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Human KIT Ligand Protein expressed in Escherichia coli (E. coli) - ABIN2018375
Lili, Chaozhan, Xindu: Expression, renaturation and simultaneous purification of recombinant human stem cell factor in Escherichia coli. in Biotechnology letters 2006
Show all 4 Pubmed References
Mouse (Murine) KIT Ligand Protein expressed in Escherichia coli (E. coli) - ABIN413775
Fukuda, Bian, King, Pelus: The chemokine GRObeta mobilizes early hematopoietic stem cells characterized by enhanced homing and engraftment. in Blood 2007
Show all 2 Pubmed References
Human KIT Ligand Protein expressed in Escherichia coli (E. coli) - ABIN413772
Kinzfogl, Hangoc, Broxmeyer: Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. in Blood 2011
Mouse (Murine) KIT Ligand Protein expressed in Escherichia coli (E. coli) - ABIN804039
Vas, Wandhoff, Dörr, Niebel, Geiger: Contribution of an aged microenvironment to aging-associated myeloproliferative disease. in PLoS ONE 2012
SCF interferes with MRGPRX2 function at distinct levels, acting by acute interference with the MRGPRX2 initiated cascade, but also through restriction of receptor expression to perpetuate inhibition.
Together these findings indicate that SCF is a critical cytokine involved in the activation of Group 2 innate lymphoid cells that lead to more severe outcomes during chronic allergy and that the SCF248 isoform could be an important therapeutic target to control the disease progression.
Stem cell factor and NSC87877 combine to enhance c-Kit mediated proliferation of human megakaryoblastic cells
Microtubule hyperacetylation enhances KL1-dependent micronucleation under a Tau deficiency in mammary epithelial cells.
A genetic analysis revealed a novel heterozygous mutation c.645_650delTGTGTC which results in the in-frame deletion of Val216 and Ser217 in the extracellular domain of KIT in case of familial piebaldism. Mutant KIT was able to form a heterodimer with Wt KIT and bind SCF; however, the phosphorylation of KIT, STAT5 and ERK1/2 was markedly decreased.
Authors show here that cyclin F, a substrate receptor F-box protein for the SCF (Skp1/Cul1/F-box) family of E3 ubiquitin ligases, is a bona fide AKT substrate.
A statistically significant relationship was found between stem cell factor level and oocyte maturation, embryo quality, and clinical pregnancy.
PAR2 plays a direct role in melanogenesis by increasing SCF secretion from keratinocytes.
We did not find any KITLG mutation in two affected individuals with familial progressive hyperpigmentation and hypopigmentation.
results suggest that SCF can accelerate cell homing and the maturation of the pulp-dentin complex in human immature teeth.
SCF is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.
the critical physiological role of the KIT-ET3-NO pathway in fulfilling high demand (exceeding basal level) of endothelium-dependent NO generation for coping with atherosclerosis, pregnancy, and aging, is reported.
results revealed that the Th17-mediated inflammatory environment promotes mast cell accumulation through keratinocyte-derived SCF
Bone marrow adipocytes synthesize SCF, promoting hematopoietic stem cell proliferation/regeneration.
Hypoxia microenvironment in hepatocellular carcinoma up-regulates HIF2/SCF expression, which in turn promotes angiogenesis and HCC metastasis.
Insights into the transmembrane helix associations of Kit ligand have been reported.
There were no significant differences in CD334-SCF double-positive FB and CD31-SCF double-positive EC levels between the two periapical tissue groups (P > 0.05). CD14-SCF double-positive MP density was considerably higher in periapical granulomas than in cysts (P < 0.01).
A significant association of rs995030 of the KITLG gene with the development of testicular germ cell tumors (p = 0.029 for the allele G, p = 0.0124 for the genotype GG) was revealed.
Overexpression of SCF is associated with Lewis lung carcinoma.
both SCF and IL-31 play an important role in mediating inflammation and enhancing severity of atopic asthma.
our data establish Kitl as a critical regulator in the in vivoAGM and yolk sac endothelial niche
membrane-associated KitL and soluble c-Kit form a bi-directional signaling complex that acts in the developing thymus.
