Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
Human MERTK ELISA Kit für Sandwich ELISA - ABIN2703325
Qin, Wang, Ma, Yang, Fu, Liang, Huang, Yang, Zhong: The association of Tyro3/Axl/Mer signaling with inflammatory response, disease activity in patients with primary Sjögren's syndrome. in Joint, bone, spine : revue du rhumatisme 2015
Show all 2 Pubmed References
these data suggest that endogenous GAS6 (zeige GAS6 ELISA Kits) and Mer receptor signaling contribute to the establishment of prostate cancer stem cells in the bone marrow microenvironment
Sequence analysis revealed that the proband was a compound heterozygote with two independent mutations in MERTK, a novel nonsense mutation (c.2179C > T) and a previously reported missense variant (c.2530C > T). The proband's affected brother also had both mutations
this study shows that viral infection sensitizes fetal membranes by MERTK Inhibition
Knockdown of MERTK by shRNA in prostate cancer cells induced a decreased ratio of P-Erk1/2 to P-p38, increased expression of p27, NR2F1, SOX2, and NANOG, induced higher levels of histone H3K9me3 and H3K27me3, and induced a G1/G0 arrest, all of which are associated with dormancy.
MERTK G > A variant affects liver disease, nutrient oxidation and glucose metabolism in NAFLD (zeige TSC2 ELISA Kits).
Monocyte-induced MerTK cleavage on proreparative MHCII(LO) cardiac macrophages is a novel contributor to myocardial ischemic reperfusion injury.
Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 (zeige TYRO3 ELISA Kits) and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 (zeige TYRO3 ELISA Kits) and Mer expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 (zeige TYRO3 ELISA Kits) and Mer mRNA and increased shedding of sTyro3 and sMer.
evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (zeige TXK ELISA Kits) (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.
Small molecule and antibody inhibitors of AXL (zeige AXL ELISA Kits) and MER have recently been described, and some of these have already entered clinical trials. The optimal design of treatment strategies to maximize the clinical benefit of these AXL (zeige AXL ELISA Kits) and MER targeting agents are discussed in relation to the different cancer types and the types of resistance encountered.
A 48 bp insertion sequence was buried within the breakpoint; 18 bps shared homology to MIR4435-2HG and LINC00152, and 30 bp mapped to MERTK. The deletion cosegregated with arRP in the family.
evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (zeige TYRO3 ELISA Kits) (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.
these results suggest, for the first time, that MerTK is an intracellular negative feedback regulator that inhibits the inflammatory response of lipoteichoic acid -stimulated macrophages
the reciprocal activation of Axl (zeige AXL ELISA Kits) and Mer (zeige ERH ELISA Kits) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Reduced transcription of Mertk, rather than differences in MERTK protein structure, determines the reduced efficiency of apoptotic cell clearance in the Aath4a(DBA/DBA (zeige RPS19 ELISA Kits)) mice, which, in turn, contributes to their increased susceptibility to atherosclerosis.
Axl (zeige AXL ELISA Kits), Mertk and Tyro3 (zeige TYRO3 ELISA Kits) receptors are not required for Zika virus entry and infection.
Signaling through the Mer (zeige ERH ELISA Kits) proto-oncogene (zeige RAB1A ELISA Kits) tyrosine kinase (zeige TYRO3 ELISA Kits) (MerTK) receptor in cultured macrophages and in sterile inflammation in vivo promotes specialized proresolving mediator (SPM (zeige NPC1 ELISA Kits)) biosynthesis by a mechanism involving an increase in the cytoplasmic:nuclear ratio of a key SPM (zeige NPC1 ELISA Kits) biosynthetic enzyme, 5-lipoxygenase (zeige ALOX5 ELISA Kits).
These studies define the clearance of infected, apoptotic neutrophils by dendritic cells and Mer (zeige ERH ELISA Kits) receptor signaling as central to the early immune evasion strategies of L. major.
Tyro3 (zeige TYRO3 ELISA Kits) gene dosage modulates Mertk-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 (zeige TYRO3 ELISA Kits) in RPE phagocytosis, and suggest that an eQTL (zeige EQTN ELISA Kits) can modify a recessive Inherited photoreceptor degenerations.
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
, tyrosine-protein kinase Mer
, c-mer proto-oncogene tyrosine kinase
, MER receptor tyrosine kinase
, tyrosine-protein kinase Mer-like
, STK kinase
, proto-oncogene c-Mer
, receptor tyrosine kinase MerTK
, Tyro 12
, proto-oncogene tyrosine-protein kinase Mer
, Receptor tyrosine tinase gene probably the gene for Rdy
, proto-oncogene tyrosine-protein kinase MER
, retinal dystrophy