Liu, Zhang, Xu, Zhu, Xu: p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma. in Urologic oncology 2015
Human Polyclonal PAK4 Primary Antibody für WB - ABIN4343476
Cianciola, Chung, Manor, Carlin: Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum. in Journal of virology 2017
Methylation at cg14010619 may modify PAK4 activity, which has been implicated in cisplatin resistance in malignant cell lines
PAK4 downregulated the level of p21 (zeige CDKN1A Antikörper) and enhanced the activity of Akt (zeige AKT1 Antikörper) as well. And we conclude that PAK4 acts as a regulator of cell cycle (zeige C13orf15 Antikörper) progression of vascular smooth muscle cells by mediating Akt (zeige AKT1 Antikörper) signaling and controlling p21 (zeige CDKN1A Antikörper) levels, which further modulate intimal hyperplasia and vascular smooth muscle cells proliferation
Findings revealed a novel function of PAK4 in thyroid stimulating hormone-induced papillary thyroid cancer progression.
The present study demonstrates that miR (zeige MLXIP Antikörper)-145 plays an important role in inhibiting cell migration by directly targeting PAK4, and identifies miR (zeige MLXIP Antikörper)-145-PAK4-LIMK1 (zeige LIMK1 Antikörper)-cofilin (zeige CFL1 Antikörper) as a novel regulatory pathway that contributed to colorectal cancer metastasis.
These findings revealed a novel glucose metabolism-related mechanism of PAK4 in promoting colon cancer cell growth, suggesting that PAK4 and/or G6PD (zeige G6PD Antikörper) blockage might be a potential therapeutic strategy for colon cancer.
PAK4 (but not PAK1 (zeige PAK1 Antikörper)) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF (zeige ARHGEF11 Antikörper).
these results indicate that PAK4 confers CDDP resistance via the activation of MEK (zeige MAP2K1 Antikörper)/ERK (zeige EPHB2 Antikörper) and PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) pathways. PAK4 and PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) pathways can reciprocally activate each other.
PAK4 activity was markedly decreased in postmortem brain tissue from Parkinson's disease (PD) patients and in rodent models of PD. Expression of constitutively active PAK4(S445N/S474E) (caPAK4) protected DA neurons in both the 6-hydroxydopamine and alpha-synuclein rat models of PD and preserved motor function.
Our results indicate that PAK4 plays an important role in the potentiation of insulin (zeige INS Antikörper) secretion by fatty acids downstream of GPR40 (zeige FFAR1 Antikörper).
PAK4 downregulation decreased PPARgamma (zeige PPARG Antikörper)-mediated Nox1 (zeige NOX1 Antikörper) expression and suppressed EMT (zeige ITK Antikörper) in IR-treated glioma cells.
PAK4 crystal structures can be classified into specific conformational groups, and that these groups are associated with previously unobserved hinging motions and an unusual conformation for the kinase hydrophobic core. Our findings therefore indicate that there may be a diversity of kinase hinging motions, and that these may indicate different mechanisms of regulation.
PAK4 microparticles may have a role in the ventilation-induced lung injury process
These data demonstrate the relevance of PAK4 in osteoclast differentiation and the potential of PAK4 inhibitors for treating osteoclast-related disorders.
PAK4 promotes alpha-MSH/UVB-induced melanogenesis via the CREB (zeige CREB1 Antikörper) and Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathways and suggest that PAK4 may be a potential therapeutic target in pigmentation disorders.
PAK4 phosphorylates Par6B (zeige PARD6B Antikörper) at Ser143 blocking its interaction with Cdc42 (zeige CDC42 Antikörper).
Defined here is the overlap in phosphopeptides regulated by K-Ras (zeige HRAS Antikörper), Cdc42 (zeige CDC42 Antikörper), and PAK4; perturbation of these signaling components affects phosphoproteins associated with microtubule depolymerization, cytoskeletal organization, and the cell cycle.
These results indicate that PAK4 functions, including control of actin dynamics, are necessary for normal development of the heart
p21-activated kinase 4 regulates regulatory myosin light chain phosphorylation and myosin contractility during FcgammaR-mediated phagocytosis.
the transient increase in PAK4 levels at early G1 reduces p21 (zeige D4S234E Antikörper) levels, thereby abrogating the activity of CDK4 (zeige CDK4 Antikörper)/CDK6 (zeige CDK6 Antikörper) kinases, and allowing cells to proceed with the cell cycle in a precisely coordinated way
Conditional Pak4 knockout mice were born normally, but displayed growth retardation and died prematurely. The brains showed a dramatic decrease in proliferation of cortical and striatal neuronal progenitor cells.
pak4 is dispensable in zebrafish.
Zebrafish pak4 is required for primitive myeloid cell development.
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, p21(CDKN1A)-activated kinase 4
, p21-activated kinase 4
, protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
, serine/threonine-protein kinase PAK 4
, p21 (CDKN1A)-activated kinase 4
, p21 protein (Cdc42/Rac)-activated kinase 4