Study shows that endothelial cells (ECs)-derived stem cell factor (Scf) is exclusively produced by the arterial vasculature of the bone marrow and that selective Scf deletion in arterial ECs, but not sinusoidal ECs, alters bone marrow hematopoietic stem cell numbers.
The results of this study suggest that NAR relieves Lop-induced constipation by increasing the levels of interstitial cells of Cajal markers (c-Kit and SCF), as well as AQP3. Thus, NAR may be effective as a candidate in patients suffering from lifestyle-induced constipation.
persistent distention/stretch on colonic smooth muscle cells could suppress SCF production probably through Ca(2+) -ERK-AP-1-miR-34c deregulation.
Activation of c-kit signalling by SCF promotes migration of cardiac stem cells with increased phosphorylation of CXCR4-serine 339, p38 mitogen-activated protein kinase (p38 MAPK) and extracellular regulated protein kinases 1/2 (ERK1/2).
These findings support the view that SCF, in addition to its pro-proliferative effects, is important for the differentiation of MCs.
In vitro, SCF induced the phosphorylation of p38 MAPK and cofilin, leading to the migration of cardiac stem cells.
MAPK3/1 participates in primordial follicle activation through mTORC1-KITL signaling.
MicroRNA-205 maintains T cell development following stress by regulating Foxn1 and its two regulated targets, stem cell factor and ccl25, following stress.
These findings indicate the SCF/Kit signaling insufficiency may contribute to the underdevelopment of ICCs and intestinal motility dysfunction upon hypoxia exposure.
SCF/c-kit signaling may potentiate chronic hypoxia-induced vascular remodeling by modulating ERK activation. Inhibition of c-kit activity may be a potential strategy to alleviate PH
Kit ligand regulates the subcellular localization of FOXO3 in the neonatal mouse ovary.
The results of this study indicate that c-kit/KITL signalling also occurs in the human ovary, as established in various animal models, and may involve previously unknown autocrine signalling
Streptozotocin-induced diabetes was induced in cKit-mutant mice with low cKit expression in their endothelial cells.
study suggests extracellular HMGB1 participates in NLRP3 inflammasome activity and regulates IL-1beta associated sterile inflammation induced by MWCNT
SCF/c-kit signaling was required for TPA-induced migration and differentiation of hair follicle melanocytes.
These results show that mast cell deficiency, in the absence of Kit mutations, plays no role in the regulation of weight gain or insulin resistance.
expression in adipose tissues responsive to food availability and environmental temperature; expression altered in obese mice
Oocyte-derived signals interact locally to mediate granulosa and theca cell function. SCF has a role in modulating this local interaction.
Dietary supplementation with zinc oxide inhibits expression in the small intestine.
KIT-KL might not be associated with the growth initiation of porcine primordial oocytes, although they do enhance the survival of the oocytes
little evidence was found for the KITLG gene being linked to variation in colour
FGF7 may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG signaling pathway.
chi-miR-204-5p and chi-miR-211 could change the expression levels of the KITLG gene and reduce granulosa cell proliferation.
g.13090G>T and g.13664C>A SNPs significantly affected litter size; litter size of individuals with the combined genotype GG/CC from both dairy goat breeds was greater than that of individuals with TT/AA in average parity
Results suggest that the KITLG gene is a strong candidate gene affecting litter size in goats.
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene.
, c-Kit ligand
, familial progressive hyperpigmentation 2
, kit ligand
, mast cell growth factor
, steel factor
, stem cell factor
, C-kit ligand
, Steel factor
, cloud gray
, hematopoietic growth factor KL
, steel factor/kit ligand
, stem cell factor KL-1
, KIT ligand precursor form 1
, KIT ligand precursor form 4
, c-kit ligand
, stem cell factor, CSF
, mast cell growth factor (white heifer disease)
, Mast cell growth factor
, stem cell factor homolog